A5100341172- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Marine and coastal ecosystems
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Arctic and Antarctic ice dynamics
- Oceanographic and Atmospheric Processes
- Corneal surgery and disorders
- Uterine Myomas and Treatments
- Pregnancy and preeclampsia studies
- Corneal Surgery and Treatments
- Ocean Acidification Effects and Responses
- Endometriosis Research and Treatment
- Hemodynamic Monitoring and Therapy
- Methane Hydrates and Related Phenomena
- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Advanced MRI Techniques and Applications
- Gynecological conditions and treatments
- Ocular Surface and Contact Lens
- Enhanced Recovery After Surgery
- Ultrasound and Hyperthermia Applications
International Peace Maternity & Child Health Hospital
2021-2024
Shanghai Jiao Tong University
2021-2024
Brigham and Women's Hospital
2024
Harvard University
2024
Huaian First People’s Hospital
2024
Nanjing Medical University
2024
Xuzhou Medical College
2024
Second People’s Hospital of Huai’an
2024
Longgang Central Hospital
2024
Jinzhou Medical University
2009-2023
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA repertoire sequencing on paired synovial tissue blood samples from 12 seropositive RA patients. We identify clonally expanded CD4 + cells, including CCL5+ cells peripheral helper (Tph) which show a prominent transcriptomic signature of recent activation effector function. CD8 higher oligoclonality than with the largest clones enriched in GZMK+ possibly...
Abstract Background Implementation of high-risk human papillomavirus (hrHPV) screening has greatly reduced the incidence and mortality cervical cancer. However, a triage strategy that is effective, noninvasive, independent from subjective interpretation pathologists urgently required to decrease unnecessary colposcopy referrals in hrHPV-positive women. Methods A total 3251 women aged 30–82 years (median = 41 years) International Peace Maternity Child Health Hospital were included training...
•Ultrafast ultrasound imaging is a new method to evaluate arterial stiffness with PWV.•The lack of reference values PWV has precluded its widespread clinical use.•This study established based on Han Chinese population.•Age, BP, and BMI were the dominant determinants PWV. BackgroundUltrafast been demonstrated be an effective carotid through pulse-wave velocity (PWV) high reproducibility, but use in practice. The aims this establish for ultrafast prospective, multicenter, population-based...
Small cell lung cancer (SCLC) is one of the highly malignant tumors and a serious threat to human health. The aim present study was explore underlying molecular mechanisms SCLC. mRNA microarray datasets GSE6044 GSE11969 were downloaded from Gene Expression Omnibus database, differentially expressed genes (DEGs) between normal SCLC samples screened using GEO2R tool. Functional pathway enrichment analyses performed for common DEGs DAVID protein‑protein interaction (PPI) network constructed by...
The high morbidity, complex seasonality, and recurring risk of hand-foot-and-mouth disease (HFMD) exert a major burden in China. Forecasting its epidemic trends is greatly instrumental informing vaccine targeted interventions. This study sets out to investigate the usefulness an advanced exponential smoothing state space framework by combining Box-Cox transformations, Fourier representations with time-varying coefficients autoregressive moving average (ARMA) error correction (TBATS) method...
Nitrous oxide (N 2 O) is one of the most important greenhouse gases and contributes to depletion ozone in stratosphere. Estuaries are areas intensive biological production associated N O emissions through both denitrification nitrification processes. The spatial temporal variations Jiulong River Estuary, a subtropical estuary, were explored evaluate sources sinks this area. estuary was found be strong source O, its saturation surface water ranged from 113 2926% relative ambient atmospheric...
The infusion of large amounts Ringer’s lactate prolongs the functional gastrointestinal recovery time and increases number complications after open abdominal surgery. We performed an open-labelled clinical trial to determine whether hydroxyethyl starch or exerts these adverse effects when surgery is by laparoscopy. Eighty-eight patients scheduled for major cancer (83% laparoscopy) received a first-line fluid treatment with 9 ml/kg either 6% 130/0.4 (Voluven) lactate, just induction...
Abstract The nitrous oxide (N 2 O) distributions in a shelf‐slope‐basin section from the Chukchi Sea shelf to Abyssal Plain (CAP) western Arctic Ocean were observed for first time during fourth Chinese National Research Expedition (4th CHINARE) late August 2010. N O concentrations 11.4–16.9 nmol L −1 , corresponding saturation values of 92–118% surface water. In surface, biological factor was negligible production, and physical process dominated distribution. undersaturation may be result...
This study investigated the role of CpG island methylation CYP2E1 and CYP2D6 genes in liver injury induced by anti-TB drugs from an epigenetic perspective a Chinese cohort. A 1:1 matched nested case-control design was applied. Pulmonary tuberculosis (TB) patients, who underwent standard therapy developed were defined as cases, while those did not develop control. The two groups terms sex, treatment regimen, age. In 114 pairs levels plasma cell-free DNA found to be significantly correlated...
Many previous studies have found that transabdominal ultrasound may allow precise measurement of gastric emptying liquid meals. However, the clinical use this technique has been hampered by limitation might not accurately measure solid It is more important to solids instead liquids, as often delayed than liquids in motility disorders. Recently, after oral administration a cellulose-based contrast agents (TUS-OSCA) suggested be effective initial screening lesions. The aim study was explore...
To explore the potential value of ultrasound radiomics in differentiating between benign and malignant breast nodules by extracting radiomic features two-dimensional (2D) grayscale images establishing a logistic regression model.The clinical data 1000 female patients (500 pathologically patients, 500 patients) who underwent examinations at our hospital were retrospectively analyzed. The cases randomly divided into training validation sets ratio 7:3. Once region interest (ROI) lesion was...
Rationale and ObjectivesHigh-intensity focused ultrasound (HIFU) has been increasingly used for treatment of uterine leiomyoma. The superiority HIFU therapy targeting leiomyoma blood vessels, however, still needs to be further explored. This study aims evaluate the long-term efficacy fibroid devascularization with ultrasound-guided (USgHIFU) effects on ovarian reserve endometrial injury.Materials MethodsFibroid was assessed Adler grade obtained by color Doppler flow imaging power (PDI)....
The transcripts of the alpha1-proteinase inhibitor in cornea are different from those hepatocytes and monocytes, suggesting that gene transcription may respond to cell-specific regulatory mechanisms. Although information on structure has been obtained, little is known regarding cis- trans-acting factors regulate its expression. In this study, we cloned sequenced a 2. 7-kilobase 5'-flanking region upstream corneal initiation site gene, demonstrated functional promoter activity, identified...
Abstract The ocean, particularly the Southern Ocean, is considered a significant source of atmospheric N 2 O, which an ozone‐depleting greenhouse gas. However, there are limited data available supporting this conclusion. Thus, study sampled and analyzed oceanic O in Prydz Bay. results demonstrated that distribution embayment differed between north south sides Antarctic Slope Front (ASF), corresponding to different hydrographic characteristics on each side. Although air sea flux shelf break...
Elevations of plasma creatinine are common after major surgery, but their pathophysiology is poorly understood. To identify possible contributing mechanisms, we pooled data from eight prospective studies performed in four different countries to study circumstances during which elevation occurs. We included 642 patients undergoing mixed surgeries, mostly open gastrointestinal. Plasma and urinary a composite index for renal fluid conservation (Fluid Retention Index, FRI) were measured just...
We aimed to evaluate changes in ovarian reserve and quality of life women treated with ultrasound-guided high-intensity focused ultrasound (USgHIFU) for uterine fibroids. In this single-center prospective study, a total 69 patients fibroids USgHIFU from October 2018 November 2021 were enrolled. Fibroid volume, anti-Müllerian hormone (AMH) levels, fibroid symptom scores, symptoms (UFS-QOL) questionnaire scores before 1, 3, 6 months after treatment analyzed. Correlations between AMH levels...
Crystalloid fluid and vasoactive drugs are used in the early treatment of sepsis. The purpose present study was to examine how these alter plasma volume expansion, peripheral edema, urinary excretion.Twenty-five anesthetized sheep were made septic by cecal puncture a short infusion lipopolysaccharide. After 50 min, slow isotonic saline initiated: either contained no drug, norepinephrine (1 μg/kg/min), phenylephrine (3 dopamine (50 or esmolol μg/kg/min). Ten min later, 20 mL/kg Ringer´s...
Transabdominal ultrasound after oral administration of an echoic cellulose-based gastric contrast agent (TUS-OCCA) has recently been suggested as a valuable mass-screening tool for cancer. The aim this study was to propose producible stomach reporting and data system (Su-RADS) using TUS-OCCA cancer screening. includes information 2738 patients who underwent both gastroscopy examinations recorded in software system. Gastroscopy examination with pathological diagnosis considered gold standard....
Abstract Nitrous oxide in the surface water was measured using an automatic underway system, along with measurements of pCO 2 , dissolved oxygen, salinity, temperature, and sea ice coverage, a cruise track through Bering Sea Chukchi to Canadian Basin during 7 th Chinese National Arctic Research Expedition. The results show that, overall, regions are net sources N O atmosphere. Several oversaturation maxima were observed track, absolute maximum approximately 60%. According hydrographic...
This study aimed to establish the feasibility of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for devascularization uterine fibroids. Ultrasound color Doppler flow imaging (CDFI) and B-mode were used target fibroid vascularity. The vessels covered ablated by spots. In this study, 42 fibroids with a volume 66.98 ± 4.00 cm3 treated. No blood was detected post-treatment CDFI in 40 6-mo non-perfusion rate 75.23% 34.77% (n = 40). mean shrinkage 38.20% 43.89%, respectively, at 1 6...
To reduce the number of biopsies performed on benign breast lesions categorized as BI-RADS 4-5, we investigated diagnostic performance combined two-dimensional and three-dimensional shear wave elastography (2D + 3D SWE) with standard ultrasonography (US) for assessment lesions.