A5101739284- RNA Interference and Gene Delivery
- Plant Pathogens and Fungal Diseases
- Viral Infections and Immunology Research
- Plant Reproductive Biology
- Virus-based gene therapy research
- Plant Disease Resistance and Genetics
- Muscle Physiology and Disorders
- Tissue Engineering and Regenerative Medicine
- Advanced biosensing and bioanalysis techniques
- Mental Health Treatment and Access
- Signaling Pathways in Disease
- NF-κB Signaling Pathways
- Nanoparticle-Based Drug Delivery
- Nitric Oxide and Endothelin Effects
- Nanoplatforms for cancer theranostics
- Forest Insect Ecology and Management
- Polyamine Metabolism and Applications
- Immune Response and Inflammation
- Plant Pathogens and Resistance
- Pharmacy and Medical Practices
- Economic Zones and Regional Development
- Regional Economic and Spatial Analysis
- Chromosomal and Genetic Variations
- Bioinformatics and Genomic Networks
- Plant tissue culture and regeneration
Shanghai Jiao Tong University
2016-2023
Institute of Plant Protection
2019-2020
Ningbo University
2015
South Central Minzu University
2014
Temple College
2006
Texas A&M University
2006
Beijing Normal University
2006
University of Washington
2003
University of Iowa
2003
University of Missouri
2003
Background— More than 90% of Duchenne muscular dystrophy (DMD) patients develop cardiomyopathy, and many die cardiac failure. Despite tremendous progress in skeletal muscle gene therapy, few attempts have been made to treat cardiomyopathy. Microdystrophin genes are shown correct pathological lesions the mdx mouse model for DMD. Here, we tested therapeutic potential adeno-associated virus (AAV)–mediated microdystrophin therapy heart. Methods Results— AAV was delivered newborn cavity. The...
Abstract Heterogeneity and drug resistance of tumor cells are the leading causes incurability poor survival for patients with recurrent breast cancer. In order to accurately deliver biological anticancer drugs different subtypes malignant omnidirectional targeted treatment cancer, a distinct design is demonstrated by embedding liposome‐based nanocomplexes containing pro‐apoptotic peptide survivin siRNA (LPR) into Herceptin/hyaluronic acid cross‐linked nanohydrogels (Herceptin‐HA) fabricate...
Abstract Background Since proteins perform their functions by interacting with one another and other biomolecules, reconstructing a map of the protein-protein interactions cell, experimentally or computationally, is an important first step toward understanding cellular function machinery proteome. Solely derived from Gene Ontology (GO), we have defined effective method yeast protein interaction network measuring relative specificity similarity (RSS) between two GO terms. Description Based on...
Recent studies from our laboratory and others have shown that increases in cytoplasmic superoxide (O(2)(·-)) levels Akt activation play a key role agonist-stimulated NF-κB cardiomyocyte hypertrophy vitro. In this study, we tested the hypothesis adenovirus (Ad)-mediated intramyocardial gene transfer of dismutase (AdCu/ZnSOD) or dominant-negative form (AdDNAkt) mice would attenuate pressure overload-induced redox-sensitive transcription factor cardiac hypertrophy. Adult C57BL/6 were subjected...
A safe and efficient quaternary gene delivery system (named Q-complexes) was constructed based on self-assembly of molecules through noncovalent bonds. This formulated the cooperation competing interactions cationic liposomes, multifunctional peptides, DNA, followed by coating hyaluronic acid surface ternary complexes. The peptide composed two functional domains: penetrating hepatic tumor-targeted cell moiety (KRPTMRFRYTWNPMK) a wrapping sequence (polyarginine 16). effect spacer insertion...
Abstract Background As development of cardiac gene therapies progresses, virally mediated genetic manipulations in cultured cardiomyocytes has become an important experimental approach. While adenovirus (Ad)‐mediated transfer to neonatal and adult rat is well established, viral transduction mouse (AMCM) been more difficult. This study was designed test the hypothesis that culture medium a critical determinant efficient AMCM. Methods AMCM from 8‐week‐old C57BL/6 mice were either minimum...
The relationships between fixed asset investments, foreign trade and economic growth have become important issues on today's academia.This article aims at research the interaction growth, use Ningbo which is an port city of China for instance, trying to find out degree influence.Through using VAR model as tool empirical analysis, finally put forward policy recommendations benign development based three variables.
HomePlant DiseaseVol. 104, No. 3First Report of Leaf Spots and Necrosis Caused by Paraphaeosphaeria recurvifoliae on Yucca gloriosa in China PreviousNext DISEASE NOTES OPENOpen Access licenseFirst ChinaTianbo Ding, Zhenbo Li, Lei Guo, Jie LiTianbo DingKey Laboratory Integrated Crop Pest Management Shandong Province, College Plant Health Medicine, Qingdao Agricultural University, 266109, China, LiShandong Protection Station, Jinan, 250100, GuoKey Li†Corresponding author: Li; E-mail Address:...
Bioinformation showed that BnRabGDI3 gene promoter included a 2 064bp-long segment at the upstream translation start site in Brassica napus genome.Promoter sequence contained several anther specific cis-elements.To verify biology function,a recombinant vector was designated as pBnRabGDI3:GUS through replacement of CaMV35S pBI121 by cloned fragment.In vector,gus reporter driven promoter.GUS histochemical assay six independent transgenic plants gus expressed only anthers from 11th to 13th...
Studies have shown that arginase-I (Arg-I), an enzyme which utilizes L-arginine to form urea and ornithine for subsequent synthesis of polyamines, is up-regulated under various pathophysiological conditions such as tissue ischemia, cancer metastasis, wound healing inflammation, are known promote angiogenesis. However, the role Arg-I in angiogenesis remains unclear. Herein, we propose can To test this hypothesis, adenoviral vector encoding with GFP reporter gene (AdArg-IeGFP) was...