A5100385391- MicroRNA in disease regulation
- Antimicrobial Resistance in Staphylococcus
- Circular RNAs in diseases
- Bacterial biofilms and quorum sensing
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Extracellular vesicles in disease
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
- Neuroendocrine Tumor Research Advances
- Vascular Malformations and Hemangiomas
- Epigenetics and DNA Methylation
- Biochemical and Structural Characterization
- Cancer Genomics and Diagnostics
- Advanced Materials and Mechanics
- Peptidase Inhibition and Analysis
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Additive Manufacturing and 3D Printing Technologies
- Complex Network Analysis Techniques
- Immune cells in cancer
- Cancer-related gene regulation
- RNA modifications and cancer
Shanghai Jiao Tong University
2016-2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Shanghai Veterinary Research Institute
2023-2025
Chinese Academy of Agricultural Sciences
2023-2025
Hangzhou Women’s Hospital
2025
Renji Hospital
2014-2024
Huazhong University of Science and Technology
2022-2024
Tongji Hospital
2022-2024
Henan Academy of Agricultural Sciences
2024
Anhui Agricultural University
2024
// Shuli Liu 1, 2 , Dongxia Ye 1 Wenzheng Guo Wenwen Yu Yue He Jingzhou Hu Yanan Wang Ling Zhang Yueling Liao 2, 3 Hongyong Song Shuangshuang Zhong Dongliang Xu Huijing Yin Beibei Sun 4 Xiaofei Jingyi 5 Yadi Wu Binhua P. Zhou Zhiyuan Jiong Deng 3, Department of Oral and Maxillofacial–Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School Medicine, Shanghai, China Key Laboratory Cell Differentiation Apoptosis Chinese Minister Education, for Tumor Microenvironment...
Unlike advances in the genomics-driven precision treatment of cutaneous melanomas, current poor understanding molecular basis mucosal melanomas (MM) has hindered such progress for MM patients. Thus, we sought to characterize genomic landscape identify alterations with prognostic and/or therapeutic implications.Whole-genome sequencing (WGS) was performed on 65 samples, including 63 paired tumor blood samples and 2 matched lymph node metastases, a further droplet digital PCR-based validation...
Cerebral infarction ranks as the second leading cause of disability and death globally, inflammatory response glial cells is main brain damage during cerebral infarction.Studies have shown that mesenchymal stem (MSCs) can secrete exosomes contribute to disease. Here, we would explore function MSC-derived exosome in infarction.Microarray indicated a decrease miR-542-3p an increase Toll-Like Receptor 4 (TLR4) middle artery occlusion (MCAO) mice comparing with sham mice. And luciferase RIP...
Abstract Epithelial ovarian cancer (EOC) is a highly lethal gynecological malignancy, and cisplatin resistance usually correlated with the poor prognosis of EOC. Increasing evidence indicates that dysregulation miRNAs related to chemotherapy sensitivity. In this study, we revealed miR-98-5p, member let-7 family, was enriched in cisplatin-resistant EOC cells compared cisplatin-sensitive cells, could promote cells. Further studies showed miR-98-5p directly target 3′-UTR Dicer1 suppress its...
To identify the expression profile of novel microRNAs (miRNAs) in colon cancer and evaluate their clinical applicability.Differences serum miRNAs patients with healthy controls were identified using miRNA microarrays. Differentially expressed verified via real-time polymerase chain reaction (PCR) sera from 50 44 controls. These also a double-blind validation experiment 30 cancer, colonic polyps, controls.Microarray hybridization revealed that 87 differentially between Among these miRNAs, 39...
Abstract Dysregulation of circular RNA (circRNA) expression is involved in the progression cancer. Here, we aimed to study potential function hsa_circ_0006401 colorectal cancer (CRC). CircRNA levels CRC and adjacent nontumor tissues were analyzed by real-time quantitative PCR (qRT-PCR) circRNA situ hybridization (RNA-ISH). Then, cell proliferation was assessed counting. Wound-healing transwell assays utilized detect effect on migration. A circRNA-ORF construct created, a specific antibody...
Mechanical performance is crucial for lattice structures used in orthopedic applications because they should simultaneously possess high strength and porosity. Although the additively manufactured Ti-6Al-4 V functionally graded porous structure (FGPS) has proven to be most promising material owing its good mechanical performance, impact of porosity gradient pattern on their scarcely been investigated. In this study, FGPSs with varied same overall were designed by triply periodic minimal...
Background: Interleukin-1β (IL-1)-treated mesenchymal stem cells (MSCs) and IL-1-MSCs-conditioned medium (CM) exert anti-inflammatory roles. Astrocytes are essential for the modulation of synaptic activity neuronal homeostasis in brain. Exosomes critical mediators intercellular communication. However, mechanism underlying effect IL-1-treated MSCs remains unknown. Methods: In this study, exosomes (IL-1-Exo) were isolated from MSCs. addition, lipopolysaccharide (LPS)-treated hippocampal...
Induction chemotherapy in oral squamous cell carcinoma is a controversial issue clinical practice. To investigate the evolution of cancer cells and tumor microenvironment (TME) response to carcinoma, single-cell transcriptome analysis was performed post-chemotherapy located cavity. The main types were identified based on gene expression patterns determined using dimensionality reduction unsupervised clustering. Non-negative matrix factorization clustering Cancer-associated fibroblasts (CAFs)...
Staphylococcus aureus (SA) is a relatively uncommon cause of urinary tract infections (UTIs) in the general population. Although rare, S. aureus-induced UTIs are prone to potentially life-threatening invasive such as bacteremia. To investigate molecular epidemiology, phenotypic characteristics, and pathophysiology UTIs, we analyzed non-repetitive 4,405 isolates collected from various clinical sources 2008 2020 hospital Shanghai, China. Among these, 193 (4.38%) were cultivated midstream urine...
We assess the detectability of tidal disruption events (TDEs) using mock observations from Mini SiTian array. select 100 host galaxy samples a simulated catalog based on specific criteria such as redshift, BH mass, and event rate. Taking into account site conditions survey strategy, we simulate over 440 deg$^2$ field. The results indicate that $0.53\pm 0.73$ TDEs can be detected per year when observing in both $g$ $r$ bands with 300-second exposures every 3 days. Applying this method to...
ABSTRACT Endogenous nitric oxide (NO) is a small molecule that has been demonstrated to affect the physiology and survival of bacteria. The role endogenous NO for Staphylococcus aureus inside host cells remains unclear. Here, we show production by bacterial nitrate reductase (NR) affected molybdopterin biosynthesis protein A (MoeA), which essential molybdenum cofactor synthesis in S. . During infection, promotes macrophages initiating cellular autophagy. Mechanistically, can modify...
Objectives: To determine the correlation between decreased or increased retinol-binding protein (RBP) levels during pregnancy and adverse outcomes. Study Design: A retrospective cohort study was conducted to analyze data of 16,094 pregnant women who participated in serum RBP level detection pregnancy. The chi-square test Mann-Whitney U used for univariate analysis qualitative quantitative data. Multiple logistic regression analysis, odds ratio, 95% confidence interval were evaluate effect on...
B. microti is a tick-transmitted zoonotic erythrocytic intracellular parasite. Ferroptosis an iron-dependent form of programmed cell death that affects pathogen replication in the host. Currently, there limited research concerning effect tick ferroptosis on Babesia infection and underlying mechanism action. The present study used -mouse- Haemaphysalis longicornis model which nymphs fed blood -infected mice. midgut divalent iron ( p<0.01 ) reactive oxygen species (ROS) p<0.05...
Abstract Microglia are intrinsic immune cells in the central nervous system (CNS). The under controlled microglia activation plays important roles inflammatory demyelination diseases, such as multiple sclerosis (MS). However, means to modulate a therapeutic modality and underlying mechanisms remain elusive. Here we show that administration of 18β-glycyrrhetinic acid (GRA), by using both preventive treatment protocols, significantly suppresses disease severity experimental autoimmune...
// Shuli Liu 1, * , Dongxia Ye Dongliang Xu 2, 3 Yueling Liao Ling Zhang 1 Wenwen Yu Yanan Wang Yue He Jingzhou Hu Wenzheng Guo 2 Tong Beibei Sun 4 Hongyong Song Huijing Yin Jingyi 5 Yadi Wu Hanguang Zhu Binhua P. Zhou Jiong Deng 3, Zhiyuan Department of Oral and Maxillofacial–Head Neck Oncology, Ninth People’s Hospital, Shanghai Jiao University School Medicine, Shanghai, China Key Laboratory Cell Differentiation Apoptosis Chinese Minister Education, for Tumor Microenvironment...