A5100783649- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Planetary Science and Exploration
- Astro and Planetary Science
- Methane Hydrates and Related Phenomena
- Geology and Paleoclimatology Research
- Cancer Genomics and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- CRISPR and Genetic Engineering
- Acute Lymphoblastic Leukemia research
- Prostate Cancer Treatment and Research
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Chronic Kidney Disease and Diabetes
- Retinal Development and Disorders
- Image Processing and 3D Reconstruction
- bioluminescence and chemiluminescence research
- Natural Compounds in Disease Treatment
- Nanocluster Synthesis and Applications
- Colorectal Cancer Treatments and Studies
- Bioactive Compounds and Antitumor Agents
- Pancreatic function and diabetes
- Ferroptosis and cancer prognosis
- Safe Handling of Antineoplastic Drugs
- Microtubule and mitosis dynamics
Shanghai Jiao Tong University
2020-2025
Renji Hospital
2020-2024
Heilongjiang University of Chinese Medicine
2024
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2024
Zhengzhou University
2023
Changhai Hospital
2022
Second Military Medical University
2022
Ningbo University
2006-2021
Army Medical University
2015-2020
Southwest Hospital
2015-2020
Integration of the viral DNA into host chromosomes was found in most hepatitis B virus (HBV)-related hepatocellular carcinomas (HCCs). Here we devised a massive anchored parallel sequencing (MAPS) method using next-generation to isolate and sequence HBV integrants. Applying MAPS 40 pairs HBV-related HCC tissues (cancer adjacent tissues), identified 296 integration events corresponding 286 unique sites (UISs) with precise HBV-Human junctions. favored chromosome 17 preferentially integrated...
Pathological retinal angiogenesis resulting from a variety of ocular diseases including oxygen induced retinopathy, diabetic retinopathy and vein occlusion, is one the major reasons for vision loss, yet therapeutic option limited. Multiple nanoparticles have been reported to alleviate angiogenic retinopathy. However, adverse effect cannot be ignored due relatively large scale. Graphene quantum dots (GQDs) shown potential in drug delivery proved biocompatible. In this study, are extensively...
// Jiuxia Pang 1 , Na Shen Fei Yan Zhao Liping Dou 1, 2 Lai-Chu Wu 3 Christopher L. Seiler 4 Li Yu Ke Yang 5 Veronika Bachanova 6 Eric Weaver 7 Natalia Y. Tretyakova Shujun Liu The Hormel Institute, University of Minnesota, Austin, MN 55912, USA Department Hematology, Chinese PLA General Hospital, Medical School PLA, Beijing 100853, China Biological Chemistry and Pharmacology, Ohio State University, Columbus, OH 43021, Medicinal Chemistry, Minneapolis, 55455, Chongqing Engineering Research...
Staphylococcus aureus (S. aureus) is a clinical pathogen of great significance causing metastatic or complicated infections. ST5 clonotype isolates have dominated S. infections for more than 10 years in Shanghai, China, and the proportion methicillin-susceptible (MSSA) has remarkably increased past decades. By whole-genome sequencing (WGS) 121 using next-generation (NGS) platforms characterizing evolutionary dynamics linages, we found that MSSA evolved independently, making it subtype...
ABSTRACT Endogenous nitric oxide (NO) is a small molecule that has been demonstrated to affect the physiology and survival of bacteria. The role endogenous NO for Staphylococcus aureus inside host cells remains unclear. Here, we show production by bacterial nitrate reductase (NR) affected molybdopterin biosynthesis protein A (MoeA), which essential molybdenum cofactor synthesis in S. . During infection, promotes macrophages initiating cellular autophagy. Mechanistically, can modify...
Purpose: Receptor tyrosine kinases (RTKs) are frequently deregulated in leukemia, yet the biological consequences of this deregulation remain elusive. The mechanisms underlying aberrant methylation, a hallmark not fully understood. Here we investigated role RTKs methylation abnormalities and characterized hypomethylating activities RTK inhibitors.Experimental Design: Whether how regulate expression DNA methyltransferases (DNMTs), tumor suppressor genes (TSGs) as well global gene-specific...
Abstract Diverse post-translational modifications have been shown to play important roles in regulating protein function eukaryotes. By contrast, the of bacteria are not so well understood, particularly as they relate pathogenesis. Here, we demonstrate modification by covalent addition lactate lysine residues (lactylation) human pathogen Staphylococcus aureus . Lactylation is dependent on concentration and specifically affects alpha-toxin, which a single lactylated required for full activity...
Staphylococcus aureus is a high-virulent Gram-positive pathogen that responsible for serious of diseases. The emergence antibiotic-resistant S. poses significant challenge in terms treatment. recent research on the human microbiome suggested application commensal bacteria new strategy combating pathogenic infections. epidermidis, one most abundant species nasal microbiome, able to inhibit colonization aureus. However, during bacterial competition, undergoes evolutionary changes adapt diverse...
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Abstract High‐frequency lunar penetrating radar (LPR) data from an instrument on the rover Yutu, Chang'E‐3 (CE‐3) robotic lander, were used to build a three‐dimensional (3‐D) geological model of subsurface structure. The CE‐3 landing site is in northern Mare Imbrium. More than five significant reflection horizons are evident LPR profile, which we interpret as different period lava flow sequences deposited surface. most probable directions these flows inferred layer depths, thicknesses, and...
Abstract Objectives Fosfomycin resistance has become a clinical concern. In this study, we analysed the dynamic change of fosfomycin MIC in epidemic Staphylococcus aureus lineages teaching hospital Shanghai for 12 years and sought to elucidate major underlying mechanisms. Methods MLST was conducted 4580 S. isolates recovered from 2008 2019. determined by agar dilution method. The genome data 230 lineage were acquired next-generation sequencing (NGS) platform. Gene deletion corresponding...
The nasal carriage of Staphylococcus aureus introduces risks for subsequent infections, the rate which is particularly high in children. colonization mechanisms S. are not fully understood.The epidemiological characteristics colonizing strains from pediatric patients undergoing liver transplantation and healthy pre-school children were analyzed first. Phenotypes, including biofilm formation hemolytic activity, tested all isolates. Bacterial pathogenicity indicated by a mouse skin abscess...
To identify the disease-causing gene mutation in a Chinese pedigree with autosomal dominant cone-rod dystrophy (adCORD).A southern adCORD including 9 affected individuals was studied. Whole-exome sequencing (WES), coupling Agilent whole-exome capture system to Illumina HiSeq 2000 DNA platform used search specific 3 family members and 1 unaffected member. After suggested variant found through data analysis, putative validated by Sanger of samples from all available members.The results both...
The high degree of intra-tumor heterogeneity has meant that it is important to develop sensitive and selective assays detect low-abundance KRAS mutations in metastatic colorectal carcinoma (mCRC) patients. As a major potential source tumor DNA the aforementioned genotyping assays, was necessary conduct an analysis on both quality quantity extracted from formalin-fixed paraffin-embedded (FFPE). Therefore, four commercial FFPE extraction kits were initially compared with respect their ability...
Staphylococcus aureus is an important human commensal bacteria colonizing the body, especially nasal cavity. The carriage can be a source of S. bacteremia. However, bacterial factors contributing to colonization are not completely understood. By analysing strains from cavity children, young adults, and seniors, we found that low activity SaeRS two-component system (TCS) determinant for colonize in seniors. senior group isolates showed rather distinct sequence type composition as compared...
Prostate cancer (PCa) is a highly common among men but lacks robust diagnostics that can predict disease recurrence after initial treatment, for example, with radical prostatectomy. Recent advances in genomics and next-generation sequencing heralded the discovery of biomarkers such as androgen receptor gene (AR) splice events, TMPRSS2:EGR fusion, long noncoding RNA MALAT-1 SCHLAP1 PCa prognosis. Still, question why some patients experience recurrence, whereas others do not introduce marked...
Prostate cancer (PCa) is a common type of malignancy, which represents one the leading causes death among men worldwide. Copy number variations (CNVs) and gene fusions play important roles in PCa may serve as markers for prognosis this condition.We have presently conducted an analysis CNVs PCa, using whole exome sequencing (WES) data primary tumors. For this, cohort 74 patients, including 30 recurrent 44 non-recurrent cases, were assessed during 5 years follow-up.We identified 66 that...
Abstract Previous studies showed that the Eratosthenian mare (Em) unit in northern Mare Imbrium, which is location of Chang'e‐3 (CE3) landing site, was simply formed by one period thick lava flow. However, CE3 Yutu rover equipped with lunar penetrating radar (LPR) recognized multilayered Em basalts based on Channel 1 data reprocessed this paper, indicating three subdivided thin flows should exist. The spatial variation and thickness distribution each layer are further estimated interfaces...
Staphylococcus aureus is an important opportunistic pathogen which can localize in human nares and skin. The bacteria carriage was deemed as a risk factor because it cause endogenous S. infection. However, epidemiological characteristics of these colonized strains have not yet been identified. Here, we isolated analyzed all culturable from nasal skin swabs 526 healthy individuals with three different age groups. Obvious differences microbiomes either sites (the skin) or groups (children,...