A5004443237- Skin and Cellular Biology Research
- Plant Reproductive Biology
- Wnt/β-catenin signaling in development and cancer
- Mitochondrial Function and Pathology
- Cancer-related Molecular Pathways
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Retinal Development and Disorders
- Neuroendocrine Tumor Research Advances
- Polyamine Metabolism and Applications
- Chemical Synthesis and Analysis
- Histone Deacetylase Inhibitors Research
- PI3K/AKT/mTOR signaling in cancer
- Hedgehog Signaling Pathway Studies
- melanin and skin pigmentation
- Adrenal and Paraganglionic Tumors
- RNA modifications and cancer
- Bone health and treatments
- Gastrointestinal Tumor Research and Treatment
- NF-κB Signaling Pathways
- 2D Materials and Applications
Chongqing University of Posts and Telecommunications
2024-2025
University of Chinese Academy of Sciences
2024-2025
Affiliated Hospital of Jining Medical University
2019-2024
Kunming Institute of Zoology
2019-2023
Chinese Academy of Sciences
2019-2023
Zhejiang University
2012-2022
South China Agricultural University
2016-2021
Shandong Agricultural University
2016-2018
Second Affiliated Hospital of Zhejiang University
2016
Shaoxing People's Hospital
2016
Cellular senescence, characterized by stable cell cycle arrest, plays an important role in aging and age-associated pathologies. Eliminating senescent cells rejuvenates aged tissues ameliorates diseases. Here, we identified that natural killer group 2 member D ligands (NKG2DLs) are up-regulated vitro, regardless of stimuli induced cellular various mice nonhuman primates vivo. Accordingly, developed demonstrated chimeric antigen receptor (CAR) T targeting human NKG2DLs selectively effectively...
MicroRNA-34a (miR-34a) plays an essential role against tumorigenesis and progression of cancer metastasis. Here, we analyzed the expression, targets functional effects miR-34a on epithelial to mesenchymal transition-inducing transcription factors (EMT-TFs), such as TWIST1, SLUG ZEB1/2, EMT-inducing protein NOTCH1 in breast (BC) cell migration invasion its correlation with clinical outcomes. Expression is downregulated human metastatic cancers (MBC) compared normal tissues negatively...
Abstract Graphene, with exceptional carrier mobility and broad‐spectrum light absorption, provides a new platform for photodetection applications, thereby driving the development of next‐generation photodetectors. However, graphene photodetectors suffer from challenges such as low responsivity high noise. Due to its strong interaction density states, optoelectronic properties can be easily manipulated by local fields. Manipulation fields in is promising strategy improve detection performance...
Recent studies have suggested that the gut microbiota is altered in children with juvenile idiopathic arthritis (JIA). However, age, sex, and body mass index (BMI) were not matched previous studies, results are inconsistent. We conducted an age-, sex-, BMI-matched cross-sectional study to characterize JIA, evaluate its potential clinical prediction. A total of 40 patients JIA 42 healthy controls, ranging from 1 16 years, enrolled this study. Fecal samples collected for 16S rDNA sequencing....
Abstract Gastrointestinal stromal tumors (GISTs) are common neoplasms of the gastrointestinal tract that can be treated successfully using C-kit target therapy and surgery; however, imatinib chemoresistance is a major barrier to success in therapy. The present study aimed discover alternative pathways imatinib-resistant GISTs. Long noncoding RNAs (lncRNAs) newly discovered regulators chemoresistance. Previously, we showed lncRNA HOTAIR was upregulated recurrent In this study, analyzed...
Epithelial-mesenchymal transition (EMT) has been believed to be related with chemotherapy resistance in non-small cell lung cancer (NSCLC). Recent studies have suggested eIF5A-2 may function as a proliferation-related oncogene tumorigenic processes.We used viability assays, western blotting, immunofluorescence, transwell-matrigel invasion assay, wound-healing assay combined GC7 (a novel inhibitor) treatment or siRNA interference investigate the role of playing NSCLC chemotherapy.We found low...
Dirac semimetals have demonstrated significant attraction in the field of optoelectronics due to their unique bandgap structure and high carrier mobility. Combining them with classical semiconductor materials form heterojunctions enables broadband optoelectronic conversion at room temperature. However, low light absorption layered substantially limits device's responsivity infrared band. Herein, a three-dimensional (3D) heterostructure, composed silicon nanopillars (SiNPs) conformal PtTe
Background Whole exome sequencing provides a labor-saving and direct means of genetic diagnosis hereditary disorders in which the pathogenic gene harbors large cohort exons. We set out to demonstrate suitable example MEN 2A/FMTC (multiple endocrine neoplasia type 2/familial medullary thyroid carcinoma) using this approach. Methodology/Principal Findings sequenced whole six individuals from Chinese MEN2A/FMTC pedigree identify variants RET (REarranged during Transfection) protooncogene...
The importance of biogenic silver/silver chloride nanoparticles has become increasing day by day. In the present study, (Ag/AgCl-NPs) were synthesized from Kaempferia rotunda tuberous rhizome extract to evaluate antiproliferative activity against human glioblastoma stem cells (GSCs) in vitro and Ehrlich ascites carcinoma (EAC) vivo mice. Synthesis was confirmed colour change UV-visible spectrum characterized TEM, XRD, TGA, AFM FTIR. K recently Zizyphus mauritiana fruit extract-mediated...
Eukaryotic translation initiation factor 5A2 (eIF5A2) has been identified as a critical gene in tumor metastasis. Research suggested that reactive oxygen species (ROS) serve signaling molecules cancer cell proliferation and migration. However, the mechanisms linking eIF5A2 ROS are not fully understood. Here, we investigated effects of on eIF5A2-induced epithelial-mesenchymal transition (EMT) migration six hepatocellular carcinoma (HCC) lines. Western hybridization, siRNA transfection,...
Approximately 30% of breast cancer does not express the estrogen receptor (ER), which is necessary for endocrine-based therapy approaches. Many studies demonstrated that eukaryotic translation initiation factor 5A2 (eIF5A2) serves as a proliferation-related oncogene in tumorigenic processes. The present study used cell viability assays, EdU incorporation western blot, and immunofluorescence to explore whether N1-guanyl-1,7-diaminoheptane (GC7), inhibits eIF5A2 activation, exerts synergistic...
Abstract High mobility group box 1 (HMGB1) is a non-histone nuclear protein which has been intensively studied in various physiological and pathological processes including leukemia. Here this study, we further demonstrated that HMGB1 presents higher expression the bone marrow mononuclear cells of acute myeloid leukemia (AML) patients compared with normal controls contributes to AML pathogenesis progression by inhibiting apoptosis, facilitating proliferation, inducing differentiation...
Genetic screening for germline mutations in the RET proto-oncogene has been extensively exploited worldwide to optimize diagnostic and clinical management of multiple endocrine neoplasia type 2 (MEN2) patients their relatives. However, a distinct lag period exists not only recognition but also medical treatment with MEN2. Here we present comprehensive genetic analysis MEN2 among Chinese families followed from 1975 2011. Our series comprises 36 index cases 134 relatives 11 independent...
CRISPR/Cas9 has been confirmed as a distinctly efficient, simple-to-configure, highly specific genome-editing tool that used to treat monogenetic disorders. Epidermolytic palmoplantar keratoderma (EPPK) is common autosomal dominant keratin disease resulting from dominant-negative mutation of the KRT9 gene, and it no effective therapy. We performed CRISPR/Cas9-mediated treatment on knockin (KI) transgenic mouse model carried small indel heterozygous Krt9, c.434delAinsGGCT...
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by abnormal cell proliferation, apoptosis repression and differentiation blockade of hematopoietic stem/progenitor cells. Developing identifying novel therapeutic agents to reverse the pathological processes AML are great significance. Here in this study, we found that fungus-derived histone deacetylase inhibitor, Apicidin, presents promising effect on inhibiting facilitating inducing Mechanistic...
Increased propensity of bone marrow-derived mesenchymal stem cells (BM-MSCs) toward adipogenic differentiation has been implicated in the fatty marrow and defective hematopoiesis aplastic anemia (AA). However, underlying molecular mechanism remains to be investigated. In this study, we found that microRNA 199a-5p (miR-199a-5p) exhibits significantly higher expression AA BM-MSCs compared with normal control is demonstrated facilitate through lentivirus-mediated miR-199a overexpression....
Resistance to chemotherapeutic drugs is a major obstacle in non-small cell lung cancer (NSCLC) therapy. The molecular determinants of NSCLC resistance doxorubicin are unknown. In the present study, we investigated whether topoisomerase IIβ binding protein 1 (TopBP1) was involved chemoresistance cancer. We found that p53-deficient cells (NCI-H1299) displayed greatest compared with NCI-H358, A549, and HCC827 p53 expression. expression TopBP1 significantly higher NCI-H1299 than other three...
Increased propensity of bone marrow-derived mesenchymal stem cells (BM-MSCs) toward adipogenic differentiation at the expense osteogenesis has been implicated in obesity, diabetes, and age-related osteoporosis as well various hematopoietic disorders. Defining small molecules with role rectifying adipo-osteogenic imbalance is great significance. Here, we unexpectedly found that Chidamide, a selective histone deacetylases inhibitor, exhibited remarkably suppressive effect on vitro induced...
Knuckle pads and camptodactyly are overlapping symptoms associated with many genetic environmental factors. To the best of our knowledge, all reported cases epidermolytic palmoplantar keratoderma (EPPK) knuckle have been without accompanying camptodactyly. We here report a novel KRT9 mutation-EPPK family combined All EPPK-affected individuals in this southern Chinese pedigree suffered severe diffuse palmar plantar hyperkeratosis including hyperhidrosis cuticle splitting: 3 females presented...
Epidermolytic palmoplantar keratoderma (EPPK) is a relatively common autosomal-dominant skin disorder caused by mutations in the keratin 9 gene (KRT9), with few therapeutic options for affected so far. Here, we report knock-in transgenic mouse model that carried small insertion-deletion (indel) mutant of Krt9, c.434delAinsGGCT (p.Tyr144delinsTrpLeu), corresponding to human mutation KRT9/c.500delAinsGGCT (p.Tyr167delinsTrpLeu), which resulted EPPK-like phenotype weight-stress areas fore- and...