A5101655970- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- RNA Research and Splicing
- Circular RNAs in diseases
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Hematopoietic Stem Cell Transplantation
- Inflammasome and immune disorders
- Protein Degradation and Inhibitors
- Peroxisome Proliferator-Activated Receptors
- Cancer Diagnosis and Treatment
- Nerve injury and regeneration
- Adipokines, Inflammation, and Metabolic Diseases
- Electrospun Nanofibers in Biomedical Applications
- Cancer and Skin Lesions
- Chronic Lymphocytic Leukemia Research
- Blood groups and transfusion
- Tumors and Oncological Cases
National University of Singapore
2025
Affiliated Hospital of Jining Medical University
2017-2024
Shenzhen Pingle Orthopedic Hospital
2023
Guangzhou University of Chinese Medicine
2023
Macau University of Science and Technology
2023
Weatherford College
2022
Jining Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2017
Long noncoding RNAs (lncRNAs) are emerging as important regulators in mammalian development, but little is known about their roles monocyte/macrophage differentiation. Here we identified a long monocytic RNA (lnc-MC) that exhibits increased expression during differentiation of THP-1 and HL-60 cells well CD34(+) hematopoietic stem/progenitor (HSPCs) transcriptionally activated by PU.1. Gain- loss-of-function assays demonstrate lnc-MC promotes HSPCs. Mechanistic investigation reveals acts...
Pancreatic cancer patients are often resistant to chemotherapy treatment, which results in poor prognosis. The objective of this study was delineate the mechanism by miR-21 induces drug resistance 5-fluorouracil (5-FU) human pancreatic cells (PATU8988 and PANC-1). We report that PATU8988 5-FU express high levels comparison sensitive primary cells. Suppression expression 5-Fu-resistant can alleviate its resistance. Meanwhile, lentiviral vector-mediated overexpression not only conferred but...
MicroRNA-22 (miR-22) is emerging as a critical regulator in organ development and various cancers. However, its role normal hematopoiesis leukaemogenesis remains unclear. Here, we detected increased expression during monocyte/macrophage differentiation of HL-60, THP1 cells CD34+ hematopoietic stem/progenitor cells, confirmed that PU.1, key transcriptional factor for differentiation, responsible activation miR-22 the differentiation. By gain- loss-of-function experiments, demonstrated...
Abstract RNA binding proteins (RBPs)-mediated post-transcriptional control has been implicated in influencing various aspects of metabolism and playing important roles mammalian development pathological diseases. However, the functions specific RBPs molecular mechanisms through which they act monocyte/macrophage differentiation remain to be determined. In this study, bioinformatics analysis experimental validation, we identify that ZFP36L1, a member ZFP36 zinc finger protein family, exhibits...
<title>Abstract</title> Active repeating Fast Radio Bursts (FRBs), with their large number of bursts, burst energy distribution, and potential evolution, offer critical insights into the FRBs emission mechanisms. Traditional pipelines search for bursts through conducting dedispersion trials looking signals above certain fluence thresholds, both which could result in missing weak narrow-band bursts. In order to improve completeness set, we develop an End-to-end DedispersE-agnostic...
Abstract miRNAs are short, noncoding RNAs that regulate expression of target genes at post-transcriptional levels and function in many important cellular processes, including differentiation, proliferation, etc. In this study, we observed down-regulation miR-199a-5p during monocyte/macrophage differentiation HL-60 THP-1 cells, as well human CD34+ HSPCs. This resulted from the up-regulation PU.1 was demonstrated to transcription miR-199a-2 gene negatively. Overexpression by mimic transfection...
Mesenchymal stem cells (MSCs) have been widely used in regenerative medicine and cellular therapy due to their multi-lineage differentiation potential immunomodulatory function. The applicability of MSCs also depends on sources vivo functions. Here this study, we systematically compared the morphologic characteristics, immunophenotypes adipogenic derived from umbilical cord (UC), adipose tissue (Ad) bone marrow (BM). We found that three tissues-derived displayed decreased capacity order:...
Abstract High mobility group box 1 (HMGB1) is a non-histone nuclear protein which has been intensively studied in various physiological and pathological processes including leukemia. Here this study, we further demonstrated that HMGB1 presents higher expression the bone marrow mononuclear cells of acute myeloid leukemia (AML) patients compared with normal controls contributes to AML pathogenesis progression by inhibiting apoptosis, facilitating proliferation, inducing differentiation...
Abstract Autoimmune hemolytic anemia (AIHA) therapy may be associated with severe complications such as diabetes, hypertension, obesity, osteoporosis, peptic ulcers, infection, and some other diseases. To reduce those effects, we used low-dose rituximab, bortezomib dexamethasone (LowR-BD regimen) to treat AIHA. The purpose of this study was evaluate the efficacy safety regimen. Seven patients warm AIHA (wAIHA) admitted from March 2020 October were treated LowR-BD regimen: Rituximab 100 mg by...
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by abnormal cell proliferation, apoptosis repression and differentiation blockade of hematopoietic stem/progenitor cells. Developing identifying novel therapeutic agents to reverse the pathological processes AML are great significance. Here in this study, we found that fungus-derived histone deacetylase inhibitor, Apicidin, presents promising effect on inhibiting facilitating inducing Mechanistic...
Increased propensity of bone marrow-derived mesenchymal stem cells (BM-MSCs) toward adipogenic differentiation has been implicated in the fatty marrow and defective hematopoiesis aplastic anemia (AA). However, underlying molecular mechanism remains to be investigated. In this study, we found that microRNA 199a-5p (miR-199a-5p) exhibits significantly higher expression AA BM-MSCs compared with normal control is demonstrated facilitate through lentivirus-mediated miR-199a overexpression....
Increased propensity of bone marrow-derived mesenchymal stem cells (BM-MSCs) toward adipogenic differentiation at the expense osteogenesis has been implicated in obesity, diabetes, and age-related osteoporosis as well various hematopoietic disorders. Defining small molecules with role rectifying adipo-osteogenic imbalance is great significance. Here, we unexpectedly found that Chidamide, a selective histone deacetylases inhibitor, exhibited remarkably suppressive effect on vitro induced...
// Li Song 1 , Hai-Shuang Lin Jia-Nan Gong Hua Han 2 Xiao-Shuang Wang Rui Su Ming-Tai Chen Chao Shen Yan-Ni Ma Jia Yu and Jun-Wu Zhang The State Key Laboratory of Medical Molecular Biology, Department Biochemistry Institute Basic Sciences, Chinese Academy Sciences Peking Union College, Beijing 100005, China Obstetrics Gynecology, Hebei General Hospital, Shijiazhuang 050051, Correspondence to: Zhang, email: junwu_zhang@pumc.edu.cn Keywords: acute myeloid leukemia (AML), granulocytic...
Abstract Aplastic anaemia (AA) is a life‐threatening hematopoietic disorder characterized by hypoplasia and pancytopenia with increasing fat cells in the bone marrow (BM). The BM‐derived mesenchymal stem (MSCs) from AA are more susceptible to be induced into adipogenic differentiation compared that control, which may causatively associated fatty BM defective hematopoiesis of AA. Here this study, we first demonstrated levamisole displayed significant suppressive effect on vitro BM‐MSCs....
Occult breast cancer (OBC) is a rare type of without any symptoms in the and often presented with initial axillary lymph node metastasis or other metastases. The low incidence rates OBC make it great challenge to diagnose cure.Our case was 58-year-old female affected by dizziness fatigue for nearly month. Blood tests revealed anemia thrombocytopenia, pathological results bone marrow biopsy confirmed metastatic carcinoma.It diagnosed as an based on positive immunohistochemical staining...
Accumulating evidence indicates that mesenchymal stem cells (MSCs) have been widely used in tissue engineering and regenerative medicine due to their multilineage differentiation potentials. Recent studies show germ-like can also be derived from cells, such as human umbilical cord MSCs bone marrow vitro. However, whether adipose-derived (hAD-MSCs) induced into has never reported. In this study, we isolated hAD-MSCs confirmed characteristics were accordance with of established before. Germ...
Corilagin is the primary active component of Euphorbia phyllanthus plant and has significant anti‑cancer properties. However, biological effects mechanisms corilagin on acute myeloid leukemia (AML) have not been clarified. The Cell Counting Kit‑8 Carboxyfluorescein Diacetate Succinimidyl Ester assay results showed that significantly inhibited proliferation AML cell line HL‑60 in a time‑ dose‑dependent manner. Western blotting flow cytometry analysis were performed to determine levels...
To systematically screen and identify long noncoding RNA (lncRNA) associated with bone marrow adiposity changes in aplastic anemia (AA).
Zhilong Huoxue Tongyu capsule (ZL) is a Chinese patent medicine for treating cardio-cerebral diseases. However, the pharmacological mechanism by which it regulates blood lipids and treats atherosclerosis (AS) unclear. Therefore, purpose of this study to explore ZL inhibiting hyperlipidemia AS through NF-κB/NLRP3 signaling pathway.Fifty New Zealand white rabbits were divided into control, model, model + (3.12 g/kg/d, i.g.), atorvastatin (0.51 mg/kg/d, groups. Except control group, all other...