A5101860855- Gene expression and cancer classification
- Statistical Methods and Inference
- Advanced Causal Inference Techniques
- Bioinformatics and Genomic Networks
- Climate Change and Health Impacts
- Statistical Methods in Clinical Trials
- COVID-19 and Mental Health
- Healthcare Systems and Reforms
- Statistical Methods and Bayesian Inference
- Machine Learning in Bioinformatics
- Epigenetics and DNA Methylation
- Fault Detection and Control Systems
- Psoriasis: Treatment and Pathogenesis
- Building Energy and Comfort Optimization
- Trigeminal Neuralgia and Treatments
- Global Maternal and Child Health
- Pancreatic and Hepatic Oncology Research
- Geriatric Care and Nursing Homes
- Advanced Algorithms and Applications
- Vitamin D Research Studies
- Medical Research and Treatments
- Long-Term Effects of COVID-19
- Tuberculosis Research and Epidemiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
Deyang Stomatological Hospital
2023-2025
Hubei Zhongshan Hospital
2025
Wuhan University
2012-2025
Huazhong University of Science and Technology
2025
Union Hospital
2025
Peking University
2021-2025
Yale University
2007-2024
Northeastern University
2018-2024
Wuxi Municipal Product Quality Supervision and Inspection Institute
2024
Soochow University
2024
Personalized medicine has received increasing attention among statisticians, computer scientists, and clinical practitioners. A major component of personalized is the estimation individualized treatment rules (ITRs). Recently, Zhao et al. proposed outcome weighted learning (OWL) to construct ITRs that directly optimize outcome. Although OWL opens door introducing machine techniques optimal regimes, it still some problems in performance. (1) The estimated ITR affected by a simple shift (2)...
Vitamin D metabolites support innate immune responses to Mycobacterium tuberculosis. Data from phase 3, randomized, controlled trials of vitamin supplementation prevent tuberculosis infection are lacking.We randomly assigned children who had negative results for M. according the QuantiFERON-TB Gold In-Tube assay (QFT) receive a weekly oral dose either 14,000 IU D3 or placebo 3 years. The primary outcome was positive QFT result at 3-year follow-up, expressed as proportion children. Secondary...
Abstract Motivation: Given the thousands of genes and small number samples, gene selection has emerged as an important research problem in microarray data analysis. Support Vector Machine—Recursive Feature Elimination (SVM-RFE) is one a group recently described algorithms which represent stat-of-the-art for selection. Just like SVM itself, SVM-RFE was originally designed to solve binary problems. Several groups have extended multiclass problems using one-versus-all techniques. However,...
Objective To evaluate the service readiness of health facilities in Bangladesh, Haiti
Background: Contact tracing is a core element of the public health response to emerging infectious diseases including COVID-19. Better understanding implementation context contact for pandemics, individual- and systems-level predictors success, critical preparing future epidemics. Methods: We carried out prospective study an emergency volunteer program established in New Haven, Connecticut between April 4 May 19, 2020. assessed yield timeliness case outreach reference CDC benchmarks,...
Abstract Background Chronic inflammation may contribute to increased mortality risk in individuals with osteoarthritis (OA), but research on the prognostic value of inflammatory biomarkers is limited. We aimed evaluate associations systemic immune–inflammation index (SII) and response (SIRI) all-cause cardiovascular among US adults OA. Methods This cohort study included 3545 OA aged ≥ 20 years from National Health Nutrition Examination Survey 1999–2020. The SII SIRI were calculated using...
Abstract Motivation: The Illumina BeadArray is a popular platform for profiling DNA methylation, an important epigenetic event associated with gene silencing and chromosomal instability. However, current approaches rely on arbitrary detection P-value cutoff excluding probes samples from subsequent analysis as quality control step, which results in missing observations information loss. It desirable to have approach that incorporates the whole data, but accounts different of individual...
DNA methylation, an epigenetic alteration typically occurring early in cancer development, could aid the molecular diagnosis of melanoma. We determined technical feasibility for high-throughput DNA-methylation array-based profiling using formalin-fixed paraffin-embedded tissues selection candidate differences between melanomas and nevi. Promoter methylation was evaluated 27 common benign nevi 22 primary invasive a 1505 CpG site microarray. Unsupervised hierarchical clustering distinguished...
PURPOSE Current tools in predicting survival outcomes for patients with colon cancer predominantly rely on clinical and pathologic characteristics, but increasing evidence suggests that diet lifestyle habits are associated patient should be considered to enhance model accuracy. METHODS Using an adjuvant chemotherapy trial stage III (CALGB 89803), we developed prediction models of disease-free (DFS) overall by additionally incorporating self-reported nine factors. Both were assessed...
Pancreatic cancer is among the deadliest malignancies; however, genetic events that lead to pancreatic carcinogenesis in adults remain unclear. In vivo models which these alterations occur adult animals may more accurately reflect features of human cancer. this study, we demonstrate inactivation Cdkn2b (p15ink4b) necessary for induction by oncogenic KRASG12D expression and Tp53 Cdkn2a mouse ductal cells (P60 or older). overexpression activated transforming growth factor-β signaling CDKN2B,...
Background: With the anti-cancer efficacies of cold atmospheric plasma being increasingly recognized in vitro, a demand on creating an effective tool feasible for vivo animal treatment has emerged.Methods: Through use co-axial needles with different calibers diameter, we designed novel situ ejection source plasma, namely invivoPen, experiments.It punches just single pinhole that could considerably ease complexity operating small animals such as mouse.Results: We showed invivoPen deliver...
Motivation: One problem with discriminant analysis of DNA microarray data is that each sample represented by quite a large number genes, and many them are irrelevant, insignificant or redundant to the at hand. Methods for selecting important genes are, therefore, much significance in analysis. In present study, new criterion, called LS Bound measure, proposed address gene selection problem. The measure derived from leave-one-out procedure LS-SVMs (least squares support vector machines), as...
A bedside personalized ventilation (PV) system was investigated by experiments on human subjects including children, adults and elderly. Short-term exposure experiment first carried out to find the subjects’ perception of air movement temperature effect falling asleep. Through comparative analysis subjective questionnaires returned from participants objective physiological tests in all-night sleep experiments, influence this comfort quality obtained as well optimal operation parameters. For...
Exercise is significant for older adults to improve their poor health outcomes. It can delay weakness, enhance the quality of muscle and body balance, prevent adverse events. However, factors that hinder or promote exercise among frail nursing home residents are unclear. Few studies have investigated exercise-related experiences coping strategies adults, it necessary further understand overall situation adults. Therefore, this study aims obtain information about impact barriers facilitators...
Oral mucosal wounds can greatly affect overall patient health and interfere with eating speech functions. The intraoral environment provides an ideal milieu for bacterial growth proliferation, thereby increasing the risk of infection in oral wounds. In event wound infection, immune cells undergo a respiratory burst, leading to production substantial amount reactive oxygen species. Bacterial colonization excessive species induce adverse inflammatory responses, resulting delayed healing Cerium...
Chest pain is a common symptom with complex etiology involving multiple organs and systems. Cardiovascular, digestive respiratory diseases can cause chest pain. A single condition usually reformulates this symptom, but combination of conditions also it. This case reports 69-year-old male suffered from recurrent Coronary heart disease, gastroesophageal reflux disease left lung adenocarcinoma were diagnosed successively for nearly 1 year. The patients focus on one the medical staff neglects to...
Calcium phosphate cement provides a biomaterial that can be used for calvarial reconstruction in retrosigmoid craniectomy microvascular decompression (MVD). This study evaluates the outcomes of postoperative CSF leak and wound infection patients undergoing complete cranioplasty using calcium versus incomplete polyethylene titanium mesh following MVD.The authors evaluated 211 cases involving who underwent first-time craniectomies performed by single attending surgeon fortrigeminal neuralgia...
Phosphoprotein-binding domains (PPBDs) mediate many important cellular and molecular processes. Ten PPBDs have been known to exist in the human proteome, namely, 14-3-3, BRCT, C2, FHA, MH2, PBD, PTB, SH2, WD-40 WW. PepCyber:P ∼ PEP is a newly constructed database specialized documenting PPBD-containing proteins PPBD-mediated interactions. Our motivation provide research community with rich information source emphasizing reported, experimentally validated data for specific PPBD–PPEP This not...
OBJECTIVE Trigeminal neuralgia (TN) is characterized by intermittent, paroxysmal, and lancinating pain along the distribution of trigeminal nerve. Microvascular decompression (MVD) directly addresses compression The purpose this study was to determine whether patients undergoing MVD as their first surgical intervention experience greater control than who undergo subsequent MVD. METHODS A retrospective review patient records from 1998 2015 identified a total 942 with TN 500 underwent After...
In stepped wedge designs (SWD), clusters are randomized to the time period during which new patients will receive intervention under study in a sequential rollout over time. By study's end, at all intervention, eliminating ethical concerns related withholding potentially efficacious treatments. This is practical option many large-scale public health implementation settings. Little statistical theory for these exists binary outcomes. To address this, we utilized maximum likelihood approach...