A5024899479- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Diseases and Immunity
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Gout, Hyperuricemia, Uric Acid
- Renal Diseases and Glomerulopathies
- Inflammation biomarkers and pathways
- Platelet Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Lymphoma Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Hematological disorders and diagnostics
- Otitis Media and Relapsing Polychondritis
- Sports Dynamics and Biomechanics
- Viral Infections and Immunology Research
First Affiliated Hospital of Soochow University
2020-2025
Soochow University
2020-2025
Mudanjiang Normal University
2024
Shanghai Jiao Tong University
2017-2024
Shanghai Children's Medical Center
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2023
Peking Union Medical College Hospital
2010-2023
Heilongjiang Bayi Agricultural University
2022-2023
Xinxiang Medical University
2023
Ruijin Hospital
2017-2019
To compare the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) with methotrexate (MTX) in treatment active rheumatoid arthritis (RA).Design: a multicentre, open-label, randomised controlled trial. All patients were assessed by trained investigators who unaware therapeutic regimen.207 RA randomly allocated (1:1:1) to MTX 12.5 mg once week, or TwHF 20 three times day, two combination. At week 12, if reduction 28-joint count Disease Activity Score (DAS28) was <30% monotherapy...
Adult-onset Still's disease (AOSD) is a systemic inflammatory characterized by neutrophilia and NLRP3 inflammasome macrophage activation. We investigated the role of neutrophil extracellular traps (NETs) in pathogenesis AOSD, explored effect NETs on activating proinflammatory macrophages. The sera 73 AOSD patients 40 healthy controls were used to detect level cell-free DNA NET-DNA complexes. NET formation ex vivo was analyzed using immunofluorescence flow plates. activation THP-1 cells...
Abstract Background: The aim of the study was to determine prevalence and clinical associations antiphosphatidylserine/prothrombin antibodies (aPS/PT) with thrombosis pregnancy loss in Chinese patients antiphospholipid syndrome (APS) seronegative APS (SNAPS). Methods: One hundred eighty six (67 primary, 119 secondary), 48 SNAPS, 176 disease controls (79 systemic lupus erythematosus [SLE], 29 Sjogren’s [SS], 30 ankylosing spondylitis [AS], 38 rheumatoid arthritis [RA]) 90 healthy donors were...
Background The neutrophil-to-lymphocyte ratio (NLR) is recognized as a biomarker for systemic inflammation and immune activation. However, its connection with the mortality risk in individuals rheumatoid arthritis (RA) not well understood. This study aimed to investigate association between NLR all-cause cardiovascular U.S. adults RA. Methods Data were gathered from National Health Nutrition Examination Survey (NHANES) cycles spanning 1999 March 2020. We included aged ≥20 years. was computed...
Abstract Background Chronic inflammation may contribute to increased mortality risk in individuals with osteoarthritis (OA), but research on the prognostic value of inflammatory biomarkers is limited. We aimed evaluate associations systemic immune–inflammation index (SII) and response (SIRI) all-cause cardiovascular among US adults OA. Methods This cohort study included 3545 OA aged ≥ 20 years from National Health Nutrition Examination Survey 1999–2020. The SII SIRI were calculated using...
Objective Patients with rheumatoid arthritis (RA) are at risk to develop RA-associated interstitial lung disease (RA-ILD). This retrospective study aimed investigate the potential association of positivity serum anti-cyclic citrullinated peptide antibody (anti-CCP2) and factor (RF) RA-ILD in RA patients. Methods A total 285 patients were recruited inpatient service Peking Union Medical College Hospital China between 2004 2013. Individual evaluated for evidence ILD. The concentrations...
<h3>Background</h3> The study aimed to evaluate the use of positron emission tomography/computed tomography (PET/CT) with <sup>68</sup>Ga-PRGD2 as tracer for imaging synovial angiogenesis in patients rheumatoid arthritis (RA). <h3>Methods</h3> Twenty untreated active RA underwent PET/CT and <sup>18</sup>F-FDG before treatment; two osteoarthritis served controls. Among 20 RA, 12 repeated evaluations after 3-month treatment. image findings were correlated core variables disease activity,...
Objective The prevalence of hyperuricemia and hypertension is steadily increasing, these conditions often share common risk factors. This study aimed to investigate the association among hyperuricemia, hypertension, all-cause mortality in a nationally representative U.S. population. Methods Data for 38,644 participants were obtained from National Health Nutrition Examination Survey (NHANES) 2001–2018. Hyperuricemia was defined as serum urate concentration &gt;420 μmol/L men &gt;360...
Abstract Background Hyperuricemia is associated with increased systemic inflammation. The immune‐inflammation index (SII) and inflammation response (SIRI) are novel markers prognostic markers. However, no studies have evaluated the association between SII/SIRI mortality risk in individuals hyperuricemia. This study aimed to investigate predictive value of SII SIRI for all‐cause cardiovascular a large cohort hyperuricemia patients. Methods We conducted prospective using data from National...
2023年肺炎支原体肺炎（MPP）在全国流行，国家卫生健康委员会于2023年2月发布“儿童肺炎支原体肺炎诊治指南”，但在实施过程中仍需要根据目前MPP特点，对重要诊治环节更加具体地指导和建议，现对MPP早期诊断方法、重症MPP判断依据和预警指标、各类抗支原体药物适应证、大环内酯类药物无反应性处理原则、糖皮质激素和支气管镜的应用问题等进行了专家释疑。.
Interleukin (IL)-37 has been known to play an immunosuppressive role in various inflammatory disorders, but whether it participates the regulation of pathogenesis adult-onset Still’s disease (AOSD) not investigated. In this study, we examined serum IL-37 levels and their clinical association with AOSD, explored anti-inflammatory effects on peripheral blood mononuclear cells (PBMCs) from patients AOSD. Blood samples were collected 62 AOSD 50 healthy control subjects (HC). The determined using...
Programmed cell death protein 1 (PD-1) plays an important role in immune response regulation as a co-inhibitory signal during T activation. However, there is little known about the serum autoantibody profile of PD-1 systemic lupus erythematosus (SLE), disease characterized by breakdown tolerance to self-antigens and excessive production autoantibodies. Thus, we aim investigate levels function anti-PD-1 patients with new-onset SLE. Serum IgG IgM isotypes were detected SLE (n = 90), rheumatoid...
Background: PRC1, a microtubules(MTs)-associated protein, is essential in the mitosis and cell cycle regulation.It has been recently linked to chemoresistance tumorigenesis.The current study sought explore role of PRC1 on postoperative prognosis hepatocellular carcinoma(HCC).Methods: was transfected into HCC cells detect its effects 5-fluorouracil vitro vivo.This also investigated impact 5-FU-induced G2/M phase arrest potential molecular mechanism.Surgical specimens from patients were...
Objective. CD200/CD200R1 signalling has an immunoregulatory effect on the activation threshold of inflammatory immune response and maintains homeostasis. In this study we evaluated status interaction in patients with RA.
Abstract Increased concentrations of free fatty acids (FFAs) induce reactive oxygen species (ROSs) generation and endoplasmic reticulum (ER) stress, thus, increasing the risk liver in dairy cows during periparturient period. In non-ruminants, Taraxasterol (Tara; a pentacyclic triterpenoid found medicinal plants) plays an important role anti-inflammatory antioxidant reactions. Whether Tara can alleviate or prevent ruminants is unknown. We addressed whether supply could dampen lipid...