A5063318273- Malaria Research and Control
- Mosquito-borne diseases and control
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Viral Infections and Outbreaks Research
- Adversarial Robustness in Machine Learning
- COVID-19 Digital Contact Tracing
- Metabolism, Diabetes, and Cancer
- Lung Cancer Treatments and Mutations
- vaccines and immunoinformatics approaches
- COVID-19 epidemiological studies
- Model Reduction and Neural Networks
- Anomaly Detection Techniques and Applications
- Computational Drug Discovery Methods
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Parasites and Host Interactions
- Neural Networks and Applications
- Drug Transport and Resistance Mechanisms
- HIV/AIDS drug development and treatment
- ATP Synthase and ATPases Research
- Trypanosoma species research and implications
- Cardiovascular and Diving-Related Complications
- High Altitude and Hypoxia
- Spectroscopy and Chemometric Analyses
Yale University
2017-2025
MIT Lincoln Laboratory
2025
United States Naval Academy
2021
Massachusetts General Hospital
2021
Harvard University
2021
Beth Israel Deaconess Medical Center
2021
The University of Texas at Austin
2021
Yale New Haven Health System
2020
Colorado State University
2020
Integrated Radiological Services (United Kingdom)
2020
Abstract Overexpression of NQO1 is associated with poor prognosis in human cancers including breast, colon, cervix, lung and pancreas. Yet, the molecular mechanisms underlying pro-tumorigenic capacities have not been fully elucidated. Here we show a previously undescribed function for stabilizing HIF-1α, master transcription factor oxygen homeostasis that has implicated survival, proliferation malignant progression cancers. We demonstrate directly binds to oxygen-dependent domain HIF-1α...
Abstract Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small lung cancer (NSCLC) distinct in their histological, molecular clinical presentation. However, metabolic signatures specific to individual NSCLC remain unknown. Here, we perform an integrative analysis human tumour samples, patient-derived xenografts, murine model NSCLC, lines The Cancer Genome Atlas (TCGA) reveal a markedly elevated expression GLUT1 glucose transporter SqCC, which...
Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly activated myofibroblasts are primary pathological driver progression, yet how various microenvironmental influences, such as hypoxia, contribute to their sustained activation and differentiation is poorly understood. As a defining feature hypoxia its impact on cellular metabolism, we sought investigate hypoxia-induced metabolic reprogramming affects myofibroblast test preclinical efficacy targeting...
Squamous cell carcinoma (SCC), a malignancy arising across multiple anatomical sites, is responsible for significant cancer mortality due to insufficient therapeutic options. Here, we identify exceptional glucose reliance among SCCs dictated by hyperactive GLUT1-mediated influx. Mechanistically, squamous lineage transcription factors p63 and SOX2 transactivate the intronic enhancer cluster of SLC2A1. Elevated influx fuels generation NADPH GSH, thereby heightening anti-oxidative capacity in...
Background: Contact tracing is a core element of the public health response to emerging infectious diseases including COVID-19. Better understanding implementation context contact for pandemics, individual- and systems-level predictors success, critical preparing future epidemics. Methods: We carried out prospective study an emergency volunteer program established in New Haven, Connecticut between April 4 May 19, 2020. assessed yield timeliness case outreach reference CDC benchmarks,...
Abstract Standard diagnostics used in longitudinal antimalarial studies are unable to characterize the complexity of submicroscopic parasite dynamics, particularly high transmission settings. We use molecular markers and amplicon sequencing post-treatment stage-specific malaria dynamics during a 42 day randomized trial 3- versus 5 artemether-lumefantrine 303 children with without HIV (ClinicalTrials.gov number NCT03453840). The prevalence parasite-derived 18S rRNA is >70% throughout...
Meshes are used to represent complex objects in high fidelity physics simulators across a variety of domains, such as radar sensing and aerodynamics. There is growing interest using neural networks accelerate simulations, also body work on applying directly irregular mesh data. Since multiple topologies can the same object, augmentation typically required handle topological variation when training networks. Due sensitivity small changes shape, it challenging use these augmentations...
Abstract Malaria and HIV co‐infection are prevalent in sub‐Saharan Africa causing significant drug interactions with co‐treatment. We previously reported a 30%‐70% reduction exposure to the standard 3‐day (6‐dose) artemether‐lumefantrine (AL) treatment for malaria when given efavirenz‐based therapy, impacting reinfection risk. conducted prospective, randomized study comparing regimen an extended 5‐day (10‐dose) pharmacokinetic sampling artemether, dihydroartemisinin, lumefantrine,...
Contact tracing is an important tool for suppressing COVID-19 but has been difficult to adapt the conditions of a public health emergency. This study explored experiences and perspectives volunteer contact tracers in order identify facilitators, challenges, novel solutions implementing tracing.As part evaluate emergently established program New Haven, Connecticut, April-June 2020, we conducted focus groups with 36 tracers, thematically analyzed data, synthesized findings using RE-AIM...
Contact tracing was one of the core public health strategies implemented during first months COVID-19 pandemic. In this essay, we describe rapid establishment a volunteer contact program in New Haven, Connecticut. We successes and challenges that were faced. Going forward, efforts can best be supported by increased funding to state local departments for stable workforce use evidence-based technological innovations.
Abstract Background Artemether-lumefantrine (AL) is the most widely used artemisinin-based combination therapy in Sub-Saharan Africa and threatened by emergence of artemisinin resistance. Dosing suboptimal young children. We hypothesized that extending AL duration will improve exposure reduce reinfection risks. Methods conducted a prospective, randomized, open-label pharmacokinetic/pharmacodynamic study extended children with malaria high-transmission rural Uganda. Children received 3-day...
Artificial Intelligence (AI) has the opportunity to revolutionize way United States Department of Defense (DoD) and Community (IC) address challenges evolving threats, data deluge, rapid courses action. Developing an end-to-end artificial intelligence system involves parallel development different pieces that must work together in order provide capabilities can be used by decision makers, warfighters analysts. These include collection, conditioning, algorithms, computing, robust...
Cancer cells consume high amounts of glucose for their cellular bioenergetic and anabolic requirements, relying on to fuel growth. We recently reported that lung squamous cell carcinoma, a major subtype non-small cancer (NSCLC), exhibits remarkably elevated transporter GLUT1 (encoded by SLC2A1) expression dependency, while another NSCLC, adenocarcinoma, shows significant independence. Our findings highlight the metabolic heterogeneity metabolism among subtypes, which can be exploited...
Artemisinin-based combination therapies (ACTs) are the primary treatment for malaria. It is essential to characterize pharmacokinetics (PKs) and pharmacodynamics (PDs) of ACTs in vulnerable populations at risk suboptimal dosing. We developed a population PK/PD model using data from our previous study artemether-lumefantrine HIV-uninfected HIV-infected children living high-transmission region Uganda. were on efavirenz-, nevirapine-, or lopinavir-ritonavir-based antiretroviral regimens, with...
The recent stall in the global reduction of malaria deaths has made development a highly effective vaccine essential. A major challenge to developing an efficacious is extensive diversity Plasmodium falciparum antigens. While genetic plays role immune evasion and barrier both natural vaccine-induced protective immunity, it been under-prioritized evaluation candidates. This study uses genomic approaches evaluate next generation candidate PfRh5. We used targeted deep amplicon sequencing...
Responsible Artificial Intelligence (AI) - the practice of developing, evaluating, and maintaining accurate AI systems that also exhibit essential properties such as robustness explainability represents a multifaceted challenge often stretches standard machine learning tooling, frameworks, testing methods beyond their limits. In this paper, we present two new software libraries hydra-zen rAI-toolbox address critical needs for responsible engineering. dramatically simplifies process making...
Abstract Background Since 2014, seasonal malaria chemoprevention (SMC) with amodiaquine–sulfadoxine–pyrimethamine (AQ–SP) has been implemented on a large scale during the high transmission season in Burkina Faso. This paper reports prevalence of microscopic and submicroscopic infection at outset after first round SMC children under 5 years old Bama, Faso, as well host parasite factors involved mediating efficacy tolerability SMC. Methods Two sequential cross-sectional surveys were conducted...
BACKGROUND. Primary colon cancer location affects survival of patients with metastatic colorectal (mCRC). Outcomes based on primary tumor after salvage hepatic radioembolization 90Y resin microspheres are not well studied. OBJECTIVE. The objectives this study to assess the outcomes advanced chemorefractory mCRC treated radioembolization, as stratified by location, and explore potential factors that predictive survival. METHODS. A total 99 who had progressive liver metastases while receiving...
Abstract Background: Since 2014, seasonal malaria chemoprevention (SMC) with amodiaquine-sulfadoxine-pyrimethamine (AQ-SP) has been implemented on a large scale during the high transmission season in Burkina Faso. This paper reports prevalence of microscopic and submicroscopic infection at outset after first round SMC children under five years old Bama, Faso, as well host parasite factors involved mediating efficacy tolerability SMC. Methods: Two sequential cross-sectional surveys were...
Abstract Background Urban malaria has received insufficient attention in the literature. The prevalence and clinical characteristics of Plasmodium falciparum infection amongst patients presenting with suspected were investigated at a major urban hospital Douala, Cameroon particular focus on anaemia. Methods A cross-sectional, 18-week demographic survey was conducted to Emergency Department Douala Military Hospital malaria, largely defined by presence or recent history fever. Venous samples...