A5100320691- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cellular Mechanics and Interactions
- Cancer, Hypoxia, and Metabolism
- Retinoids in leukemia and cellular processes
- Cell Adhesion Molecules Research
- Traditional Chinese Medicine Analysis
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- RNA Research and Splicing
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Protein Tyrosine Phosphatases
- Bone and Joint Diseases
- interferon and immune responses
- Antioxidant Activity and Oxidative Stress
- Protease and Inhibitor Mechanisms
- Cancer-related Molecular Pathways
- Traditional Chinese Medicine Studies
- Hematological disorders and diagnostics
- Angiogenesis and VEGF in Cancer
- Asthma and respiratory diseases
- ATP Synthase and ATPases Research
Karolinska Institutet
2016-2024
Peking University
2016-2024
Peking University People's Hospital
2016-2024
Hubei University of Medicine
2024
Capital Medical University
2019-2024
Capital University
2024
Chinese PLA General Hospital
2024
Weifang Medical University
2024
Children's Hospital of Zhejiang University
2022-2024
Huashan Hospital
2018-2023
MicroRNA-21 (miR-21) has been demonstrated to play an important role in carcinogenesis; however, its mechanism of action colorectal cancer (CRC) not fully elucidated. The aim the present study was explore oncogenic function miR-21 and molecular CRC.A total 105 paired tumor tumor-adjacent normal tissue specimens from CRC patients two cell lines (HCT-116 SW480) were studied. protein mRNA expression levels PTEN examined using western blot analysis real-time reverse transcription-PCR (qRT-PCR)....
Background & AimsmicroRNAs (miRNAs) have been reported to regulate angiogenesis by down-regulating the expression of pro-angiogenic or anti-angiogenic factors. The aims this study were investigate whether miR-26a inhibited vascular endothelial growth factor A (VEGFA) and its clinical relevance in hepatocellular carcinoma (HCC). MethodsThe was modified HepG2 HCCLM3 cell lines respectively, a panel angiogenic factors measured real-time PCR cells. luciferase reporter assay used validate target...
Pancreatic cancer patients are often resistant to chemotherapy treatment, which results in poor prognosis. The objective of this study was delineate the mechanism by miR-21 induces drug resistance 5-fluorouracil (5-FU) human pancreatic cells (PATU8988 and PANC-1). We report that PATU8988 5-FU express high levels comparison sensitive primary cells. Suppression expression 5-Fu-resistant can alleviate its resistance. Meanwhile, lentiviral vector-mediated overexpression not only conferred but...
Abstract The global morbidity and mortality of colorectal cancer (CRC) are ranked the third among gastrointestinal tumors in world. MiR-451a is associated with several types cancer, including CRC. However, roles mechanisms miR-451a CRC have not been elucidated. BAP31 a predicted target gene our suppression subtractive hybridization library. Its relationship function unclear. We hypothesized that could induce apoptosis through suppressing Immunohistochemistry real-time PCR were used to...
Emerging evidence suggests that early-life (in-utero and first-year since birth) exposure to ambient PM2.5 is a risk factor for asthma onset exacerbation among children, while the hazards caused by compositions remain largely unknown. To examine potential associations of exposures mass its major chemical constituents with childhood wheezing. By conducting Phase II China, Children, Homes, Health study, we investigated 30,325 preschool children aged 3–6 years during 2019–2020 in mainland...
Endothelial cells are constantly exposed to mechanical forces in the form of fluid shear stress, extracellular stiffness, and cyclic strain. The mechanoresponsive activity YAP (Yes-associated protein) its role vascular development well described; however, whether changes transcription or epigenetic regulation involved these processes remains unanswered. Furthermore, how transduced nucleus drive transcriptional reprogramming endothelial is poorly understood. target gene,
Abstract Background Recent evidence has accumulated that MicroRNA (miRNA) dysregulation occurs in the majority of human malignancies including acute myeloid leukemia (AML) and may contribute to onco-/leukemo-genesis. Methods The expression levels miR-370 FoxM1 were assessed 48 newly diagnosed AML patients, 40 patients 1 st complete remission (CR) 21 healthy controls. Quantitative real-time PCR, western blots, colony formation assay, β-Galactosidase ( SA - β-Gal) staining used characterize...
Fibronectin (Fn) is an extracellular matrix protein that orchestrates complex cell adhesion and signaling through surface integrin receptors during tissue development, remodeling, disease, such as fibrosis. Fn sensitive to mechanical forces in its tandem type III repeats, resulting extensive molecular enlongation. As such, it has long been hypothesized cell- tissue-derived may activate "integrin switch" within the critical integrin-binding ninth 10th repeats—conferring differential...
Cancer stem cells (CSCs) play a key role in the posthepatectomy recurrence of hepatocellular carcinoma (HCC). CD133+ HCC exhibit liver CSC–like properties, and CSC differentiation–inducing therapy may lead these to lose their self-renewal ability induce terminal differentiation, which turn allow malignant potential be controlled. Because arsenic trioxide (As2O3) increases remission rates prolongs survival among patients with acute promyelocytic leukemia by inducing differentiation apoptosis...
Arsenic combined with all-trans retinoic acid (ATRA) is the standard of care for adult acute promyelocytic leukemia (APL). However, safety and effectiveness this treatment in pediatric patients APL have not been reported on basis larger sample sizes.We conducted a multicenter trial at 38 hospitals China. Patients newly diagnosed were stratified into two risk groups according to baseline WBC count FLT3-ITD mutation. ATRA plus arsenic trioxide or oral without chemotherapy administered...
Summary Non-muscle myosin heavy chain IIA (NMMHC IIA) has been shown to be involved in thrombus formation and inflammatory microparticle release endothelial cells. However, the role of NMMHC regulating expression tissue factor (TF) deep venous thrombosis remains elucidated. In present study, cells were stimulated with tumour necrosis factor-α (TNF-α) induce TF expression. Pretreatment II inhibitor blebbistatin suppressed mRNA protein expressions as well procoagulant activity a dose-dependent...
Epithelial‐to‐mesenchymal transition (EMT) has been implicated in embryonic development and various pathological events. However, the involvement of microRNA process EMT remains to be fully defined hepatocyte. ZEB1 is a well‐known transcriptional repressor E‐cadherin plays major role triggering during organ fibrosis cancer cell metastasis. Computational target predictions detect conserved sequence matching miR‐101 3′UTR mRNA. Our results confirm that suppresses expression by targeting...