A5100694972- Breast Cancer Treatment Studies
- Inflammasome and immune disorders
- Advanced Breast Cancer Therapies
- Pleural and Pulmonary Diseases
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Systemic Sclerosis and Related Diseases
- interferon and immune responses
- Ectopic Pregnancy Diagnosis and Management
- Immune Response and Inflammation
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Maternal and fetal healthcare
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Inflammatory Myopathies and Dermatomyositis
- Air Quality and Health Impacts
- 14-3-3 protein interactions
- Toxoplasma gondii Research Studies
Central South University
2008-2025
Texas A&M University
2025
National Chung Hsing University
2021-2025
Third Xiangya Hospital
2023-2025
Shenzhen University
2017-2025
Wuhan University of Science and Technology
2024
Hunan Provincial Center for Disease Control and Prevention
2024
Shanghai Jiao Tong University
2020-2023
Ruijin Hospital
2020-2023
Zhangzhou Municipal Hospital of Fujian Province
2016-2023
Exosomes secreted by tumor cells could serve as a promising immunotherapeutic vaccine. Heat shock proteins (HSP) induced in heat are molecular chaperones with potent adjuvant activity the induction of antigen-specific T cell responses. To improve exosome-based vaccines, we have investigated efficacy exosomes derived from heat-shocked mouse B lymphoma (HS-Exo) antitumor immune We found that HS-Exo, compared control same (Exo), contain more HSP60 and HSP90 increased amounts molecules involved...
The Toll-like receptor (TLR)4 complex, TLR4/MD-2, plays an important role in the inflammatory response against lipopolysaccharide, a ubiquitous membrane component Gram-negative bacteria. Ligand recognition by TLR4 initiates multiple intracellular signaling pathways, leading to production of proinflammatory mediators and type I IFN. interaction also leads internalization surface complex into lysosomes, degradation termination LPS response. However, level is maintained via continuous...
Abstract Background Human epidermal growth factor receptor 2 (HER2) low breast cancer was considered as a distinct subtype different from HER2-zero cancer. Our study aimed to investigate the prognostic values of clinicopathological features and recurrence score (RS) in HER2-low hormone (HR)-positive patients. Methods A total 2099 HR + primary female patients diagnosed between Jan 2009 2019 were collected. Tumors with immunohistochemistry 1 /2 negative situ hybridization results defined...
The NLRP3 inflammasome is involved in a diverse range of inflammatory diseases. activation inflammasomes must be tightly regulated to prevent excessive inflammation, and the protein ubiquitination system reported one ways which regulated. However, deubiquitination regulatory mechanisms remain elusive. Here, we demonstrated that USP22 (ubiquitin specific peptidase 22) promotes degradation inhibits activation. deficiency or vivo silencing significantly increases alum-induced peritonitis...
Fibrotic animal models are critical for the pathogenesis investigations and drug explorations in systemic sclerosis (SSc). The bleomycin (BLM)-induced mouse model is classical most widely used fibrosis model. However, traditional subcutaneous injection of BLM rarely induced diffuse skin lung lesions. Hypochlorous acid (HOCl)-induced mice a more representative that have cutaneous lesions, renal involvement. fibrotic immunological features this not fully elucidated. Here, we injected BALB/c...
Muscle cell necrosis is the most common pathological manifestation of idiopathic inflammatory myopathies. Evidence suggests that glycolysis might participate in it. However, mechanism unclear. This study aimed to determine role muscle damage occurs DM/PM.Mass spectrometry was performed on lesions from DM/PM and control subjects. The expression levels pyruvate kinase isozyme M2 (PKM2), nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3)...
Purpose: This study aims to determine the impact of preconception paternal alcohol consumption (PPAC) on retinal function and morphology in PPAC-offspring. Fetal spectrum disorder (FASD)–related ocular defects caused by maternal exposure has been well investigated, but influence PPAC offspring eyes remains unknown. Methods: Adult C57BL/6J male mice were exposed either 10% ethanol or water (control) for six weeks bred naïve females. Dark-adapted light responses at two, four, months old...
Abstract PTEN-induced kinase-1 (PINK1) is a crucial player in selective clearance of damaged mitochondria via the autophagy-lysosome pathway, process termed mitophagy. Previous studies on PINK1 mainly focused its post-translational modifications, while transcriptional regulation much less understood. Herein, we reported novel mechanism control transcription by SMAD Family Member 3 (SMAD3), an essential component transforming growth factor beta (TGFβ)-SMAD signaling pathway. First, observed...
Objective Renal tubular damage, a pivotal pathological feature of chronic kidney disease (CKD), predicts progression. While extreme nighttime sleep duration is linked to glomerular injury by prior studies, its impact on damage remains unclear. Given that 7–9 h per night widely recommended for maintaining overall health, this study aimed assess whether long associated with renal using both observational and genetic evidence.
Inflammatory bowel diseases (IBDs) are increasingly common characterized by chronic and relapsing inflammation of the gastrointestinal tract. NLRP3 might be a crucial regulator homeostatic balance intestine, but its upregulation leads to pyroptosis. Munronoid I is extracted purified from Munronia sinica , which has shown an anti-inflammatory effect, efficacy in IBD remains unproven. In this study, we attempted determine effect on regulate inflammasome activation pyroptosis IBD. Our data...
The gut microbiota is known to have significant involvement in the regulation of lipogenesis and adipogenesis, yet mechanisms responsible for this relationship remain poorly understood. current study aims provide insight into potential by which modulates chickens. Using chickens fed with a normal-fat diet (NFD, n = 5) high-fat (HFD, 5), we analyzed correlation between microbiota, cecal metabolomics, 16s rRNA sequencing, miRNA mRNA sequencing as well targeted metabolomics analysis....
Fine particulate matter (PM2.5)-related health issues have received increasing attention as a worldwide public problem, and PM2.5-related chronic kidney disease (CKD) has been emerging over the years. Limited research focused on mechanism of PM2.5-induced disease. To investigate impact PM2.5 its potential mechanism, we generated PM2.5-exposed C57BL/6 mouse model by using Shanghai Meteorological Environment Animal Exposure System (Shanghai-METAS) for 12 weeks, urine, blood tissues were...
PTP1B (protein tyrosine phosphatase 1B) is a negative regulator of IR (insulin receptor) activation and glucose homoeostasis, but the precise molecular mechanisms governing substrate selectivity regulation insulin signalling remain unclear. In present study we have taken advantage Drosophila as model organism to establish role SH3 (Src homology 3)/SH2 adaptor protein Dock (Dreadlocks) its mammalian counterpart Nck in by PTPs. We demonstrate that orthologue PTP61F dephosphorylates S2 cells...
Current treatment for complex and large-scale volumetric muscle loss (VML) injuries remains a limited success have substantial disadvantages, due to the irreversible of mass, slow regeneration, rapid formation non-functional fibrosis scars. These VML are accompanied by denervation destruction native vasculature which increases difficulties in functional restoration muscle. Here, reconstruction vascular network at injury site was offered as possible solution improving repair defects through...
While the higher assay sensitivity makes orthogonal catalytic DNA nanomachines promising for imaging analysis in living biosamples, absence of specific recognition components and persistent "always-on" state biomolecular identification hinder their further application. Hereby, we establish an endogenous mRNA (mRNA)-stimulative self-enhanced nanomachine mediated by near-infrared (NIR) light. Initially, a hairpin assembly entropy-driven catalysis cascaded circuit is equipped with component to...