A5102918748- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Immune cells in cancer
- RNA modifications and cancer
- CAR-T cell therapy research
- Immune Response and Inflammation
- Effects and risks of endocrine disrupting chemicals
- Asthma and respiratory diseases
- Cancer, Hypoxia, and Metabolism
- Ovarian cancer diagnosis and treatment
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Sirtuins and Resveratrol in Medicine
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- Vitamin D Research Studies
- Lung Cancer Research Studies
- Cytokine Signaling Pathways and Interactions
- Calcium signaling and nucleotide metabolism
Women's Hospital, School of Medicine, Zhejiang University
2018-2025
Second Hospital of Shandong University
2025
Zhejiang University
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Zhejiang Cancer Hospital
2024
First Affiliated Hospital Zhejiang University
2023
Public Health Department
2022
Women's Hospital
2022
Hangzhou First People's Hospital
2022
Tiande (China)
2013
The function of a new long non-coding RNA linc00673 remains unclear. While identified as an oncogenic player in non-small cell lung cancer (NSCLC), was found to be anti-oncogenic pancreatic ductal adenocarcinoma (PDAC). However whether regulated malignancy and epithelial mesenchymal transition (EMT) has not been characterized. Cell proliferation assessed using CCK-8 EdU assays, migration invasion were scratch assays transwell assays. Epithelial examined western blot, qRT-PCR...
Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease. Accumulating evidence suggests that is a tumor suppressor, but the underlying mechanism poorly understood. Here we show an for hypoxia-inducible factor 1α (HIF-1α). interacts with HIF-1α and promotes degradation through ubiquitination, which turn inhibits metastasis of breast cancer cells. downregulation cells metastasis, can be inhibited by targeting RNA interference or small-molecule inhibitor YC-1....
Autophagy is a catabolic process in response to starvation or other stress conditions sustain cellular homeostasis. At present, histone deacetylase inhibitors (HDACIs) are known induce autophagy cells through inhibition of mechanistic target rapamycin (MTOR) pathway. FOXO1, an important transcription factor regulated by AKT, also play role induction. the FOXO1 HDACIs-induced has not been reported. In this study, we first observed that HDACIs increased expression at mRNA and protein level....
Curcumin is a hydrophobic polyphenol derived from the herb Curcumalonga and its wide spectrum of pharmacological activities has been widely studied. It reported that can induce autophagy through inhibition Akt-mTOR pathway. However, effect on lysosome remains largely elusive. In this study, we first found treatment enhances autophagic flux in both human colon cancer HCT116 cells mouse embryonic fibroblasts (MEFs). Moreover, promotes lysosomal function, evidenced by increased acidification...
Phthalate ester plasticizers are used to improve the plasticity and strength of plastics. One most widely studied, di-2-ethylhexyl phthalate (DEHP), has been labeled as an endocrine disruptor. The major toxic metabolic derivative DEHP, mono-2-ethylhexyl (MEHP), is capable interfering with mitochondrial function, but its mechanism action on mitophagy remains elusive. Here, we report that MEHP exacerbates cytotoxicity by amplifying PINK1-Parkin-mediated pathway. First, exacerbated damage...
Spautin-1 is a well-known macroautophagy/autophagy inhibitor via suppressing the deubiquitinases USP10 and USP13 promoting degradation of PIK3C3/VPS34-BECN1 complex, while its effect on selective autophagy remains poorly understood. Mitophagy form for removal damaged superfluous mitochondria autophagy-lysosome pathway. Here, we report surprising discovery that, spautin-1 as an effective inhibitor, it promotes PINK1-PRKN-dependent mitophagy induced by mitochondrial damage agents....
Suppression of autophagy has been increasingly recognized as a novel cancer therapeutic approach. Andrographolide (Andro), diterpenoid lactone isolated from an herbal plant Andrographis paniculata, is known to possess anti-inflammatory and anticancer activity. In this study, we sought examine the effect Andro on autophagy, evaluate whether such relevant sensitization apoptosis induced by DNA damage agents in cells. First, found that able significantly enhance autophagic markers various cell...
The xenoestrogen bisphenol A (BPA) is a synthetic endocrine disrupting chemical, having the potential to increase risk of hormone-dependent ovarian cancer. Thus, deeper understanding molecular and cellular mechanisms urgently required in novel cell models cancer which express estrogen receptors. To understand possible underlying effects BPA, human adenocarcinoma SKOV3 cells were exposed BPA (10 or 100 nM) 0.1% DMSO for 24 h, then global gene expression profile was determined by...
Abstract Th17 cells that produce IL-17 have been found to participate in the development of allergy-triggered asthma. However, whether they play a causative role pathogenesis airway remodeling chronic asthma remains unclear. In this study, we investigated and possible involvement epidermal growth factor (EGF) receptor signals downstream Th17. We established C57BL/6 mouse model prolonged allergen challenge exhibits many characteristics remodeling. Prolonged induced progressive increase number...
SCD1 (stearoyl-coenzyme A desaturase 1) is an endoplasmic reticulum-bound enzyme that catalyzes the formation of first double bond at cis-Δ9 position saturated fatty acids (SFA) to form monounsaturated (MUFA). Increasing evidence indicates autophagy plays important role in regulating lipid metabolism, while little known about whether key enzymes lipogenesis like can regulate autophagy. In this study, we examined using tsc2−/− mouse embryonic fibroblasts (MEFs) possessing constitutively...
Physapubescin B, a steroidal compound extracted from the plant Physalis pubescens L. (Solanaceae), has been reported to possess anti-cancer potential, whereas molecular mechanism remains elusive. In this study, we first demonstrated that physapubescin B induced autophagy in human cancer cells based on evidence increased lipidation of microtubule-associated protein 1 light chain 3 (LC3) as well number GFP-LC3 puncta. We further examined mechanisms and found enhanced autophagic flux through...
Macroautophagy/autophagy is a cellular process in which cytosolic contents are degraded by lysosome response to various stress conditions. Apart from its role the maintenance of homeostasis, autophagy also involves regulation cell cycle progression under nutrient-deprivation However, whether and how regulated especially during mitosis remains largely undefined. Here we show that WIPI2/ATG18B (WD repeat domain, phosphoinositide interacting 2), an autophagy-related (ATG) protein plays critical...