Hanwen Chen

ORCID: 0000-0002-4871-8789
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Research Areas
  • Cancer-related molecular mechanisms research
  • MicroRNA in disease regulation
  • Circular RNAs in diseases
  • Microplastics and Plastic Pollution
  • RNA modifications and cancer
  • Plasmonic and Surface Plasmon Research
  • Air Quality and Health Impacts
  • Inflammasome and immune disorders
  • Inflammatory Bowel Disease
  • Autophagy in Disease and Therapy
  • Sirtuins and Resveratrol in Medicine
  • Liver Disease Diagnosis and Treatment
  • Advanced Fiber Optic Sensors
  • Macrophage Migration Inhibitory Factor
  • Anesthesia and Neurotoxicity Research
  • Healthcare Systems and Reforms
  • Petroleum Processing and Analysis
  • IL-33, ST2, and ILC Pathways
  • Traditional Chinese Medicine Analysis
  • Target Tracking and Data Fusion in Sensor Networks
  • Nanoparticles: synthesis and applications
  • Evaluation and Optimization Models
  • Photonic and Optical Devices
  • Global Health Care Issues
  • Hydrocarbon exploration and reservoir analysis

Second Affiliated Hospital of Zhejiang University
2018-2025

Fudan University
2025

Zhejiang Chinese Medical University
2023-2025

The First People's Hospital of Shunde
2020-2024

Southern Medical University
2020-2024

Chinese Academy of Sciences
2023-2024

Nanjing Institute of Technology
2024

Hunan University
2024

Affiliated Hospital of Jining Medical University
2018-2024

Research Center for Eco-Environmental Sciences
2023-2024

Abstract Aims The aims of the study were to determine relationship between preoperative geriatric nutritional risk index (GNRI) and occurrence postoperative delirium (POD) in elderly patients after cardiac surgery evaluate additive value GNRI for predicting POD. Methods data extracted from Multiparameter Intelligent Monitoring Intensive Care (MIMIC‐IV) database. Patients who underwent aged 65 or older included. POD was investigated using logistic regression. We determined added predictive by...

10.1111/cns.14343 article EN cc-by CNS Neuroscience & Therapeutics 2023-07-05

Based on statistical data of the average abundance microplastics from 37 global freshwater locations up to November 2019, we classified bodies according developments in their local countries and geographic positions. We highlighted differences causes microplastic pollution waters both developed developing urban rural areas. The results showed that was highest Asia. significantly lower than countries. between areas mainly depended extent human activity. present study found following phenomena...

10.3390/w12071889 article EN Water 2020-07-02

The increasing incidence of inflammatory bowel disease (IBD) has imposed heavy financial burdens for Chinese patients; however, data about their status and access to health care are still lacking. This information is important informing patients with IBD treatment budgets strategies.The aim this study was evaluate the economic medical through China Crohn's & Colitis Foundation web-based platform in China.Our performed 14 centers mainland between 2018 2019 WeChat. Participants were asked...

10.2196/20629 article EN cc-by Journal of Medical Internet Research 2020-10-26

In this paper, we consider some Poisson-type equations arising from the study of electromagnetic wave propagation in metals and metamaterials, where sign-changing coefficients these lead to challenges that fall outside standard frameworks. We apply T-isomorphism method, expanding on approach [1], analyze fully asymmetric configurations. These configurations require a new construction isomorphism T. Finally, obtain well-posedness problems under certain parameters

10.54254/2753-8818/2025.20339 article EN cc-by Theoretical and Natural Science 2025-01-15

Cancer patients treated with current chemotherapeutic and targeted therapies frequently achieve partial remission, which ultimately relapse more aggressive, drug-resistant tumor phenotypes. To a certain extent, drug-tolerant persister (DTP) cells are responsible for residual tumors after systemic anticancer therapy the onset of acquired drug resistance. Therefore, novel targeting DTP to prevent resistance recurrence urgently needed. We aimed investigate traits key vulnerabilities ovarian...

10.1016/j.jare.2025.03.026 article EN cc-by-nc-nd Journal of Advanced Research 2025-03-01

Osteosarcoma is the most common primary bone sarcoma around world. The poor prognosis and high recurrence rate of osteosarcoma are largely due to pulmonary metastasis. H19 has been reported play a potential role in progression. However, exact molecular mechanism metastasis involving remains unclear. In present study, we performed gain- loss-of-function assays found that promotes migration invasion cells. Furthermore, showed through upregulation ZEB1 ZEB2 by competitively binding miR-200...

10.1089/dna.2015.3171 article EN DNA and Cell Biology 2016-03-23

ABSTRACT Myricetin, a natural flavonoid present in variety of fruits and vegetables, has been studied as promising cancer chemopreventive agent many models. It reported that myricetin could inhibit tumor promotion by inducing cell cycle arrest promoting apoptotic death. At present, autophagy is considered to be closely associated with cancer, functioning either an anti‐cancer or pro‐cancer mechanism depending on the stage. Till date, role regulating not reported. In this study, we found can...

10.1002/ar.23754 article EN The Anatomical Record 2017-12-16

Cypermethrin (CYM), a type II pyrethroid, is widely used as an insecticide for agriculture and household. Cumulative evidence indicates that acute chronic exposure to CYM might cause number of health problems, such cancer neuronal system diseases. However, the molecular mechanism underlying this pathology not known. The main objective study was define effects on macrophages implication in metastasis potential involved. were evaluated by detecting expression M1 M2 macrophage polarization...

10.1093/toxsci/kfy039 article EN Toxicological Sciences 2018-02-16

Cancer Susceptibility Candidate 15 (CASC15), which is a newly identified long noncoding RNA crucial for epigenetic regulation in human tumors, was found to be associated with poor prognosis of the patients ovarian cancer by utilizing The Genome Atlas and Gene Expression Omnibus database. Therefore, purpose this paper explore functional role latent molecular mechanism CASC15 progression cancer. In vitro vivo experiments validated as an oncogenic lncRNA cancer, could enhance metastasis through...

10.7150/ijbs.67486 article EN cc-by-nc International Journal of Biological Sciences 2022-01-01

Microplastics are emerging pollutants that threaten soil health and food safety. Recently, there has been increasing interest in understanding the behavior of these particles rhizosphere, specifically regarding potential uptake microplastics into crops. Arbuscular mycorrhizal (AM) fungi widespread fungi, forming symbiotic associations with most terrestrial plants. Therefore, it is essential to investigate if AM could protect crops from soil. Here, we grew vegetables (Lactuca sativa)...

10.1021/acs.jafc.3c05570 article EN Journal of Agricultural and Food Chemistry 2023-11-15

Introduction Observational studies have discovered a contradictory phenomenon between interleukin-17 (IL-17) and inflammatory bowel disease (IBD). The study aimed to confirm the causal association each subtype of IL-17 IBD. Methods We performed 2-sample univariable multivariable mendelian randomization (MR) determine which is causally related IBD its subtypes, used series sensitivity analysis examine reliability main MR assumptions. Results found that IL-17B, IL-17E IL-17RB were...

10.3389/fimmu.2023.1238457 article EN cc-by Frontiers in Immunology 2023-11-17

Propose To review published Physical Activity (PA) on the Mental Health of Children and Adolescents aged 5 to 18 years during COVID-19 pandemic-induced school closures. Methods From database creation April 2022, 10 databases are retrieved, with 4427 records filtered, 14 included in this research. The research takes Agency for Healthcare Research Quality (AHRQ) evaluation standards. Results thesis selects studies from 6 countries, involving 400009 children adolescents. These happened lockdown...

10.1371/journal.pone.0299158 article EN cc-by PLoS ONE 2024-06-25
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