A5040641714- Cancer Cells and Metastasis
- Clinical Laboratory Practices and Quality Control
- Advanced Glycation End Products research
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Sulfur Compounds in Biology
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Glutathione Transferases and Polymorphisms
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Redox biology and oxidative stress
- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cardiac Imaging and Diagnostics
- Metabolism, Diabetes, and Cancer
- Meta-analysis and systematic reviews
- RNA modifications and cancer
- Distributed Control Multi-Agent Systems
- Vitamin D Research Studies
The University of Texas MD Anderson Cancer Center
2016-2025
China Medical University
2025
Children's Hospital of Fudan University
2025
Qilu Hospital of Shandong University
2024
Henan Institute of Science and Technology
2024
Qinghai University
2023-2024
Central South University
2023-2024
Shenzhen Children's Hospital
2019-2023
Yunnan University of Traditional Chinese Medicine
2022
Columbia University Irving Medical Center
2021
Cystathionine γ-lyase (CSE) produces hydrogen sulfide (H2S) in the cardiovascular system. The deficiency of CSE mice leads to a decreased endogenous H2S level, an age-dependent increase blood pressure, and impaired endothelium-dependent vasorelaxation. To date, there is no direct evidence for causative role altered metabolism atherosclerosis development.Six-week-old gene knockout wild-type were fed with either control chow or atherogenic paigen-type diet 12 weeks. Plasma lipid profile...
Abstract Purpose: This study aimed to detect cell-surface vimentin (CSV) on the surface of epithelial–mesenchymal transitioned (EMT) circulating tumor cells (CTC) from blood patients with epithelial cancers. Experimental Design: In this study, 101 undergoing postsurgery adjuvant chemotherapy for metastatic colon cancer were recruited. EMT CTCs detected using 84-1 monoclonal antibody against CSV as a marker. isolated characterized further EMT-specific markers, fluorescent in situ...
Abstract Although circulating tumor cells (CTCs) have potential as diagnostic biomarkers for cancer, determining their prognostic role in cancer patients undergoing treatment is a challenge. We evaluated the value of programmed death-ligand 1 (PD-L1) expression CTCs colorectal and prostate treatment. Peripheral blood samples were collected from 62 metastatic 30 patients. isolated using magnetic separation with cell-surface vimentin(CSV)-specific 84-1 monoclonal antibody that detects...
Abstract BACKGROUND Detection, isolation, and enumeration of circulating tumor cells (CTCs) from cancer patients has become an important modality in clinical management with breast cancer. Although CellSearch, epithelial cell adhesion molecule (EpCAM)-based method that is used to isolate CTCs, gained prominence, its inability detect mesenchymal CTCs raises concerns regarding utility management. METHODS To address this gap technology, we recently discovered the cell-surface vimentin (CSV) as...
Liver function tests (LFTs) have been reported as independent predictors of non-liver disease-related morbidity and mortality in general population cancer patients. In this study, we evaluated the relationship between pretreatment serum LFTs overall survival (OS) non-metastatic Caucasian breast Seven LFTs, including albumin, alanine aminotransferase, aspartate alkaline phosphatase, lactate dehydrogenase (LDH), total bilirubin protein, were measured from 2425 female patients with newly...
Recent advances in the field of circulating tumor cells (CTC) have shown promise this liquid biopsy-based prognosis patient outcome. However, not all are cells, as evidenced by a lack tumor-specific markers. The current FDA standard for capturing CTCs (CellSearch) relies on an epithelial marker and captured via CellSearch cannot be considered to undergone EMT. Therefore, it is difficult ascertain presence relevance any mesenchymal or EMT-like CTCs. To address gap technology, we recently...
Abstract Antimicrobial resistance (AMR) is a pressing issue in China, with antibiotic therapy becoming less effective against bacterial infections. To address this challenge, the China Surveillance Network (CHINET) was established 2005 to monitor antimicrobial country. This study analyzed CHINET data from teaching hospitals and evaluated trends of AMR 2018 2022. A range 163,636 301,917 isolates obtained per year, majority being Gram-negative bacilli (69.0% 71.8%). The proportion important...
This study aimed to analyze the profiles and evolution of Staphylococcus aureus in pediatric intensive care units (PICUs) 17 hospitals China from 2016 2022. Susceptibility testing was performed bacterial strains with a uniform monitoring protocol, which provided by US Clinical Laboratory Standards Institute (CLSI) used Antimicrobial Surveillance Network (CHINET). The results were interpreted accordance performance standards for antimicrobial susceptibility issued Institute. Twenty-six...
Studies have shown that miR-221 and miR-222 are deregulated in many cancers, including prostate cancer. Nevertheless, the biological role underlying mechanisms of pathogenesis androgen-independent cancer still not clear. The proliferation, apoptosis, cell cycle distinction, migration capacity cells were determined following transfection or inhibitor. impact regulation SIRT1 on investigated. MiR-221 highly expressed PC-3 compared with LNCap cells. After expression was inhibited, proliferation...
Abstract Glutathione (GSH)/GSH reductase (GSR) and thioredoxin/thioredoxin (TXNRD) are two major compensating thiol-dependent antioxidant pathways that maintain protein dithiol/disulfide balance. We hypothesized functional deficiency in one of these systems would render cells dependent on compensation by the other system for survival, providing a mechanism-based synthetic lethality approach treatment cancers. The human GSR gene is located chromosome 8p12, region frequently lost deletion was...
Non-small cell lung cancer (NSCLC) accounts for approximately 85% of clinical cases. MicroRNA-93 (miR-93) is an oncomiR in many types human cancer, exerting pivotal effects the development and progression malignancies, including NSCLC. However, mechanism underlying miR-93 involvement NSCLC unknown. Our purpose was to reveal explain this mechanism, with goal contributing new diagnostic biomarkers individualized therapeutic tools.The expression determined lines A549, H1975, H1299. The cells...
Around the world, cervical cancer is fourth most common among women. MicroRNAs (miRNAs) and agents that target mRNAs have been introduced as novel diagnostic markers therapeutic approaches, respectively, in cancer. MiRNA-486-5p a candidate regulator of phosphatase tensin homolog (PTEN) silico, downregulation PTEN not consistent with its mutation, which suggests may be subjected to post-transcription modification moderated by miRNAs. Here, we aimed explore whether miR-486-5p development...
MicroRNA-21 (miR-21) is up-regulated in many cancers, including colorectal cancer (CRC). Nevertheless, the function of miR-21 CRC and mechanism underlying that still unclear. After analyzing expression Sec23A cell lines, we transfected highest expressing line, SW-480, with a plasmid containing an inhibitor lowest DLD-1, mimic measured effects on proliferation, migration, invasion. We also evaluated effect knocking down its Finally, assessed xenograft tumor model mice. Tumor tissues from...