A5032513924- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Telomeres, Telomerase, and Senescence
- Genetic factors in colorectal cancer
- Health, Environment, Cognitive Aging
- BRCA gene mutations in cancer
- Glutathione Transferases and Polymorphisms
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Nutrition, Genetics, and Disease
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- Head and Neck Cancer Studies
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Smoking Behavior and Cessation
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Obesity, Physical Activity, Diet
Zhejiang University
2020-2025
George Washington University
2024-2025
Zhejiang Cancer Hospital
2024-2025
Second Affiliated Hospital of Zhejiang University
2024-2025
Qiqihar Medical University
2025
Zhejiang Chinese Medical University
2024
Zhejiang Medicine (China)
2024
Chinese Academy of Sciences
2024
Universidad Católica de Santa Fe
2024
The University of Texas MD Anderson Cancer Center
2013-2022
On January 20, 2020, a new coronavirus epidemic with human-to-human transmission was officially declared by the Chinese government, which caused significant public panic in China. In light of disease 2019 outbreak, pregnant women may be particularly vulnerable and special need for preventive mental health strategies. Thus far, no reports exist to investigate response outbreak.This study aimed examine impact outbreak on prevalence depressive anxiety symptoms corresponding risk factors among...
Background: Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the association between length and cancer risk four ongoing case–control studies. Methods: All studies had equal numbers of case patients matched control subjects (92 for head neck cancer, 135 bladder 54 lung 32 renal cell carcinoma). Telomere was measured peripheral blood lymphocytes from study participants. assessed comet assay. Patient disease...
BackgroundReliable risk prediction tools for estimating individual probability of lung cancer have important public health implications. We constructed and validated a comprehensive clinical tool by smoking status.
Epigenetic dysregulation has emerged as a major contributor to tumorigenesis. Histone methylation is well-established mechanism of epigenetic regulation that dynamically modulated by histone methyltransferases and demethylases. The pathogenic role modifiers in non-small cell lung cancer (NSCLC), which the leading cause deaths worldwide, remains largely unknown. Here, we found H3 lysine 36 (H3K36) demethylase KDM2A (also called FBXL11 JHDM1A) frequently overexpressed NSCLC tumors lines. its...
Liver function tests (LFTs) have been reported as independent predictors of non-liver disease-related morbidity and mortality in general population cancer patients. In this study, we evaluated the relationship between pretreatment serum LFTs overall survival (OS) non-metastatic Caucasian breast Seven LFTs, including albumin, alanine aminotransferase, aspartate alkaline phosphatase, lactate dehydrogenase (LDH), total bilirubin protein, were measured from 2425 female patients with newly...
BackgroundRisk prediction models for hepatocellular carcinoma are available individuals with chronic hepatitis B virus (HBV) and C (HCV) infections who at high risk but not the general population average or unknown risk. We developed five simple based on clinically data from population.
Abstract Platinum nanoparticles (PtNPs) efficiently catalyze the transformation of H 2 O into oxygen gas. However, owing to lack an efficient approach or device that can measure produced gas, catalytic reaction has never been used for diagnostic applications. Microfluidics technology provides a platform meets these requirements. The volumetric bar‐chart chip (V‐Chip) volumetrically measures production gas by PtNPs and be integrated with ELISA provide visible quantitative readouts without...
Multiple myeloma (MM) is the second most common haematologic malignancy, presenting a great disease burden on general population; however, quality of care MM overlooked. We therefore assessed gains and disparity in worldwide from 1990 to 2019 based novel summary indicator - index (QCI) examined its potential for improvement.
We took a polygenic approach to evaluate the effects of 41 potentially functional single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs)-related genes on survival and recurrence among renal cell carcinoma (RCC) patients. During median follow-up 21.8 months, 316 RCC patients, 64 died 56 developed recurrence. In single-SNP analysis, we identified seven SNPs significantly associated with five The most significant associations were GEMIN4 variant alleles both rs7813 rs910925 1.74-fold [95%...
The clinical predictors and biological mechanisms for localized prostate cancer (PCa) outcomes remain mostly unknown. We aim to evaluate the role of serum immune-checkpoint-related (ICK) proteins genetic variations in predicting PCa.
Abstract Background Chronic obstructive pulmonary disease (COPD) is a frequently diagnosed yet treatable condition, provided it identified early and managed effectively. This study aims to develop an advanced COPD diagnostic model by integrating deep learning radiomics features. Methods We utilized dataset comprising CT images from 2,983 participants, of which 2,317 participants also epidemiological data through questionnaires. Deep features were extracted using Variational Autoencoder,...
In order to solve the problem of high probability information loss in traditional sports training management systems, authors propose design an athlete process monitoring and feedback system based on mobile intelligent devices. The improves storage servers, collection sub sites, processors terms hardware, processes users' real-time. software design, classify different users, calculate similarity complete management. experimental results show that for average packet rate tablet device users...
Biological age is an important measure of aging that reflects individual's physical health and linked to various diseases. Current prediction models are still limited in precision, the risk factors for accelerated remain underexplored. Therefore, we aimed develop a precise biological assess impact socio-demographic behavioral patterns on process.We utilized Deep Neural Networks (DNN) construct from participants with examinations, blood samples, questionnaires data China Kadoorie Biobank...
Lung cancer is a malignant tumor with high morbidity and mortality rate worldwide, causing an increasing disease burden. Of these, the most common type non-small cell lung (NSCLC), which accounts for 80-85% of all cases. Genetic research crucial continuously discovering susceptibility genes related to in-depth study. The role genetic predisposition in development NSCLC, particularly within circadian rhythm pathways known govern various physiological processes, increasingly acknowledged. Yet,...
The aim of this study was to screen three major substance metabolism-related genes and establish a prognostic model for osteosarcoma. RNA-seq expression data osteosarcoma were downloaded from Cancer Genome Atlas (TCGA) GEO databases. Differentially expressed (DE) RNAs selected, followed by the selection metabolic-related DE mRNAs. Using Cox regression analysis, identified construct model. Subsequently, independent clinical factors screened, functions long non-coding (lncRNAs) analyzed....