A5086212361- Renal cell carcinoma treatment
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Cancer survivorship and care
- CAR-T cell therapy research
- Renal and related cancers
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Proteomics Techniques and Applications
- Palliative Care and End-of-Life Issues
- Economic and Financial Impacts of Cancer
- Global Cancer Incidence and Screening
- Bladder and Urothelial Cancer Treatments
- Childhood Cancer Survivors' Quality of Life
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- Patient-Provider Communication in Healthcare
- Viral gastroenteritis research and epidemiology
- Advances in Oncology and Radiotherapy
- Mass Spectrometry Techniques and Applications
- Molecular Biology Techniques and Applications
- Ovarian cancer diagnosis and treatment
- Lymphoma Diagnosis and Treatment
University of Leeds
2016-2025
University of Lincoln
2021-2025
University of Toronto
2024-2025
Centre for Addiction and Mental Health
2023-2025
British Columbia Centre on Substance Use
2025
Waypoint Centre for Mental Health Care
2025
Université de Montréal
2025
University of British Columbia
2025
St James's University Hospital
2015-2024
Dolby (Netherlands)
2024
High-dose therapy with supporting autologous stem-cell transplantation remains a controversial treatment for cancer. In multiple myeloma, first-line regimens incorporating high-dose yield higher remission rates than do conventional-dose treatments, but evidence that this translates into improved survival is limited.
To examine the effects on process of care and patient well-being, regular collection use health-related quality-of-life (HRQL) data in oncology practice.In a prospective study with repeated measures involving 28 oncologists, 286 cancer patients were randomly assigned to either intervention group (regular completion European Organization for Research Treatment Cancer-Core Quality Life Questionnaire version 3.0, Hospital Anxiety Depression Scale touch-screen computers clinic feedback results...
PURPOSE: We aimed to estimate the prevalence and types of anxiety disorders diagnosed according standardized criteria in cancer patients, compare screening tools detecting them, examine their demographic, oncologic, psychosocial associations. METHODS: In this cross-sectional observational study 178 subjects with lymphoma, renal cell carcinoma, malignant melanoma, or plasma dyscrasia, we related responses questionnaires (administered by computer touch-screen) measuring psychological symptoms,...
Despite recent developments in bottom-up proteomics, the need still exists a fast, uncomplicated, and robust method for comprehensive sample processing especially when applied to low protein amounts. The suspension trapping combines advantage of efficient SDS-based extraction with rapid detergent removal, reactor-type digestion, peptide cleanup. Proteins are solubilized SDS. is acidified introduced into tip incorporating depth filter hydrophobic compartments, filled neutral pH methanolic...
Intravenous infusion of oncolytic reovirus in patients leads to infection brain tumors, infiltration by cytotoxic T cells, and up-regulation PD-L1.
To evaluate our clinical experience with percutaneous image-guided radiofrequency ablation (RFA) of 200 renal tumours in a large tertiary referral university institution.Image-guided RFA (ultrasonography or computed tomography [CT]) 165 patients from June 2004 to 2012 was prospectively evaluated. Institutional Review Board approval granted. The treatment response and technical success were defined by absence contrast enhancement within the tumour on enhanced CT magnetic resonance imaging....
To evaluate alternative automated methods of collecting data on quality life (QOL) in cancer patients. After initial evaluation a range technologies, we compared computer touch-screen questionnaires with paper scanned by optical reading systems terms patients' acceptance, quality, and reliability.In randomized cross-over trial, 149 patients completed the European Organization for Research Treatment Cancer Quality Life Questionnaire-Core 30, version 2.0 (EORTC QLQ-C30), Hospital Anxiety...
Exosomes are 40-100 nm vesicles released by numerous cell types and thought to have a variety of roles depending on their origin. derived from antigen presenting cells been shown be capable initiating immune responses in vivo eradicating established tumours murine models. Tumour-derived exosomes can utilised as source tumour for cross-priming T-cells thus interest use anti-tumour immunotherapy. Further exploration into the protein composition may increase our understanding potential this...
Genetic and epigenetic changes in the von Hippel-Lindau (VHL) tumor suppressor gene are common sporadic conventional renal cell carcinoma (cRCC). Further insight into clinical significance of these may lead to increased biological understanding identification subgroups patients differing prognostically or who benefit from specific targeted treatments. We have comprehensively examined VHL status tissue samples 115 undergoing nephrectomy, including 96 with cRCC. In cRCC, loss heterozygosity...
High dose melphalan (HDM, 140 mg/m2 i.v.) has been evaluated in 58 patients under 63 years with multiple myeloma. Among previously untreated 11/41 (27%) entered a complete remission (CR: no measurable myeloma protein and normal bone marrow) 21 (51%) partial (more than 50% reduction improvement all other features). Median duration of is 19 months. Two who had responded to previous conventional treatment CR after HDM. 15 failed on chemotherapy the response rate was 66% including two CRs....
A primary objective of many protein expression studies is to define patterns that can distinguish between normal and diseased states, enabling a better understanding molecular events associated with disease development progression ultimately potentially finding novel markers or therapeutic targets. Exploration confirmation proteins often done using Western blotting normalization against “housekeeping proteins”, such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH), β-actin, β-tubulin,...
Abstract Renal cell carcinoma (RCC) is the tenth most common cancer although incidence increasing. The main clinical problems stem from relatively late presentation of many patients due to often asymptomatic nature illness, and relative insensitivity metastatic disease conventional chemotherapy radiotherapy. Despite increasing knowledge some genetic changes underlying sporadic renal such as those involving Von Hippel Lindau (VHL) gene, pathophysiological are ill‐defined there remains a need...
Profiling approaches in proteomics, such as surface-enhanced laser desorption/ionization (SELDI) mass spectrometry, are used disease marker discovery. The aim of this study was to investigate the potential influence selected preanalytical factors on results obtained.Plasma samples anticoagulated with EDTA, citrate, or heparin, and serum from healthy volunteers were profiled by SELDI CM10, immobilized metal affinity capture (IMAC) array copper, H50 chip surfaces. Using linear mixed-effects...
PURPOSE We report the results of intensive chemotherapy with high-dose melphalan (HDM) following conventional-dose cytoreductive in previously untreated patients myeloma. PATIENTS AND METHODS From 1986 to 1991, 53 myeloma received HDM 200 mg/m2 plus methylprednisolone 1.5 g daily (MP) for 5 days autologous bone marrow transplantation (ABMT) after chemotherapy. RESULTS At time administration, responses induction therapy were complete remission (CR) nine patients, partial (PR) 38, and no...