A5086581375- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Cancer, Lipids, and Metabolism
- Protein Degradation and Inhibitors
- Platelet Disorders and Treatments
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Ocular Surface and Contact Lens
- Hemoglobinopathies and Related Disorders
- Ophthalmology and Visual Impairment Studies
- RNA modifications and cancer
- Air Quality and Health Impacts
- Cancer therapeutics and mechanisms
- Corneal surgery and disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Melanoma and MAPK Pathways
- Cancer Mechanisms and Therapy
- Nanoparticle-Based Drug Delivery
- Nuclear Structure and Function
- Inflammatory Biomarkers in Disease Prognosis
- PARP inhibition in cancer therapy
First Affiliated Hospital Zhejiang University
2020-2025
Fujian Medical University
2024-2025
Zhejiang University
2020-2024
Hangzhou Cancer Hospital
2024
Zhejiang Cancer Hospital
2021-2024
Blood Center of Zhejiang Province
2020
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020
Wenzhou Medical University
2020
Zhongnan Hospital of Wuhan University
2018
Wuhan University
2018
Chronic lymphocytic leukemia (CLL) is the most prevalent subtype of in Western countries, causing a substantial health burden on patients and society. Comprehensive evaluation epidemiological characteristics CLL warranted, especially current context global population aging. The main objective this study evaluating disease at global, regional, national levels from 1990 to 2019. As secondary objectives, we studied influence demographic factors performed risk factor analysis. We hope could...
The current classification of acute myeloid leukemia (AML) relies largely on genomic alterations. Robust identification clinically and biologically relevant molecular subtypes from nongenomic high-throughput sequencing data remains challenging. We established the largest multicenter AML cohort (n = 655) in China, with all patients subjected to RNA (RNA-Seq) 619 (94.5%) targeted or whole-exome (TES/WES). Based an enhanced consensus clustering, eight stable gene expression subgroups (G1–G8)...
Multiple myeloma (MM) is the second most common haematologic malignancy, presenting a great disease burden on general population; however, quality of care MM overlooked. We therefore assessed gains and disparity in worldwide from 1990 to 2019 based novel summary indicator - index (QCI) examined its potential for improvement.
Abstract Background Acute myeloid leukaemia (AML) is a haematological malignancy with unfavourable prognosis. Despite the effectiveness of chemotherapy and targeted therapy, relapse or drug resistance remains major threat to AML patients. N6‐methyladenosine (m 6 A) RNA methylation super‐enhancers (SEs) are extensively involved in leukaemogenesis AML. However, potential relationship between m A SEs has not been elaborated. Methods Chromatin immunoprecipitation (ChIP) sequencing data from Gene...
Cytoskeletal remodeling and mitochondrial bioenergetics play important roles in thrombocytopoiesis platelet function. Recently, α-actinin-1 mutations have been reported patients with congenital macrothrombocytopenia. However, the role underlying mechanism of function remain elusive. Using MK-specific knockout (PF4-Actn1-/-) mice, we demonstrated that PF4-Actn1-/- mice exhibited reduced counts. The decreased number was due to defects thrombocytopoiesis. H&E staining flow cytometry...
Acute myeloid leukemia (AML) is an aging-related and heterogeneous hematopoietic malignancy. In this study, a total of 1,474 newly diagnosed AML patients with RNA sequencing data were enrolled, targeted or whole exome obtained in 94% cases. The correlation factors including age clonal hematopoiesis (CH), gender, genomic/transcriptomic profiles (gene fusions, genetic mutations, gene expression networks pathways) was systematically analyzed. Overall, aged 60 y older showed apparently dismal...
To investigate the changes in meibomian gland (MG) structure allergic conjunctivitis (AC) patients using an intelligent quantitative analysis algorithm and to explore relationship between these clinical parameters. A total of 252 eyes from with AC 200 normal controls were examined. Infrared meibography was performed non-contact mode Keratograph 5M. MG images analyzed a deep learning-based evaluate length, area, dropout ratio, deformation. Clinical parameters, including tear meniscus height,...
Acute myeloid leukemia (AML) is an aggressive and often deadly malignancy associated with proliferative immature blasts. Here, we identified CD84 as a critical survival regulator in AML. High levels of expression provided advantage to cells, whereas downregulation disrupted their proliferation, clonogenicity engraftment capabilities both human cell lines patient derived xenograft cells. Critically, loss also markedly blocked MLL-AF9 inv(16) AML mouse models, highlighting its pivotal role...
Abstract Background Fatty acid oxidation (FAO) provides an important source of energy to promote the growth leukemia cells. Carnitine palmitoyltransferase 1a(CPT1a), a rate-limiting enzyme essential step FAO, can facilitate cancer metabolic adaptation. Previous reports demonstrated that CPT1a acts as potential molecular target in solid tumors and hematologic disease. However, no systematic study was conducted explore prognostic value expression possible treatment strategies with inhibitor on...
Abstract Background Spermatogenesis associated serine rich 2 like (SPATS2L) was highly expressed in homoharringtonine (HHT) resistant acute myeloid leukemia (AML) cell lines. However, its role is little known AML. The present study aimed to investigate the function of SPATS2L AML pathogenesis and elucidate underlying molecular mechanisms. Methods Overall survival (OS), event-free (EFS), relapse-free (RFS) were used evaluate prognostic impact for from TCGA database ourcohort. ShRNA knockdown...
Summary Glutamine metabolic reprogramming in acute myeloid leukaemia (AML) cells contributes to the decreased sensitivity antileukemic drugs. Leukaemic cells, but not their counterparts, largely depend on glutamine. Glutamate dehydrogenase 1 (GDH1) is a regulation enzyme glutaminolysis. However, its role AML remains unknown. Here, we reported that GDH1 was highly expressed AML: high one of independent negative prognostic factors cohort. The dependence leukaemic proved both vitro and vivo....
Despite advances in targeted agent development, effective treatment of acute myeloid leukemia (AML) remains a major clinical challenge. The B-cell lymphoma-2 (BCL-2) inhibitor exhibited promising activity AML, lymphoblastic (ALL) and diffuse large lymphoma (DLBCL) treatment. APG-2575 is novel BCL-2 selective inhibitor, which has demonstrated anti-tumor hematologic malignancies. Homoharringtonine (HHT), an alkaloid, anti-AML activity.The synergistic effects HHT were studied AML cell lines...
Abstract Background Identifying therapeutic targets and prognostic biomarkers significantly contributes to individualized treatment of acute myeloid leukemia (AML). Dihydropyrimidinase‐like 2 (DPYSL2) expression was decreased in homoharringtonine (HHT)‐resistant AML cells, which were established by our group. DPYSL2 plays an important role axon growth has oncogene effect glioblastoma. However, little research been conducted investigate the function pathogenesis. Methods Auto‐docking used...
Purpose To develop a predictive model for orthokeratology (Ortho-K) lens decentration 1 month after wear. Methods This study included myopic children who were fitted with Ortho-K lenses at Fujian Provincial Hospital between December 2022 and May 2024. Corneal topography parameters other relevant metrics collected pre- post-treatment. Feature selection was conducted using univariate logistic regression Lasso analysis. A machine learning approach used to multiple models, including Decision...
Aim: We investigated a promising cooperative combination of radiotherapy (RT) and programmed death ligand 1 (PD-L1) monoclonal antibodies (mAb) in both local abscopal tumors. Materials & methods: C57BL/6 mice were randomly grouped received RT, α-PD-L1 mAb or therapy 13 days after implantation Lewis lung carcinoma cells. Flow cytometry immunohistochemistry analyses demonstrated CD8+ T-cell infiltration PD-L1 expression tumor issue. Cytometric bead arrays used to examine cytokine levels....
BACKGROUND: Fatty acid oxidation has been considered as an important energy source for tumorigenesis and development. Several studies have investigated the role of CPT1A, a kind fatty rate-limiting enzyme, in AML. However, prognostic value regulatory network another subtype, CPT1B AML remains elusive. This study aims to clarify independent CN-AML based on clinical data molecular level (mRNA, miRNA lncRNA). OBJECTIVE: The aim this is investigate patients. METHODS: First, we analyzed...
Circular RNAs (circRNAs), a type of endogenous noncoding RNA (ncRNA), exert vital roles in leukemia progression and are promising prognostic factors. Here, we report novel circRNA, circSLC25A13 (hsa_circ_0081188), which was increased acute myeloid (AML) patients with poor overall survival (OS) comparing to good prognosis. Knockdown AML cells inhibited proliferation cell apoptosis vitro vivo. Enhanced expression promoted the cells. Mechanistically, played as microRNA sponge miR-616-3p,...