A5025121085- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Glioma Diagnosis and Treatment
- Blood properties and coagulation
- Paraquat toxicity studies and treatments
- Peripheral Neuropathies and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Hereditary Neurological Disorders
- Ferroptosis and cancer prognosis
- Biochemical and Structural Characterization
- Parkinson's Disease Mechanisms and Treatments
- Meningioma and schwannoma management
- Inflammation biomarkers and pathways
- Liver Disease and Transplantation
- Aortic aneurysm repair treatments
- Blood disorders and treatments
- Transplantation: Methods and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Lymphoma Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Autoimmune Bullous Skin Diseases
Second Affiliated Hospital of Nanjing Medical University
2020-2025
Chongqing Medical University
2021-2024
Tianjin Medical University
2009-2024
Tianjin First Center Hospital
2009-2024
Nanjing Agricultural University
2024
Dalian Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Shanghai Ninth People's Hospital
2024
Ruijin Hospital
2013-2023
Shanghai Jiao Tong University
2013-2023
Cytoskeletal remodeling and mitochondrial bioenergetics play important roles in thrombocytopoiesis platelet function. Recently, α-actinin-1 mutations have been reported patients with congenital macrothrombocytopenia. However, the role underlying mechanism of function remain elusive. Using MK-specific knockout (PF4-Actn1-/-) mice, we demonstrated that PF4-Actn1-/- mice exhibited reduced counts. The decreased number was due to defects thrombocytopoiesis. H&E staining flow cytometry...
Abstract Chronic hepatitis B virus (HBV) infection is a significant public health burden worldwide. HBV covalently closed circular DNA (cccDNA) organized as minichromosome in nucleus responsible for viral persistence and the key obstacle cure of chronic (CHB). Recent studies suggest cccDNA transcription epigenetically regulated by histone modifications, especially acetylation methylation. In present study, we identified transcriptionally active succinylation (H3K122succ) new modification on...
Abstract Background Catheter-associated urinary tract infection (CAUTI) is a common nosocomial device-associated infection. It now recognized that the high rates were caused by formation of biofilm on surface catheters decreases susceptibility to antibiotics and results in anti-microbial resistance. In this study, we performed an vitro test explore mechanism subsequently conducted multi-center clinical trial investigate efficacy CAUTI prevention with application JUC, nanotechnology...
Thrombosis and hemostasis take place in flowing blood, which generates shear forces. The effect of different rates, particularly pathological forces, on platelet thrombus formation remains to be fully elucidated. present study observed the morphological characteristics hierarchical structure thrombi collagen surface at a wide range wall rates (WSRs) examined underlying mechanisms. Calcein AM‑labeled whole blood was perfused over collagen‑coated set by Bioflux 200 microfluidic device formed...
Background POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M protein, and Skin changes) syndrome is a complicated rare disease. Systematic research on computed tomography (CT) imaging characteristics in scanty. The role of CT diagnosis needs to be assessed. Purpose To retrospectively analyze the features 24 patients with evaluate this Material Methods Twenty-four confirmed were included study. Chest abdominal images analyzed. Results three minor diagnostic criteria for (extravascular...
Abstract Paraquat (PQ) is a widely used and highly toxic pesticide that often actively ingested causes pulmonary fibrosis in patients. Ferroptosis regulated form of non-apoptotic cell death associated with iron-dependent lipid peroxidation. Previous studies have shown ferroptosis involved the occurrence development acute lung injury (ALI). In this study, model rat inflammatory response, oxidative stress, peroxidation, was successfully established by PQ administration. The rats confirmed...
Glial cell line-derived neurotrophic factor (GDNF) is a heparan sulfate (HS)-binding factor. GDNF produced by somatic Sertoli cells, where it signals to maintain spermatogonial stem cells (SSCs) and reproduction. Here, we investigate the roles of extracellular HS 6-O-endosulfatases (Sulfs), Sulf1 Sulf2, in matrix transmission from SSCs. Although Sulfs are not required for testis formation, Sulf deficiency leads accelerated depletion SSCs, phenotype similar that GDNF+/− mice. Mechanistically,...
Abstract Parkinson disease (PD) is a chronic progressive neurodegenerative disorder characterized pathologically by early loss of neuromelanin (NM) in the substantia nigra pars compacta (SNpc) and increased iron deposition (SN). Degeneration SN presents as 50 to 70% pigmented neurons ventral lateral tier SNpc at onset symptoms. Also, using magnetic resonance imaging (MRI), volume changes red nucleus (RN), subthalamic (STN) have been reported be associated with status rate progression....
Early diagnosis of Parkinson's disease (PD) is still a clinical challenge. Most previous studies using manual or semi-automated methods for segmenting the substantia nigra (SN) are time-consuming and, despite raters being well-trained, individual variation can be significant. In this study, we used template-based, automatic, SN subregion segmentation pipeline to detect neuromelanin (NM) and iron features in pars compacta (SNpc) derived from single 3D magnetization transfer contrast (MTC)...
Tanshinol is an active constituent of Salvia miltiorrhiza that possesses anti-inflammatory, antioxidant, and antibacterial activities. Therefore, this study attempted to detect whether it has a role in the treatment preeclampsia (PE).In study, we explored effect tanshinol on development PE at cellular level. The cell proliferation was measured by colony formation EdU assays. migration, invasion, vitro angiogenesis HTR-8/SVneo cells were detected wound-healing, transwell, tube assays,...
Interaction of integrin β3 with c-Src plays critical roles in cellular signaling which is heavily implicated platelet adhesion and aggregation, as well tumor cell proliferation metastasis or osteoclastic bone resorption. Selectively blocking αIIbβ3 outside-in platelets has been a focus attention because its effective antithrombotic potential together sufficient hemostatic capacity. The myristoylated RGT peptide shown to achieve this blockade by targeting the association tail, but lack key...
BackgroundPOEMS syndrome, a rare paraneoplastic disease, is related to multiple organs, systems, and disciplines can be mistaken for other disorders. Consequently, the diagnoses are often delayed. In this work we studied clinicopathologic characteristics of POEMS syndrome improve early diagnosis prevent irreversible damage.Patients MethodsWe conducted analysis 9 cases made differential with diseases.ResultsThe patients were shown have complicated clinical characteristics, including...