A5007800714- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Protein Structure and Dynamics
- Advanced MRI Techniques and Applications
- RNA regulation and disease
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- Neurological disorders and treatments
- Bacteriophages and microbial interactions
- Management and Optimization Techniques
- Process Optimization and Integration
- Atomic and Subatomic Physics Research
- Scheduling and Optimization Algorithms
Magnetic Resonance Innovations (United States)
2020-2022
Wayne State University
2017-2018
Amirkabir University of Technology
2017
Diagnosing early stage Parkinson's disease (PD) is still a clinical challenge. Previous studies using iron, neuromelanin (NM) or the Nigrosome-1 (N1) sign in substantia nigra (SN) by themselves have been unable to provide sufficiently high diagnostic performance for these methods be adopted clinically. Our goal this study was extract NM complex volume, iron content and volume representing entire SN, N1 as potential complementary imaging biomarkers single 3D magnetization transfer contrast...
Abstract Parkinson disease (PD) is a chronic progressive neurodegenerative disorder characterized pathologically by early loss of neuromelanin (NM) in the substantia nigra pars compacta (SNpc) and increased iron deposition (SN). Degeneration SN presents as 50 to 70% pigmented neurons ventral lateral tier SNpc at onset symptoms. Also, using magnetic resonance imaging (MRI), volume changes red nucleus (RN), subthalamic (STN) have been reported be associated with status rate progression....
Early diagnosis of Parkinson's disease (PD) is still a clinical challenge. Most previous studies using manual or semi-automated methods for segmenting the substantia nigra (SN) are time-consuming and, despite raters being well-trained, individual variation can be significant. In this study, we used template-based, automatic, SN subregion segmentation pipeline to detect neuromelanin (NM) and iron features in pars compacta (SNpc) derived from single 3D magnetization transfer contrast (MTC)...
Purpose: To develop a method to reconstruct quantitative susceptibility mapping (QSM) from multi-echo, multi-flip angle data collected using strategically acquired gradient echo (STAGE) imaging. Methods: The proposed QSM reconstruction algorithm, referred as "structurally constrained Susceptibility Weighted Imaging and Mapping" scSWIM, performs an l_1 l_2 regularization-based in single step. unique contrast of the T1 weighted enhanced (T1WE) image derived STAGE imaging was used extract...
<p><em>Manufacturing speed is one of the most important factors in pharmaceutical production, since drug excipient sensitive and its exposure to light temperature should be controlled. Therefore, by minimizing manufacturing cycle time, quality product can improved. This process also results cost such as working hours, human resource, energy consumption overhead while increasing system productivity. In this study, using a stochastic dynamic programming method, time plant with...
A total of 100 Parkinson&rsquo;s disease (PD) patients and age- sex-matched healthy controls (HCs) were scanned using a single 3D gradient echo magnetization transfer sequence. We developed an automatic substantia nigra (SN) subregions segmentation approach to get neuromelanin (NM) iron measurements in the SN. These measures along with their overlap region volume nigrosome-1 (N1) sign showed reliable results indicative promising diagnostic biomarkers differentiate PD from HCs.