A5012391798- Catalytic Processes in Materials Science
- Drug Transport and Resistance Mechanisms
- Catalysis and Oxidation Reactions
- Prenatal Screening and Diagnostics
- Genomic variations and chromosomal abnormalities
- Pharmacological Effects and Toxicity Studies
- CRISPR and Genetic Engineering
- Microbial Metabolic Engineering and Bioproduction
- Pharmacogenetics and Drug Metabolism
- Catalysts for Methane Reforming
- Plasma Applications and Diagnostics
- Plant Pathogens and Fungal Diseases
- Graphene research and applications
- Analytical Chemistry and Chromatography
- Advanced Photocatalysis Techniques
- Viral gastroenteritis research and epidemiology
- Metabolism and Genetic Disorders
- Metal-Organic Frameworks: Synthesis and Applications
- Inflammasome and immune disorders
- Genetic Syndromes and Imprinting
- Zeolite Catalysis and Synthesis
- Software Engineering and Design Patterns
- Phytochemical Studies and Bioactivities
- Drug-Induced Hepatotoxicity and Protection
- Animal Disease Management and Epidemiology
China Agricultural University
2021-2025
Bristol-Myers Squibb (United States)
2011-2024
Obstetrics and Gynecology Hospital of Fudan University
2006-2024
Renji Hospital
2024
Shanghai Jiao Tong University
2024
Cixian People's Hospital
2024
Peking Union Medical College Hospital
2024
Mayo Clinic
2024
WinnMed
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Sex chromosomes evolved from autosomes many times across the eukaryote phylogeny. Several models have been proposed to explain this transition, some involving male and female sterility mutations linked in a region of suppressed recombination between X Y (or Z/W, U/V) chromosomes. Comparative experimental analysis reference genome assembly for double haploid YY garden asparagus (Asparagus officinalis L.) individual implicates separate but genes as responsible sex determination. Dioecy has...
Substituted N-(4-(2-aminopyridin-4-yloxy)-3-fluoro-phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamides were identified as potent and selective Met kinase inhibitors. Substitution of the pyridine 3-position gave improved enzyme potency, while substitution pyridone 4-position led to aqueous solubility selectivity. Analogue 10 demonstrated complete tumor stasis in a Met-dependent GTL-16 human gastric carcinoma xenograft model following oral administration. Because its excellent...
An overview of important recent advances on synthesis, characterization and application defective metal–organic frameworks is provided.
Abstract With rapid progress in DNA synthesis and sequencing, strain engineering starts to be the rate-limiting step synthetic biology. Here, we report a gRNA-tRNA array for CRISPR-Cas9 (GTR-CRISPR) multiplexed of Saccharomyces cerevisiae . Using reported gRNAs shown effective, this system enables simultaneous disruption 8 genes with 87% efficiency. We further an accelerated Lightning GTR-CRISPR that avoids cloning Escherichia coli by directly transforming Golden Gate reaction mix yeast....
Full-bandwidth connectivity between all servers of a data center may be necessary for all-to-all traffic patterns, but such interconnects suffer from high cost, complexity, and energy consumption. Recent work has argued that if is uncommon, oversubscribed network architectures can adapt the topology to meet demands, are sufficient. In line with this work, we propose Proteus, an all-optical architecture targeting unprecedented topology-flexibility, lower complexity higher efficiency.
Although many prokaryotes have glycolysis alternatives, it's considered as the only energy-generating glucose catabolic pathway in eukaryotes. Here, we managed to create a hybrid-glycolysis yeast. Subsequently, identified an inositol pyrophosphatase encoded by OCA5 that could regulate and respiration adjusting 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate (5-InsP7) levels. 5-InsP7 levels expression of genes involved respiration, representing global mechanism sense ATP central carbon...
We recently showed that riboflavin is a selected substrate of BCRP over P-gp and demonstrated its prediction performance in preclinical DDI studies. The aim this study was to investigate the suitability assess inhibition humans. First, we assessed potential towards other major drug transporters using established transfected cell systems. Riboflavin for OAT1, OAT3, MATE2-K with uptake ratios ranging from 2.69 11.6 but not OATP1B1, OATP1B3, OCT2, MATE1. effects BMS-986371, potent vitro...
A novel plasma reduction method has been developed to reduce supported noble-metal ions without the use of any reducing chemicals. H2PtCl6, PdCl2, AgNO3, and HAuCl4 on nonporous TiO2 porous γ-Al2O3 HZSM-5 were reduced using an Ar glow discharge plasma. Optical absorption spectra X-ray photoelectron spectroscopy show that metal are completely metallic species. Transmission electron microscopy shows prepared metals amorphous clusters homogeneously distributed with nanoscale sizes. diffraction...
NiO-loaded semiconductors have been extensively used as the photocatalysts for water splitting. The metal−support interface is an important factor affecting efficiency. In present work, pretreatment methods were studied to produce a more desirable using Ta2O5 and ZrO2 support. traditional method includes thermal decomposition, reduction at 773 K, oxidation 473 K (R773−O473). decomposition of Ni(NO3)2 makes Ni atoms migrate into bulk supports, resulting in diffused interfacial region....
Conformationally constrained 2-pyridone analogue 2 is a potent Met kinase inhibitor with an IC50 value of 1.8 nM. Further SAR the based inhibitors led to 4-pyridone and pyridine N-oxide such as 3 4. The X-ray crystallographic data bound ATP binding site protein provided insight into modes these inhibitors, this series analogues was rationalized. Many showed antiproliferative activities against dependent GTL-16 gastric carcinoma cell line. Compound also inhibited Flt-3 VEGFR-2 kinases values...
The contribution of organic anion transporter OAT2 (SLC22A7) to the renal tubular secretion creatinine and its exact localization in kidney are reportedly controversial. In present investigation, transport was assessed human embryonic (HEK) cells that stably expressed (OAT2-HEK) isolated proximal tubule (HRPTCs). human, monkey, rat characterized. overexpression significantly enhanced uptake OAT2-HEK cells. Under physiologic conditions (creatinine concentrations 41.2 123.5 <i>µ</i>M), initial...
Manure amendment generally bolsters soil organisms but not all bacteria equally. To understand why different taxa respond differently, we used shotgun metagenomic approaches to profile functional potentials and correlate them with taxon abundances. A originally unproductive was reclaimed using commercial manure finally became productive. The abundance of Firmicutes in the decreased, whereas that Bacteroidetes Proteobacteria increased after addition. Thirty-nine KEGG modules were...
We prepared a new rare-earth compound, Eu9MgS2B20O41 (EMSBO), and characterized its structural physical properties. EMSBO consists of triple-Kagomé-layer slabs separated by nonmagnetic ions groups. Within each slab, intervalence charge transfer has been found to occur between the Eu2+ Eu3+ Kagomé layers, channel for quantum fluctuation magnetic moments. The measured susceptibilities specific heat capacity exhibit very similar features characteristic spin liquid behaviors observed in other materials.
Abstract Saccharomyces cerevisiae is a widely used cell factory for the production of fuels and chemicals. However, as non‐oleaginous yeast, S. has limited capacity lipophilic compounds, such β‐carotene. To increase its accumulation β‐carotene, we engineered different lipid metabolic pathways in β‐carotene producing strain investigated relationship between components We found that overexpression sterol ester synthesis genes ARE1 ARE2 increased yield by 1.5‐fold. Deletion phosphatidate...
African swine fever is a widespread and highly contagious disease in the porcine population, which caused by virus (ASFV). The PCR ELISA detection methods are main conventional diagnostic for ASFV antigen/antibody field. However, these have limitations of expensive equipment, trained technicians, time-consuming results. Thus, rapid, inexpensive, accurate on-site method urgently needed. Here we describe double-antigen-sandwich lateral-flow assay based on gold nanoparticle-conjugated major...
Perturbation of organic anion transporter (OAT) 1- and OAT3-mediated transport can alter the exposure, efficacy, safety drugs. Although there have been reports endogenous biomarkers for OAT1/3, none these all characteristics required a clinical useful biomarker. Cynomolgus monkeys were treated with intravenous probenecid (PROB) at dose 40 mg/kg in this study. As expected, PROB increased area under plasma concentration-time curve (AUC) coadministered furosemide, known substrate OAT1 OAT3, by...