A5100654881- Alkaline Phosphatase Research Studies
- Cancer Immunotherapy and Biomarkers
- Bone health and treatments
- Functional Brain Connectivity Studies
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Metalloenzymes and iron-sulfur proteins
- Pancreatic and Hepatic Oncology Research
- ATP Synthase and ATPases Research
- Click Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Phytochemical Studies and Bioactivities
- MicroRNA in disease regulation
- Dementia and Cognitive Impairment Research
- Epigenetics and DNA Methylation
- Neural dynamics and brain function
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Reconstructive Surgery and Microvascular Techniques
- Plant Pathogens and Fungal Diseases
- Advanced Neuroimaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
Hunan University of Traditional Chinese Medicine
2021-2025
Nanjing Agricultural University
2025
Medical College of Wisconsin
2015-2024
XinHua Hospital
2010-2024
Shanghai Jiao Tong University
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2024
Peking Union Medical College Hospital
2019-2024
Zhengzhou University
2017-2024
Henan Cancer Hospital
2017-2024
Xiamen University
2024
To investigate whether gut microbiota metabolite sodium butyrate (NaB) is an effective substance for attenuating non-alcoholic fatty liver disease (NAFLD) and the internal mechanisms.Male C57BL/6J mice were divided into three groups, normal control fed standard chow model group a high-fat diet (HFD) 16 wk, intervention HFD wk treated with NaB 8 wk. Gut from each detected at baseline histology evaluated gastrointestinal barrier indicator such as zonula occluden-1 (ZO-1) by...
Sex chromosomes evolved from autosomes many times across the eukaryote phylogeny. Several models have been proposed to explain this transition, some involving male and female sterility mutations linked in a region of suppressed recombination between X Y (or Z/W, U/V) chromosomes. Comparative experimental analysis reference genome assembly for double haploid YY garden asparagus (Asparagus officinalis L.) individual implicates separate but genes as responsible sex determination. Dioecy has...
AIM:To evaluate the performance of a novel non-inva-sive controlled attenuation parameter (CAP) to assess liver steatosis. METHODS:This was multi-center prospective cohort study.Consecutive patients (aged ≥ 18 years) who had undergone percutaneous biopsy and CAP measurement were recruited from three Chinese centers.Steatosis categorized as S0: < 5%; S1: 5%-33%; S2: 34%-66%; or S3: 67%, according nonalcoholic fatty disease (NAFLD) activity score.The FibroScan ® 502 equipped with M probe...
Gastric cancer (GC) is one of the most prominent malignancies that originate in epithelial cells gastric mucosa and main causes cancer-related mortality worldwide. New circulating biomarkers exosomal RNA might have great potential for non-invasive early prognosis GC. Sijunzi Decoction (SJZD) a typical representative formula method benefiting Qi strengthening spleen Traditional Chinese Medicine (TCM). However, effects mechanism SJZD treating GC remain unclear. This study looked GC, explored A...
Heart failure (HF) is a complex syndrome marked by considerable expenditures and elevated mortality morbidity rates globally. Shenmai injection (SMI), form of Traditional Chinese Medicine-based therapy, has demonstrated effectiveness in treating HF. Recent research suggests that Medicine (TCM) may induce beneficial changes microbial-host co-metabolism, potentially providing cardiovascular protection. This study used rat model hypertensive heart (H-HF) to explore the mechanism SMI. The...
It is suggested that structurally segregated and functionally specialized brain regions are mediated by synchrony over large-scale networks in order to provide the formation of dynamic links integration functions. The existence negative synchrony, or functional connectivity (NFC), however, has been a subject debate terms its origin, interpretation, relationship with structural connectivity, possible neurophysiological function. present study, which incorporated 20 cognitively healthy elderly...
Abstract In resting‐state functional MRI studies, the global signal (operationally defined as average of time courses) is often considered a nuisance effect and commonly removed in preprocessing. This regression method can introduce artifacts, such false anticorrelated networks connectivity analyses. Therefore, efficacy this technique correction tool remains questionable. article, we establish that accuracy estimated determined by level noise (i.e., non‐neural has on signal). When low,...
Objective IgG4-related disease (IgG4-RD) is a chronic systemic involved in many organs and tissues. As only limited autoantigens have been found since the beginning of this century, aim study was to reveal new candidate IgG4-RD. Methods Multiple cell lines including HT-29, EA.hy926, HEK 293 HepG2 were used test binding ability circulating autoantibodies from IgG4-RD sera. The amino-acid sequence then analyzed by matrix-assisted laser desorption/ionization time-of-flight tandem...
BACKGROUNDNonalcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases in world.Nowadays, percentage non-obese or lean patients with NAFLD increasing.NAFLD populations, especially subgroup a normal waist circumference (WC), might lead to more problems than obese individuals, as these individuals may not visit clinics for diagnosis ignore NAFLD.If precise characteristics subgroup, are identified, clinicians would be able provide appropriate advice and treatment...
Endoscopic rubber band ligation (ERBL) is a nonsurgical technique for the treatment of symptomatic internal hemorrhoids but limited by recurrence and post-procedural pain.
The apolipoprotein E (APOE) ϵ4 allele is a confirmed genetic risk factor and the APOE ϵ2 protective related to late-onset Alzheimer's disease (AD). Intriguingly, recent studies demonstrated similar brain function alterations between alleles, despite their opposite susceptibilities AD. To address this apparent discrepancy, we recruited 129 cognitively normal elderly subjects, including 36 carriers, 44 ϵ3 homozygotes, 49 carriers. All subjects underwent resting-state functional MRI scans. We...
Previous studies have demonstrated disruption in structural and functional connectivity occurring the Alzheimer's Disease (AD). However, it is not known how these disruptions alter brain network reorganization. With modular analysis method of graph theory, datasets acquired by resting-state MRI (R-fMRI) method, we investigated compared organization patterns between AD group cognitively normal control (CN) group. Our main finding that largest homotopic module (defined as insula module) CN was...
This study based on metabolomics and electronic tongue analysis, investigates the effects of three drying methods—freeze-drying, microwave drying, hot-air drying—on non-volatile metabolites taste Siraitia grosvenorii fruit. The results indicated that both freeze-drying slightly enhanced sweetness content sucrose, grosvenorine, kaempferitrin, whereas increased bitterness. Higher temperatures led to lower contents 18 amino acids, 9 bioactive compounds, soluble sugars, umami values. Taste...