A5079116621- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Peptidase Inhibition and Analysis
- Cardiac Fibrosis and Remodeling
- Cancer Cells and Metastasis
- Diet and metabolism studies
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Antenna Design and Analysis
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Gut microbiota and health
- Nanoplatforms for cancer theranostics
- Pancreatitis Pathology and Treatment
- Cancer Research and Treatments
- Macrophage Migration Inhibitory Factor
- Alcohol Consumption and Health Effects
- Metamaterials and Metasurfaces Applications
- Connective Tissue Growth Factor Research
- Inflammatory Bowel Disease
Feng Chia University
2025
Huadong Hospital
2022-2024
Fudan University
2022-2024
Zhongshan Hospital
2024
Sun Yat-sen University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Southern Taiwan University of Science and Technology
2024
Chinese People's Armed Police Force Engineering University
2018-2023
Bridge University
2023
Wenzhou Medical University
2023
To investigate whether gut microbiota metabolite sodium butyrate (NaB) is an effective substance for attenuating non-alcoholic fatty liver disease (NAFLD) and the internal mechanisms.Male C57BL/6J mice were divided into three groups, normal control fed standard chow model group a high-fat diet (HFD) 16 wk, intervention HFD wk treated with NaB 8 wk. Gut from each detected at baseline histology evaluated gastrointestinal barrier indicator such as zonula occluden-1 (ZO-1) by...
Non-alcoholic steatohepatitis (NASH) is an epidemic metabolic disease with limited therapeutic strategies. Cumulative data support the pivotal role of gut microbiota in NASH. Here, we investigated hypothesis regarding whether fecal transplantation (FMT) effective attenuating high-fat diet (HFD)-induced mice. Mice were randomized into control, HFD and + FMT groups. After 8-week HFD, treatment was initiated carried out for 8 weeks. The structure, butyrate concentrations cecal content, liver...
Glucagon-like peptide-1 (GLP-1) has a broad spectrum of biological activity by regulating metabolic processes via both the direct activation class B family G protein-coupled receptors and indirect nonreceptor-mediated pathways. GLP-1 receptor (GLP-1R) agonists have significant therapeutic effects on non-alcoholic fatty liver disease (NAFLD) steatohepatitis (NASH) in animal models. However, clinical studies indicated that treatment had little effect hepatic steatosis some NAFLD patients,...
Background Hepatitis C virus (HCV) infection has been linked to an increased risk of insulin resistance and carotid atherosclerosis. Aim To investigate the association between HCV stroke, effect interferon-based therapy (IBT) on stroke in chronic hepatitis (CHC) patients. Methods We conducted a retrospective cohort study that followed up 3113 subjects with newly detected 12 452 age- gender-matched without selected from random sample 106 beneficiaries Taiwan National Health Insurance Program...
AIMTo assess disease-specific circulating microRNAs (miRNAs) in non-alcoholic steatohepatitis (NASH) patients. METHODSA total of 111 biopsy-proven fatty liver disease (NAFLD) or chronic hepatitis B (CHB) patients and healthy controls from mainland China were enrolled to measure their serum levels miR-122, -125b, -146b, -16, -21, -192, -27b -34a.The correlations between miRNAs histological features NAFLD determined.The diagnostic value miRNA NASH significant fibrosis was analyzed compared...
Background— The volume overload of isolated mitral regurgitation (MR) in the dog results left ventricular (LV) dilatation and interstitial collagen loss. To better understand mechanism loss, we performed a gene array overlaid regulated genes into ingenuity pathway analysis. Methods Results— Gene arrays from LV tissue were compared 4 dogs before months after MR. Cine-magnetic resonance–derived end-diastolic increased 2-fold ( P =0.005), ejection fraction 41% to 53% <0.007). decreased 40%...
Left ventricular (LV) volume overload (VO) causes eccentric remodeling with inflammatory cell infiltration and extracellular matrix (ECM) degradation, for which there is currently no proven therapy. To uncover new pathways that connect inflammation ECM homeostasis cellular dysfunction, we determined the cardiac transciptome in subacute, compensated, decompensated stages based on vivo hemodynamics echocardiography rat aortocaval fistula (ACF). LV dilatation at 5 wk was associated a normal...
Gastric cancer (GC) is one of the most leading malignancies. Long noncoding RNA related to GC. In this study, 11 miRNAs in exosomes and six lncRNAs tissues was examined by qRT-PCR. Correlation analysis used analyze relationship between exosome tissues. Four level GC were MTT determine cell viability. Flow cytometry quantify apoptotic cells. Transwell assay examine migration invasion capacity. Dual-luciferase interaction HOTAIR miR-30a or -b. Capillary formation capillary Weak negative...
In this article, an additional protected fiber and free-space optical (FSO) link path is proposed, to provide self-healing capabilities for protection against faults in wavelength division multiplexed passive network (WDM-PON) systems. The new line terminal (OLT), remote node (RN), unit (ONU) the presented PON architecture result self-protective function breakpoints. measurement, 25 Gbit/s on-off keying (OOK) modulation was applied on each WDM channel assess downstream upstream signals after...
Background The clinical problem of a "pure volume overload" as in isolated mitral or aortic regurgitation currently has no documented medical therapy that attenuates collagen loss and the resultant left ventricular (LV) dilatation failure. Here, we identify potential mechanism related to upregulation kallikrein-kinin system overload aortocaval fistula (ACF) rat. Methodology/Principal Findings LV interstitial fluid (ISF) collection, hemodynamics, echocardiography were performed age-matched...
Abstract Background and Aim Enterohepatic immunologic derangement is associated with non‐alcoholic steatohepatitis. Here, we investigated whether Clostridium butyricum B1 (CB) would be an effective immune‐targeted substance to attenuate steatohepatitis in mice. Methods Thirty mice were randomized into a control group fed common forage, high‐fat diet (HFD) HFD for 16 weeks, + CB treated the latter 8 weeks. Inflammation‐associated or metabolism‐associated genes liver epididymal fat tissue...
Due to the influence of mass law, traditional lightweight sandwich structures have struggled surpass solid in sound insulation performance. To this end, we propose an acoustic metamaterial structure with a configuration based on re-entrant negative Poisson’s ratio (NPR) and systematically investigate its transmission loss (STL) performance under incident plane wave conditions. We used impedance tube method experimentally study NPR free boundary conditions, then established analysis...
Background— The left ventricular (LV) dilatation of isolated mitral regurgitation (MR) is associated with an increase in chymase and a decrease interstitial collagen extracellular matrix. In addition to profibrotic effects, has significant antifibrotic actions because it activates matrix metalloproteinases kallikrein degrades fibronectin. Thus, we hypothesize that inhibitor (CI) will attenuate loss LV remodeling MR. Methods Results— We studied dogs 4 months untreated MR (MR; n=9) or treated...
Both nonalcoholic fatty liver disease (NAFLD) and cholelithiasis are highly prevalent hepatobiliary diseases with risk of progression into severe outcomes. Considering the close relationship between gallbladder in anatomy physiology, a potential causal NAFLD has been speculated.
Objective:The fecal microbiota was studied in patients with inflammatory bowel disease (IBD), and the characteristics of gut were compared among different subtypes stages IBD, aiming to identify associated IBD.Methods: Fecal samples collected from 41 IBD (18 ulcerative colitis [UC] 23 Crohn's [CD]) Department Gastroenterology East China Hospital, Fudan University between January 2021 2022.In addition, 20 healthy volunteers.The subjected 16S rRNA gene sequencing, followed by bioinformatics...
This study aimed to assess the impact of perinatal high-fat (HF) diet in female Sprague-Dawley rats (F0) on glucose metabolism and islet function their early life second-generation offspring (F2). F0 were fed with a standard chow (SC) or HF for 8 weeks before mating, up termination lactation first-generation (F1-SC F1-HF). F1 females mated normal males at age week 11, producing F2 (F2-SC, F2-HF). All SC after weaning 3 weeks. The level assessed 12. F2-HF had high birth weight maintained...