A5057357760- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- ATP Synthase and ATPases Research
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Cardiac Ischemia and Reperfusion
- Diet and metabolism studies
- Air Quality and Health Impacts
- Cancer Genomics and Diagnostics
- Neonatal Respiratory Health Research
- Autophagy in Disease and Therapy
- Cardiovascular Function and Risk Factors
- Medical Imaging and Pathology Studies
- Microtubule and mitosis dynamics
- Renal and related cancers
- Birth, Development, and Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Cells and Metastasis
- Redox biology and oxidative stress
- Liver Disease Diagnosis and Treatment
University of Alabama at Birmingham
2016-2025
Mitochondria Research and Medicine Society
2014-2019
Ball (France)
2019
Louisiana State University Health Sciences Center Shreveport
2016
University of Pennsylvania
2016
Queen's University
2016
Boston University
2016
The University of Kansas Cancer Center
2013
University of Kansas Medical Center
2013
University of Alabama
2013
Coronary atherosclerotic disease remains the leading cause of death in Western world. Although exact sequence events this process is controversial, reactive oxygen and nitrogen species (RS) likely play an important role vascular cell dysfunction atherogenesis. Oxidative damage to mitochondrial genome with resultant consequence increased intracellular RS.We examined contribution oxidant generation DNA progression lesions human arterial specimens atherosclerosis-prone mice. Mitochondrial not...
Abstract —The mechanisms by which reactive species (RS) participate in the development of atherosclerosis remain incompletely understood. The present study was designed to test hypothesis that RS produced vascular environment cause mitochondrial damage and dysfunction vitro and, thus, may contribute initiating events atherogenesis. DNA assessed cells exposed superoxide, hydrogen peroxide, nitric oxide, peroxynitrite. In both endothelial smooth muscle cells, (mtDNA) preferentially damaged...
Human mitochondrial DNAs (mtDNAs) from 153 independent samples encompassing seven Asian populations were surveyed for sequence variation using the polymerase chain reaction (PCR), restriction endonuclease analysis and oligonucleotide hybridization. All found to share two ancient AluI/DdeI polymorphisms at nps 10394 10397 be genetically similar indicating that they a common ancestry. The greatest mtDNA diversity highest frequency of mtDNAs with HpaI/HincII morph 1 observed in Vietnamese...
Peripheral blood mononuclear cells and platelets have long been recognized as having the potential to act sensitive markers for mitochondrial dysfunction in a broad range of pathological conditions. However, bioenergetic function these has not examined from same donors, yet this is important selection cell types translational studies. Here, we demonstrate measurement cellular bioenergetics isolated human monocytes, lymphocytes, platelets, including oxidative burst neutrophils monocytes...
Endogenously formed reactive oxygen species continuously damage cellular constituents including DNA. These challenges, coupled with exogenous exposure to agents that generate species, are both associated normal aging processes and linked cardiovascular disease, cancer, cataract formation, fatty liver disease. Although not all of these diseases have been definitively shown originate from mutations in nuclear DNA or mitochondrial DNA, repair oxidized, saturated, ring-fragmented bases via the...
Background — A shared feature among cardiovascular disease risk factors is increased oxidative stress. Because mitochondria are susceptible to damage mediated by stress, we hypothesized that (secondhand smoke and hypercholesterolemia) associated with mitochondrial in tissues. Methods Results Atherosclerotic lesion formation, DNA damage, protein nitration, specific activities of proteins tissues from age-matched C57 apoE −/− mice exposed filtered air or secondhand were quantified. Both...
Sympatric populations of white-tailed deer and mule (Odocoileus virginianus Odocoileus hemionus, respectively) on a west Texas ranch share common mitochondrial DNA restriction map genotype. Phylogenetic analysis indicates that this genotype is more characteristic O. than hemionus. The differs from South Carolina by five mutational events (1.3% sequence divergence), whereas it hemionus California 17 (5.5% divergence). We suggest interspecies hybridization has occurred, primarily between bucks...
More than 100 million people in the United States live areas that exceed current ozone air quality standards. In addition to its known pulmonary effects, environmental exposures have been associated with increased hospital admissions related cardiovascular events, but date, no studies elucidated potential molecular mechanisms may account for exposure-related vascular impacts. Because of redox and immune biology stemming from exposure, we hypothesized inhalation would initiate oxidant stress,...
Prior studies demonstrate mitochondrial dysfunction with increased reactive oxygen species generation in peripheral blood mononuclear cells diabetes mellitus. Oxidative stress-mediated damage to DNA promotes atherosclerosis animal models. Thus, we evaluated the relation of s vascular function patients mellitus and atherosclerotic cardiovascular disease. We assessed non-invasive 275 (age 57 ± 9 years, 60 % women) disease alone (N = 55), 74), combined 48), controls age >45 without or 98)....
Elevated infiltration of immunosuppressive alternatively polarized (M2) macrophages is associated with poor prognosis in patients cancer. The tumor microenvironment remarkably orchestrates molecular mechanisms that program these macrophages. Here we identify a novel role for oncogenic Hedgehog (Hh) signaling programming signature metabolic circuitries regulate alternative polarization tumor-associated Two immunocompetent orthotopic mouse models mammary tumors were used to test the effect...
Mitochondria are particularly susceptible to increased formation of reactive oxygen and nitrogen species in the cell that can occur response pathological xenobiotic stimuli. Proteomics give insights into both mechanism pathology adaptation stress. Herein we report use proteomics evaluate alterations levels mitochondrial proteins following chronic ethanol exposure an animal model. Forty-three showed differential expression, 13 30 decreased, as a consequence ethanol. Of these proteins, 25 were...
Subacute necrotizing encephalopathy (SNE) or Leigh9s disease is associated with various defects in oxidative phosphorylation (OXPHOS). However, the relationships between these OXPHOS and nuclear DNA mitochondrial (mtDNA) mutations still unclear. We evaluated three SNE pedigrees (two singleton cases a pedigree) biochemically for abnormalities genetically four mtDNA point mutations. There was complex I defect ail that III two individuals. An mutation ATPase, subunit 6 gene (np 8993) present...