A5022450169- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Glaucoma and retinal disorders
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Liver Disease and Transplantation
- Pancreatic function and diabetes
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Diseases and Immunity
- Child Nutrition and Water Access
- Nutritional Studies and Diet
- Genomics, phytochemicals, and oxidative stress
- Liver physiology and pathology
- Diabetes Treatment and Management
- Drug-Induced Hepatotoxicity and Protection
- Cerebral Venous Sinus Thrombosis
- Retinal Diseases and Treatments
- Antioxidant Activity and Oxidative Stress
- Gout, Hyperuricemia, Uric Acid
- Fibroblast Growth Factor Research
- Diabetes and associated disorders
Xian Yang Central Hospital
2022-2025
Tianjin People's Hospital
2015-2025
Second Hospital of Tianjin Medical University
2022-2025
Tianjin Medical University
2011-2025
Tianjin Infectious Diseases Hospital
2009-2025
Soochow University
2023-2025
Wuxi Ninth People's Hospital
2025
Kanazawa University
2015-2024
Wenzhou Medical University
2019-2024
Shandong Provincial Hospital
2016-2024
Sodium-glucose cotransporter (SGLT) 2 inhibitors increase urinary glucose excretion (UGE), leading to blood reductions and weight loss. However, the impacts of SGLT2 inhibition on energy homeostasis obesity-induced insulin resistance are less well known. Here, we show that empagliflozin, a inhibitor, enhanced expenditure attenuated inflammation in high-fat-diet-induced obese (DIO) mice. C57BL/6J mice were pair-fed high-fat diet (HFD) or HFD with empagliflozin for 16 weeks. Empagliflozin...
Dipeptidyl peptidase 4 (DPP-4) cleaves a large number of chemokine and peptide hormones involved in the regulation immune system. Additionally, DPP-4 may also be macrophage-mediated inflammation insulin resistance. Thus, current study investigated effect linagliptin, an inhibitor DPP-4, on macrophage migration polarization white adipose tissue (WAT) liver high-fat diet-induced obese (DIO) mice. DPP-4(+) macrophages lean mice were quantified by fluorescence-activated cell sorting (FACS)...
Low-grade sustained inflammation links obesity to insulin resistance and nonalcoholic fatty liver disease (NAFLD). However, therapeutic approaches improve systemic energy balance chronic in are limited. Pharmacological activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) alleviates mice; however, Nrf2 inducers not clinically available owing safety concerns. Thus, we examined whether dietary glucoraphanin, a stable precursor the inducer sulforaphane, ameliorates balance,...
AIM:To evaluate the performance of a novel non-inva-sive controlled attenuation parameter (CAP) to assess liver steatosis. METHODS:This was multi-center prospective cohort study.Consecutive patients (aged ≥ 18 years) who had undergone percutaneous biopsy and CAP measurement were recruited from three Chinese centers.Steatosis categorized as S0: < 5%; S1: 5%-33%; S2: 34%-66%; or S3: 67%, according nonalcoholic fatty disease (NAFLD) activity score.The FibroScan ® 502 equipped with M probe...
Objective We reported previously that empagliflozin—a sodium-glucose cotransporter (SGLT) 2 inhibitor—exhibited preventive effects against obesity. However, it was difficult to extrapolate these results human subjects. Here, we performed a therapeutic study, which is more relevant clinical situations in humans, investigate antiobesity of empagliflozin and illustrate the mechanism underlying empagliflozin-mediated enhanced fat browning obese mice. Research design methods After 8 weeks on...
<h2>Summary</h2><h3>Background</h3> With increasingly prevalent coexistence of chronic hepatitis B (CHB) and hepatic steatosis (HS), simple, non-invasive diagnostic methods to accurately assess the severity inflammation are needed. We aimed build a machine learning (ML) based model detect in patients with CHB concurrent HS. <h3>Methods</h3> conducted multicenter, retrospective cohort study China. Treatment-naive biopsy-proven HS between April 2004 September 2022 were included. The optimal...
Controlled attenuation parameter (CAP) is a non-invasive method for evaluating hepatic steatosis. However, larger skin capsular distance (SCD) can affect the accuracy. The aim of this study was to investigate impact SCD on diagnostic performance CAP and liver stiffness measurement (LSM).Of 101 patients with non-alcoholic fatty disease (NAFLD) 280 chronic hepatitis B (CHB) who underwent biopsy were prospectively recruited. CAP, LSM performed using FibroScan M probe. areas under receiver...
Hyperuricemia drives the development of nonalcoholic fatty liver disease (NAFLD). Pharmacological inhibition xanthine oxidase (XO), a rate-limiting enzyme for uric acid (UA) production, has been demonstrated to improve hepatic steatosis in diet-induced obese mice. However, it remains unclear whether XO improves steatohepatitis (NASH), more advanced form NAFLD, terms both inflammation and fibrosis. Here, we investigated effects febuxostat allopurinol, two inhibitors clinically used gout, on...
Metabolic intervention is a novel anti-rheumatic approach. The glycolytic regulator NAMPT has been identified as therapeutic target of rheumatoid arthritis (RA), while other metabolic regulators coordinating to perpetuate inflammation are yet be investigated. We continuously monitored and validated expression changes Nampt inflammatory indicators in peripheral blood cells from rats with collagen-induced (CIA). Gene transcriptional profiles Nampt+ Nampt++ samples identical CIA were compared...
Adipose tissue macrophage (ATM) recruitment and polarization are pivotal in the development of insulin resistance. However, treatment modalities targeting ATMs remain limited. The effects lycopene, an antioxidant carotenoid compound, on adipose inflammation resistance high fat (HF)-diet-induced obese mice examined.C57BL/6J fed HF diet or containing lycopene (HF+LY) for 8 weeks. Lycopene attenuates HF-diet-induced glucose intolerance hyperinsulinemia. Compared with mice, HF+LY exhibit...
Summary Background Liver stiffness measurement (LSM) by transient elastography is a noninvasive method for the diagnosis of hepatic fibrosis. The impact steatosis on LSM remains to be explored. Aim To determine whether affected in patients with chronic hepatitis B (CHB). Methods Consecutive biopsy‐proven CHB were prospectively enrolled. Hepatic was classified pathology as none (S0, <5%), mild (S1, 5%‐33%), and moderate‐severe (S2‐3, >33%), quantitatively controlled attenuation...
Abstract Backgrounds/objectives Melatonin promotes brown adipose tissue (BAT) activity, leading to body mass reduction and energy expenditure. However, the mechanisms governing these beneficial effects are not well-established. This study aimed assess of (1) melatonin on BAT metabolism, (2) fibroblast growth factor 21 (FGF21) in BAT-mediated thermogenesis. Methods Male C57BL/6 J mice received a high-fat diet (HFD) or normal chow, accompanied by intraperitoneal injection 20 mg/kg for 12...
Abstract Background: Liver biopsy for the diagnosis of non-alcoholic steatohepatitis (NASH) is limited by its inherent invasiveness and possible sampling errors. Some studies have shown that cytokeratin-18 (CK-18) concentrations may be useful in diagnosing NASH, but results across been inconsistent. We aimed to identify utility CK-18 M30 as an alternative liver non-invasive identification NASH. Methods: Individual data were collected from 14 registry centers on patients with biopsy-proven...
Background and Aims: Hepatocellular carcinoma (HCC) poses a significant global health burden, with hepatitis B virus (HBV) being the predominant etiology in China. However, current diagnostic markers lack requisite sensitivity specificity. This study aims to develop validate serum N-glycomics-based models for diagnosis prognosis of HCC patients chronic (CHB)-related cirrhosis. Approach Results: enrolled total 397 CHB-related cirrhosis clinical management. N-glycomics profiling was conducted...