A5039116052- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Liver Diseases and Immunity
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Kruppel-like factors research
- Pancreatic function and diabetes
- Liver physiology and pathology
- Adsorption and biosorption for pollutant removal
- Inflammatory Bowel Disease
- Ferroptosis and cancer prognosis
- Flame retardant materials and properties
- Diabetes and associated disorders
- Gut microbiota and health
- Drug-Induced Hepatotoxicity and Protection
- Fluoride Effects and Removal
- Polymer Nanocomposites and Properties
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Helicobacter pylori-related gastroenterology studies
- Muscle and Compartmental Disorders
- Macrophage Migration Inhibitory Factor
- Salivary Gland Disorders and Functions
- Nigella sativa pharmacological applications
Wenzhou Medical University
2009-2025
First Affiliated Hospital of Wenzhou Medical University
2019-2025
Ocean University of China
2024
Jining Medical University
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2023
Qinghai University
2022-2023
Abstract Background and Aims NAFLD represents an increasing health problem in association with obesity diabetes no effective pharmacotherapies. Growing evidence suggests that several FGFs play important roles diverse aspects of liver pathophysiology. Here, we report a previously unappreciated role FGF4 the liver. Approach Results Expression hepatic is inversely associated pathological grades both human patients mouse models. Loss Fgf 4 aggravates steatosis damage resulted from obesogenic...
Autoimmune hepatitis (AIH) is increasingly affecting human health but pharmacotherapies remain to be identified. Growing evidence reveals that ferroptosis, a newly recognized form of programmed cell death, critical for AIH. However, the exact mechanisms ferroptotic cascade elusive. Data in this study showed ferroptosis aggravation was associated with protectively-elevated fibroblast growth factor 4 (FGF4) expression Concanavalin A (ConA)-induced AIH liver injury, these effects being...
1Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, The First Affiliated Hospital Wenzhou Medical University, 325035, Zhejiang, China 2Department Respiratory Medicine, Abbreviations: AFP, Alpha-fetoprotein; DCR, Disease control rate; ECOG, Eastern Cooperative Oncology Group; HCC, Hepatocellular carcinoma; ORR, Objective response PVTT, Portal vein tumor thrombosis; Sin-Bev-RT, Sintilimab Bevacizumab combined with Radiotherapy Correspondence Su...
Autoimmune hepatitis (AIH) is an inflammatory autoimmune disease of the liver. Oxidative stress triggered by reactive oxygen radicals a common pathophysiological basis for pathogenesis many liver diseases, and ferroptosis associated with toxic accumulation species. The signaling transduction pathways responsible iron processing lipid‐peroxidation mechanisms are believed to drive ferroptosis. However, specific regulating remain unclear. aims this investigation were identify possible effector...
Abstract Autoimmune hepatitis (AIH) is an immune-mediated inflammatory liver disease with unclear pathogenesis. The gut microbiota and intestinal barrier play essential role in AIH. Polymeric immunoglobulin receptor (pIgR) a central component of mucosal immunity. Herein, we aimed to test the hypothesis that pIgR plays pivotal maintaining homeostasis integrity AIH mouse model. expression shows variation tendency falling after rising aggravation experimental (EAH). deletion Pigr exacerbates...
Abstract Background Ribosomal RNA processing protein 15 (RRP15) has been found to regulate the progression of hepatocellular carcinoma (HCC). Nevertheless, extent which it contributes spread HCC cells remains uncertain. Thus, objective this research was assess biological function RRP15 in migration HCC. Methods The expression tissue microarray (TMA), tumor tissues and cell lines were determined. In vitro, effects knockdown on migration, invasion adhesion ability assessed by wound healing...
Background and Aims: Alcoholic liver disease (ALD) represents a critical global health challenge characterized by damage resulting from excessive alcohol consumption. Early detection timely intervention are essential for optimizing patient outcomes. However, the mechanisms underlying alcohol-induced injury have not been fully elucidated. Fibroblast growth factor 4 (FGF4) has implicated in progression of various diseases. This study aims to elucidate role FGF4 pathogenesis ALD. Approach...
Background Research into the “gut–lung” axis links gut microbiota to pulmonary artery hypertension (PAH). However, mechanisms by which influence PAH remain unclear. We aimed investigate causal relationship between and using Mendelian randomization analysis, identify key metabolites, explore regulatory role of associated genes in pathogenesis. Methods Results examined association taxa inverse variance weighted 2‐sample randomization–Egger, median, mode methods. Additionally, we identified...
Introduction Enteric dysbacteriosis is strongly associated with nonalcoholic fatty liver disease (NAFLD). However, the underlying causal relationship remains unknown. Thus, present study aimed to investigate between gut microbiota and NAFLD using Mendelian randomization (MR) analyze target genes potentially regulated by specific microbiota. Methods Bidirectional two-sample MR analysis was performed inverse variance weighted (IVW) supplemented MR-Egger, median, simple mode, mode methods. Data...
Abstract Autoimmune hepatitis (AIH) is a chronic liver disease due to autoimmune system attacks hepatocytes and causes inflammation fibrosis. Intracellular signalling miRNA may play an important role in regulation of injury. This study aimed investigate the potential roles microRNA 143 murine AIH model hepatocyte injury model. Murine was induced by hepatic antigen S100, LPS. Mice AML12 cells were separated into six groups with or without treatment miRNA‐143. Inflammation fibrosis as well...
The poor processing and rheological properties of highly filled composites caused by the high loading fillers can be improved with use maleic anhydride grafted polyethylene wax (PEWM) as compatibilizer lubricant. In this study, two PEWMs different molecular weights were synthesized melt grafting, their compositions grafting degrees characterized Fourier transform infrared (FTIR) spectroscopy acid-base titration. Subsequently, magnesium hydroxide (MH)/linear low-density (LLDPE) 60 wt% MH...
Acute liver failure (ALF) poses a serious public health issue. The menstrual blood-derived mesenchymal stem cells (MenSCs) have been applied to cure various liver-related diseases. However, the efficacy and mechanism are far from clear. This study aims explore potential of MenSCs ALF. We investigate on ALF in vitro vivo. A2A adenosine receptor (A2AR) activation was investigated as reinforcer for treatment. Lipid polysaccharide/d-galactosamine (d-GalN) employed induce Diverse techniques were...
Cryptococcal meningitis (CM) is a not rare condition in HIV-negative patients. Here, we describe the clinical characteristics, possible risk factors, and outcomes of patients with CM.Medical records from 99 CM admitted to our hospital 2010 2021 were reviewed systematically. We compared features between underlying diseases otherwise healthy hosts.The had mean age at presentation 56.2 ± 16.2 years, female-to-male ratio was 77:22. A total 52 (52.5%) conditions, 47 (47.5%) no conditions. Kidney...
Abstract The application of highly filled composites is limited by their poor processing and rheological properties due to the high loading fillers. One possible solution this problem use maleic anhydride grafted polypropylene (MAPP) with melt index as compatibilizer lubricant. Herein, magnesium hydroxide (MH)/linear low‐density polyethylene (LLDPE) 60 wt% MH were prepared using MAPP three different flow indexes (MFI). equilibrium torque tests show that addition MFI significantly improves...
Impaired intestinal barrier function and oxidative stress injury play critical roles in the pathogenesis of alcoholic liver disease (ALD), recent investigations have revealed a role for dietary copper function. Therefore, current study investigates mechanisms alcohol induced diseases. C57BL/6 mice were used to create an model with Lieber-DeCarli diet containing 5% fed different concentrations adequate (6 ppm, CuA), marginal (1.5 CuM), or supplemental (20 CuS) amounts. Caco-2 cells also...