A5082837322- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- Neuroscience and Neuropharmacology Research
- Transplantation: Methods and Outcomes
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Biochemical effects in animals
- Mesenchymal stem cell research
- Alcohol Consumption and Health Effects
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Macrophage Migration Inhibitory Factor
- Electron Spin Resonance Studies
- Cancer-related molecular mechanisms research
- Gas Sensing Nanomaterials and Sensors
- Gallbladder and Bile Duct Disorders
- Genomics, phytochemicals, and oxidative stress
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Nitric Oxide and Endothelin Effects
- Hepatitis C virus research
Wenzhou Medical University
2014-2025
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Hangzhou Medical College
2022-2025
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2025
University of Hong Kong
2015-2024
Zhejiang University
2016-2024
Peking University First Hospital
2019-2022
Peking University
2019-2022
Southwest Jiaotong University
2011-2022
Yibin University
2021
Liver cirrhosis is one of the major consequences hepatitis B virus (HBV) infection, and transplantation autologous bone marrow mesenchymal stem cells (ABMSCs) promising therapies for patients with HBV-related liver (HBV-LC). However, mechanism unclear. The aim current study was to explore role Treg/Th17 in ABMSCs HBV-LC.In this prospective study, 56 were enrolled randomly assigned group control group. After 24-week follow-up, 39 completed (20 cases 19 group). Model End-Stage Disease scores,...
MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and highly encased exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able function as carriers deliver into cells. Autoimmune hepatitis challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether can transfer miR-223-3p treat autoimmune an experimental model. We...
Autoimmune hepatitis (AIH) is an inflammatory autoimmune disease of the liver. Oxidative stress triggered by reactive oxygen radicals a common pathophysiological basis for pathogenesis many liver diseases, and ferroptosis associated with toxic accumulation species. The signaling transduction pathways responsible iron processing lipid‐peroxidation mechanisms are believed to drive ferroptosis. However, specific regulating remain unclear. aims this investigation were identify possible effector...
Abstract Autoimmune hepatitis (AIH) is an immune-mediated inflammatory liver disease with unclear pathogenesis. The gut microbiota and intestinal barrier play essential role in AIH. Polymeric immunoglobulin receptor (pIgR) a central component of mucosal immunity. Herein, we aimed to test the hypothesis that pIgR plays pivotal maintaining homeostasis integrity AIH mouse model. expression shows variation tendency falling after rising aggravation experimental (EAH). deletion Pigr exacerbates...
To develop and validate a deep learning signature for noninvasive prediction of spread through air spaces (STAS) in clinical stage I lung adenocarcinoma compare its predictive performance with conventional clinical-semantic model. A total 513 patients pathologically-confirmed were retrospectively enrolled divided into training cohort (n = 386) independent validation 127) according to different center. Clinicopathological data collected CT semantic features evaluated. Multivariate logistic...
Rheumatoid arthritis (RA) is a debilitating systemic autoimmune disorder that significantly impairs quality of life. To elucidate the molecular alterations in RA progression, we performed comprehensive super-omics analyses on synovial tissues from patients with joint trauma, arthritis, and RA. These included transcriptomics, proteomics, metabolomics, microbiomics, fourteen PTMs (phosphorylation, acetylation, lactylation, O-GlcNAc glycosylation, arginine monomethylation, lysine dimethylation,...
Abstract Autoimmune hepatitis (AIH) is a chronic liver disease due to autoimmune system attacks hepatocytes and causes inflammation fibrosis. Intracellular signalling miRNA may play an important role in regulation of injury. This study aimed investigate the potential roles microRNA 143 murine AIH model hepatocyte injury model. Murine was induced by hepatic antigen S100, LPS. Mice AML12 cells were separated into six groups with or without treatment miRNA‐143. Inflammation fibrosis as well...
Abstract Background The global prevalence of autoimmune hepatitis (AIH) is increasing due in part to the lack effective pharmacotherapies. Growing evidence suggests that fibroblast growth factor 4 (FGF4) crucial for diverse aspects liver pathophysiology. However, its role AIH remains unknown. Therefore, we investigated whether FGF4 can regulate M1 macrophage and thereby help treat inflammation AIH. Methods We obtained transcriptome-sequencing clinical data patients with Mice were injected...
The present study evaluated the potential combined effects of NAFLD and MetS on development osteoporosis. relationship between osteoporosis was assessed in 938 postmenopausal female participants. Moderate severe NAFLDs were as significant (SNAFLD). All subjects divided into 4 subgroups based status SNAFLD MetS. Relative excess risk interaction (RERI), attributable proportion (AP) interaction, synergy index (SI) used to investigate additive those two factors. NAFLD, SNAFLD, independent...
Acute liver failure (ALF) poses a serious public health issue. The menstrual blood-derived mesenchymal stem cells (MenSCs) have been applied to cure various liver-related diseases. However, the efficacy and mechanism are far from clear. This study aims explore potential of MenSCs ALF. We investigate on ALF in vitro vivo. A2A adenosine receptor (A2AR) activation was investigated as reinforcer for treatment. Lipid polysaccharide/d-galactosamine (d-GalN) employed induce Diverse techniques were...
Abstract Autoimmune hepatitis (AIH) is a progressive and chronic inflammatory disease in the liver. MARCO surface receptor of macrophage involving tissue inflammation immune disorders. Moreover, polyguanine (PolyG) considered to bind with collagenous structure (MARCO). However, role PolyG development treatment AIH still remains unclear. Therefore, this study explores expression therapeutic activity both S100‐induced mouse Lipopolysaccharide (LPS)‐treated (RAW264.7 cells). there were...
Indole-3-carbinol (I3C) is a phytochemical (derived from broccoli, cabbage, and other cruciferous vegetables) with proven anticancer efficacy including the reduction of cervical intraepithelial neoplasia (CIN) its progression to cancer. In breast cancer cell line, I3C inhibited adhesion, spreading, invasion associated an upregulation tumor suppressor gene PTEN, suggesting that PTEN important in inhibition late stages development The goal this study was determine expression during whether...