A5101930491- Receptor Mechanisms and Signaling
- Cardiac Ischemia and Reperfusion
- Atherosclerosis and Cardiovascular Diseases
- Ion channel regulation and function
- Cardiac Fibrosis and Remodeling
- PARP inhibition in cancer therapy
- Cardiac electrophysiology and arrhythmias
- Nitric Oxide and Endothelin Effects
- Viral Infections and Immunology Research
- MicroRNA in disease regulation
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Erythropoietin and Anemia Treatment
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Mesenchymal stem cell research
- Neonatal Health and Biochemistry
- Phytochemicals and Medicinal Plants
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Tissue Engineering and Regenerative Medicine
- Liver Disease and Transplantation
Shanxi Medical University
2013-2025
Beihang University
2025
Honghu Hospital of Traditional Chinese Medicine
2024
West China Medical Center of Sichuan University
2023
Google (United States)
2023
Air Force Medical University
2017-2022
Xijing Hospital
2020
Tang Du Hospital
2019
Temple University
2013-2014
Wenzhou Medical University
2014
Rationale: Coronary artery ligation to induce myocardial infarction (MI) in mice is typically performed by an invasive and time-consuming approach that requires ventilation chest opening (classic method), often resulting extensive tissue damage high mortality. We developed a novel rapid surgical method MI does not require ventilation. Objective: The purpose of this study was develop comprehensively describe directly compare it the classic method. Methods Results: Male C57/B6 were grouped...
X-linked lymphoproliferative syndrome (XLP) is an inherited immunodeficiency characterized by increased susceptibility to Epstein–Barr virus (EBV). In affected males, primary EBV infection leads the uncontrolled proliferation of virus-containing B cells and reactive cytotoxic T cells, often culminating in development high-grade lymphoma. The XLP gene has been mapped chromosome band Xq25 through linkage analysis discovery patients harboring large constitutional genomic deletions. We describe...
ABSTRACT Cerebral venous sinus thrombosis (CVST) is frequently observed in younger adults and features large thrombus volume. Due to the triangular-like cross-sectional shape diameter of superior sagittal sinus, all commercially available artery stent retrievers are not suitable for vessels. In this study, a dumbbell-like was designed fabricated by 3D braided technology using NiTi wires; it manually rotatable stretchable with controlled length/diameter ratios (2.6–14.0) reciprocating...
Liver cirrhosis is one of the major consequences hepatitis B virus (HBV) infection, and transplantation autologous bone marrow mesenchymal stem cells (ABMSCs) promising therapies for patients with HBV-related liver (HBV-LC). However, mechanism unclear. The aim current study was to explore role Treg/Th17 in ABMSCs HBV-LC.In this prospective study, 56 were enrolled randomly assigned group control group. After 24-week follow-up, 39 completed (20 cases 19 group). Model End-Stage Disease scores,...
Coronary microvascular dysfunction serves as one of the etiological factors for ischemic heart disease and represents a novel therapeutic direction coronary artery diseases; however, research on its pathogenesis remains inconsistent. This study aims to explore single-cell gene expression profiles in rats with using RNA sequencing, particular focus in-depth analysis endothelial cell characteristics. By establishing rat model dysfunction, we collected cardiac apical tissue prepare suspensions...
Studies from our lab have shown that decreasing myocardial G protein-coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after infarction. Since GRK2 appears to also act as a pro-death in myocytes, we investigated the effect of cardiomyocyte-specific ablation on acute response cardiac ischemia/reperfusion (I/R) injury. To do this utilized two independent lines knockout (KO) mice where gene was deleted only cardiomyocytes either constitutively at...
Abstract Increased vascular resistance in the fetoplacental circulation is a characteristic of preeclampsia. However, potential molecular mechanisms this condition remain obscure. The current study aimed to determine direct effect peptide antigen corresponding second extracellular loop angiotensin II type 1 receptor (AT1R‐EC ) activating autoantibody (AT1‐AA), novel risk factor preeclamptic patients, on villus stem blood vessels. Immunohistochemistry revealed that AT1 receptors were...
Abstract Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis. However, whether increased Omi/HtrA2 within mitochondria itself influences myocardial survival in vivo unknown. aim to observe the effects mitochondria-specific, not cytoplasmic, on and cardiac function. Transgenic mice overexpressing cardiac-specific mitochondrial were generated they...
Aim As technological interventions treating acute myocardial infarction (MI) improve, post-ischemic heart failure increasingly threatens patient health. The aim of the current study was to test whether FADD could be a potential target gene therapy in treatment failure. Methods Cardiomyocyte-specific knockout mice along with non-transgenic littermates (NLC) were subjected 30 minutes ischemia followed by 7 days reperfusion or 6 weeks permanent via ligation left main descending coronary artery....
Sustained cardiac hypertrophy often develops maladaptive myocardial remodeling, and eventually progresses to heart failure sudden death. Therefore, is considered as a critical therapeutic target for many diseases. Mitophagy, crucial mechanism in mitochondria quality control cellular homeostasis, has been implicated diverse disorders such infarction, diabetic cardiomyopathy, failure. However, what role mitophagy plays diseases remains an enigma. PARKIN functions E3 ubiquitin protein ligase...
We present Dragon TF Association Miner (DTFAM), a system for text-mining of PubMed documents potential functional association transcription factors (TFs) with terms from Gene Ontology (GO) and diseases. DTFAM has been trained tested in the selection relevant on manually curated dataset containing >3000 abstracts to control. On our test data achieves sensitivity 80% specificity 82%. provides comprehensive tabular graphical reports linking sets documents. These are color-coded easier...
The age-related loss of anti-oxidant defense reduces recovery from myocardial ischemia/reperfusion injury (MI/R) in aged people. Our previous data showed that inactivation thioredoxin (Trx) was involved enhanced aging MI/R injury. Thioredoxin reductase (TrxR), the enzyme known to regulate Trx, is less efficient with age. aim current study determine why TrxR activity reduced and whether contributed Both Trx were decreased heart, this difference further amplified after MI/R. However, did not...
Lung cancer is the most common type of worldwide, prevalent form which non‑small cell lung (NSCLC). MicroRNAs (miRs) are involved in progression NSCLC; however, specific function miR‑140‑5p NSCLC remains unclear. The present study demonstrated that was downregulated tumor tissues patients with NSCLC, and it associated a poor prognosis. Furthermore, significantly suppressed migration invasion line A549. In addition, direct regulatory effect on vascular endothelial growth factor‑A (VEGFA)...
Metabolic syndrome (MetS) includes obesity, diabetes, dyslipidemia and hypertension. Its incidence is rapidly increasing worldwide, particularly in postmenopausal women. Estrogens regulate glucose homeostasis lipid metabolism via estrogen receptors 1 (ESR1) 2 (ESR2). The current study aimed to elucidate associations of MetS with ESR1 ESR2 gene polymorphisms Chinese This case-control included 304 women (154 150 control patients, respectively). Clinical indicators related were assessed. Two...
Sustained cardiac hypertrophy damages the heart and weakens function, often leading to failure even death. Pathological has become a central therapeutic target for many diseases including failure. However, underlying mechanisms of hypertrophy, especially involvement autophagy program, are still ill-understood. Synaptotagmin-7 (Syt7), multifunctional high-affinity calcium sensor, plays pivotal role in asynchronous neurotransmitter release, synaptic facilitation, vesicle pool regulation during...