Background— Alterations in cardiac energy metabolism downstream of neurohormonal stimulation play a crucial role the pathogenesis heart failure. The chronic adrenergic that accompanies failure is signaling abnormality leads to upregulation G protein–coupled receptor kinase 2 (GRK2), which pathological myocyte during disease progression part owing uncoupling β-adrenergic system. In this study, we explored possibility enhanced GRK2 expression and activity, as seen failure, can negatively...

Abstract Necroptosis is crucially involved in severe cardiac pathological conditions. However, whether necroptosis contributes to age‐related intolerance ischemia/reperfusion (I/R) injury remains elusive. In addition, metformin as a potential anti‐aging related drug, how it interacts with myocardial not yet clear. Male C57BL/6 mice at 3–4‐ (young) and 22–24 months of age (aged) RIPK3‐deficient ( Ripk 3 −/− ) were used investigate aging‐related I/R vivo. Metformin (125 μg/kg, i.p.),...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew polymers with large and stable second-order nonlinear optical effectsMai Chen, Luping Yu, Larry R. Dalton, Yongqiang Shi, William H. SteierCite this: Macromolecules 1991, 24, 19, 5421–5428Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/ma00019a033https://doi.org/10.1021/ma00019a033research-articleACS PublicationsRequest reuse...

The photoinduced refractive index change of polyester with disperse red side groups was studied at several different wavelengths. This material exhibits a large (0.3 633 nm) and in addition when poled has sizable second-order nonlinear optical effect. monitored over 1000 h long-term stability demonstrated. Based on these results, method using only photomasks to define channel waveguides other patterns such polymers suggested experimentally may have wide applications integrated systems or...

We tested the hypothesis that high-conductance calciumactivated potassium (K_Ca) channel is involved in cardioprotection of preconditioning with ischemic insults. In isolated perfused rat heart subjected to ischemia/reperfusion, effects (IPC) on infarct size and lactate dehydrogenase (LDH) release were abolished by 1 μM paxilline (Pax), an inhibitor K_Ca channel, administered 30 min before, but not during, ischemia. ventricular myocytes metabolic inhibition anoxia (MI/A),...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLadder polymers: recent developments in syntheses, characterization, and potential applications as electronic optical materialsLuping Yu, Mai Chen, Larry R. DaltonCite this: Chem. Mater. 1990, 2, 6, 649–659Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://doi.org/10.1021/cm00012a013Request reuse permissions Article Views1135Altmetric-Citations121LEARN ABOUT THESE...

Background/purpose: Topography of the skin surface is a mirror functional status. Therefore, its evaluation great interest for dermatological research. In present study, new optical measuring system was applied to evaluate human topography in vivo and non‐invasively, order determine elastotic mimic wrinkles dependent on age, body site therapy. Methods: The measurements were performed back ( n =5), flexor forearm =14) volunteers different age groups face women =4) participating an...

To test the hypothesis that estrogen confers cardioprotection by suppressing expression of β-adrenoceptor (β-AR), we first correlated infarct size in response to ischemic insult and β-AR stimulation with β₁-AR sham, ovariectomized (Ovx) replaced (Ovx + E₂) rats. When is being activated during ischemia, was significantly greater Ovx than sham E₂ There a negative correlation between level as revealed Western blotting supported binding analysis. Incubation...

Background: Cardiac autophagic flux is impaired during myocardial ischemia/reperfusion (MI/R). Impaired may exacerbate MI/R injury. Charged multivesicular body protein 2B (CHMP2B) a subunit of the endosomal sorting complex required for transport (ESCRT-III) that autophagy. However, reverse role CHMP2B accumulation in autophagy and injury has not been established. The objective this article to elucidate roles AMP-activated kinase (AMPK)/atrogin-1 pathways inhibiting ischemia–reperfusion...

Remifentanil preconditioning (RPC) reduces the infarct size in anesthetized rat hearts, and this effect seems to be mediated by all three types of opioid receptors (ORs). Because there is evidence only kappa- delta- but not mu-ORs heart, authors investigated whether RPC confers cardioprotection via cardiac delta-OR as well extracardiac mu-OR agonist activity. The also involvement signaling mechanisms, namely protein kinase C mitochondrial adenosine triphosphate-sensitive potassium (KATP)...

A nonlinear optical polyester with disperse red side groups exhibited a stable photoinduced birefringence, from 0.14 at 850 nm to 0.21 633 nm, after exposure linearly polarized short-wavelength visible or ultraviolet light. Thin-film wave plates, birefringent diffraction gratings and waveguides were written in this polymer using photoexposure. Thin- film plates of <1 μm thickness showed ≳π/4 phase delay good temporal stability. 9:1 efficiency ratio the two polarization eigenmodes was...

Studies from our lab have shown that decreasing myocardial G protein-coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after infarction. Since GRK2 appears to also act as a pro-death in myocytes, we investigated the effect of cardiomyocyte-specific ablation on acute response cardiac ischemia/reperfusion (I/R) injury. To do this utilized two independent lines knockout (KO) mice where gene was deleted only cardiomyocytes either constitutively at...

Reactive aldehydes can initiate protein oxidative damage which may contribute to heart senescence. Sirtuin 1 (SIRT1) is considered be a potential interventional target for I/R injury management in the elderly. We hypothesized that aldehyde mediated carbonyl stress increases susceptibility of aged hearts ischemia/reperfusion (I/R) injury, and elucidate underlying mechanisms with focus on SIRT1. Male C57BL/6 young (4-6 mo) (22-24 mice were subjected myocardial I/R. Cardiac dehydrogenase...

Spatial control over supramolecular self-assembly prevails in living system, yet remains difficult to replicate synthetic scenarios. Here, on the basis of a hydrazone formation-mediated hydrogelation access patterning hydrogels is demonstrated via light-triggered catalysis strategy. A photoacid generator that can produce protons aqueous solutions upon irradiation employed. The generated lead drop pH around three units (initial 7.0), effectively accelerating formation and gelators. Because...

To assess the impact of anemia severity during antiretroviral therapy (ART) on in-hospital mortality among persons living with HIV. We conducted a retrospective cohort study hospitalized HIV at Fourth People's Hospital Nanning, Guangxi, China, from 2018 to 2020. Kaplan-Meier analysis was used calculate cumulative rates. The Cox proportional hazards model, 1:1:1 propensity score matching (PSM), and three-group inverse probability treatment weighting (IPTW) were in A total 2,217 included, whom...

A new thermosetting second-order nonlinear optical polyurethane polymer with disperse red 19 pendant groups was studied by second-harmonic generation and electro-optic modulation methods. The can be crosslinked thermal curing during electric field poling. coefficient r13 measured a Mach–Zehnder interferometer ranged from 5 pm/V at 800 nm to 13 633 nm. poling showed no significant decay of the nonlinearity room temperature for thousands hours. long-term stability dipole alignment an elevated...

Deacetylasperulosidic acid (DAA) is a major phytochemical constituent of Morinda citrifolia (noni) fruit. Noni juice has demonstrated antioxidant activity in vivo and human trials. To evaluate the role DAA this activity, Wistar rats were fed 0 (control group), 15, 30, or 60 mg/kg body weight per day for 7 days. Afterwards, serum malondialdehyde concentration superoxide dismutase glutathione peroxidase activities measured compared among groups. A dose-dependent reduction was evident as well...

Abstract Heme oxygenase (HO) activity in tissue adjacent to an intracerebral hematoma may modulate cellular vulnerability heme‐mediated oxidative injury. Although HO‐1 is induced after experimental hemorrhage (ICH), the time course of this induction, its effect on HO activity, and association with injury markers has not been defined. We therefore quantified expression, heme content, protein carbonylation for 8 days injection autologous blood into mouse striatum. Increased striatal was...

The cardiovascular profile of the apelin makes it a promising therapeutic target for heart failure and ischemic disease. However, remains unknown whether affect clinical outcome patients with ST elevation myocardial infarction (STEMI) received percutaneous coronary intervention (PCI). We enrolled total 120 acute STEMI who underwent primary PCI. Serum was detected. After PCI procedure, all were followed 12 months. follow-up end-point occurrence major adverse event (MACE). Lower serum levels...

The effect of preconditioning with U50,488 H (UP), a selective kappa‐opioid receptor ( κ ‐OR) agonist, on infarct size and intracellular Ca 2+ ([Ca ] i ) in the heart subjected to ischaemic insults were studied evaluated. administered intravenously reduced 18–48 h after administration isolated hearts regional ischaemia/reperfusion (I/R). was dose dependent. A peak reached at 10 mg kg −1 24 administration. abolished by nor‐binaltorphimine (nor‐BNI), ‐OR antagonist, indicating mediated....

The fast, contact-free and highly precise shape measurement of technical objects is key importance in the scientific- technological area as well practical technology. application areas contact- free surface extend across widely different areas, e.g., automation production processes, inspection components microsystem technology or fast 3D in-vivo human skin surfaces cosmetics medical This paper describes methodological possibilities applications for optical measurements using...