A5100621265- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Cardiac Ischemia and Reperfusion
- Psoriasis: Treatment and Pathogenesis
- Cardiac Structural Anomalies and Repair
- Nitric Oxide and Endothelin Effects
- Advanced MRI Techniques and Applications
- Mycobacterium research and diagnosis
- Pediatric Urology and Nephrology Studies
- Cell death mechanisms and regulation
- Coronary Artery Anomalies
- Heart Rate Variability and Autonomic Control
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tuberculosis Research and Epidemiology
- Antiplatelet Therapy and Cardiovascular Diseases
- Eicosanoids and Hypertension Pharmacology
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Immunology Research
- Traumatic Brain Injury and Neurovascular Disturbances
Capital Medical University
2012-2025
Beijing Tian Tan Hospital
2017-2025
National Clinical Research Center for Digestive Diseases
2021-2025
Union Hospital
2025
Jilin University
2024-2025
Beijing Chao-Yang Hospital
2024
China Rehabilitation Research Center
2024
Union Hospital
2024
Beijing Hospital of Traditional Chinese Medicine
2015-2023
Beijing YouAn Hospital
2015-2023
Fluoroquinolones and second-line injectable drugs are the backbone of treatment regimens for multidrug-resistant tuberculosis, resistance to these defines extensively drug-resistant tuberculosis. We assessed accuracy an automated, cartridge-based molecular assay detection, directly from sputum specimens, Mycobacterium tuberculosis with fluoroquinolones, aminoglycosides, isoniazid.
The flavonoid astilbin is the major active component extracted from rhizome of Smilax glabra, which has been widely used in China to treat inflammatory and autoimmune diseases, Psoriasis a common chronic disease T helper 17 (Th17) cells play an important role, provoking inflammation. We employed imiquimod (IMQ)-induced psoriasis-like mouse model investigate effect Mice were administered 25 50 mg/kg astilbin. Inflammation lesions was assessed by histology, circulating levels flow cytometry...
The forkhead box transcription factor A2 (FOXA2) is a and plays key role in embryonic development, metabolism homeostasis tumor cell proliferation; however, its regulatory potential CRC not fully understood. Here, it found that FOXA2 expression markedly up-regulated samples of patients as compared with the normal tissues, which closely associated worse survival CRC. Notably, positive correlation between nuclear erythroid 2-related 2 (Nrf2)/glutathione peroxidase 4 (GPX4) gene observed...
Background: As a major food crop, maize is highly susceptible to pathogenic bacteria, which greatly reduces its yield and quality. Metabolomics reveals physiological biochemical changes in organisms aids analyzing metabolic caused by various factors. Methods: This study utilized metabolomics examine maize’s after NCLB infestation, aiming uncover related pathways potential biomarkers. The metabolite measurements were performed during the silking stage. Results: PCA showed an obvious...
Background This study examines the anatomical characteristics of mitral isthmus (MI) and its spatial relationship with esophagus in patients undergoing atrial fibrillation ablation, using cardiovascular computed tomographic angiography (CTA). Understanding this is crucial to minimize risk esophageal injuries during ablation procedures. Methods The investigation included 300 participants, divided into 200 subjects experimental group 100 control group. Detailed CTA scans were used assess MI's...
Background: Collateral circulation provides compensatory flow to ischemic brain regions in acute large vessel occlusion (LVO), which had been associated with better outcomes after endovascular treatment (EVT). Aims: We aimed reveal the pre-EVT collateral status and its associations EVT, patients LVO different etiologies. Methods: Based on a prospective, multicenter registry, we analyzed acute, intracranial anterior-circulation due artery atherosclerosis (LAA) cardioembolism (CE), who...
Objective To develop and validate a nomogram based on systemic inflammation response index (SIRI) clinical risk factors to predict short-term prognosis in very elderly patients with hypertensive intracerebral hemorrhage (HICH). Methods A total of 324 HICH from January 2017 June 2024 were retrospectively enrolled randomly divided into two cohorts for training ( n = 227) validation 97) according the ratio 7:3. Independent predictors poor analyzed using univariate multivariate logistic...
Abstract Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis. However, whether increased Omi/HtrA2 within mitochondria itself influences myocardial survival in vivo unknown. aim to observe the effects mitochondria-specific, not cytoplasmic, on and cardiac function. Transgenic mice overexpressing cardiac-specific mitochondrial were generated they...
The functional assessment of a hemodynamic significant stenosis base on blood pressure variation has been applied for evaluation the myocardial ischemic event. This shows great potential improving accuracy classification severity carotid stenosis. To explore value grading using gradient (PG)-we had reconstructed patient-specific geometries based MRI images-computational fluid dynamics were performed to analyze PG in their stenotic arteries. Doppler ultrasound image data and corresponding 19...
Coronary arterial stenoses, particularly serial stenoses in a single branch, are responsible for complex hemodynamic properties of the coronary trees, and uncertain prognosis invasive intervention. Critical information blood flow redistribution stenotic segments is required adequate treatment planning. Therefore, this study, an image based non-invasive functional assessment performed to investigate significances stenoses. Twenty patient-specific trees with different combinations were...
In order to investigate the role of nitrative stress in vascular endothelial injury hyperhomocysteinemia (HHcy), thirty healthy adult female Wistar rats were randomly divided into three groups: control, model, and with FeTMPyP (peroxynitrite scavenger) treatment. The endothelium-dependent dilatation thoracic aorta vitro was determined by response acetylcholine (ACh). histological changes endothelium assessed HE staining scanning electron microscopy (SEM). expression 3-nitrotyrosine (NT)...
Mitochondrial homeostasis is a key process involved in cellular destiny and organic function. When mitochondrial status abnormal, it will become “death motor.” Impaired mitochondria lead to the release of cytochrome c, then trigger mitochondria-induced caspase activation. Omi/HtrA2, serine protease, locates involves homeostasis. Increased Omi/HtrA2 observed aging cardiac tissues, whether this has effects on not been reported. In study, natural Sprague-Dawley rats (22 months) were used. We...
Cerebrovascular events are frequently associated with hemodynamic disturbance caused by internal carotid artery (ICA) stenosis. It is challenging to determine the ischemia-related stenosis during intervention only using digital subtracted angiography (DSA). Inspired performance of well-established FFRct technique in assessment significant coronary stenosis, we introduced a pressure-based arterial functional (CAFA) index generated from computational fluid dynamic (CFD) simulation DSA data,...
The age-related loss of anti-oxidant defense reduces recovery from myocardial ischemia/reperfusion injury (MI/R) in aged people. Our previous data showed that inactivation thioredoxin (Trx) was involved enhanced aging MI/R injury. Thioredoxin reductase (TrxR), the enzyme known to regulate Trx, is less efficient with age. aim current study determine why TrxR activity reduced and whether contributed Both Trx were decreased heart, this difference further amplified after MI/R. However, did not...
Declined vasorelaxation function in aging resistance arteries is responsible for aging-related multiple organ dysfunctions. The aim of the present study to explore role peroxynitrite (ONOO-) arterial dysfunction and possible mechanism. In study, young (3–4 months olds) (20 male SD rats were randomized receive vehicle (Saline) or FeTMPyP (ONOO- scavenger) 2 weeks. was determined vitro; NOx level tested by a colorimetric assay; expression nitrotyrosine (NT), soluble Guanylate Cyclase (sGC),...
Psoriasis (PA) is a chronic autoimmune disease of the skin that adversely affects patients' quality life. Yangxue Jiedu Fang (YXJD) has been used for decades to treat psoriasis in China. However, its antipsoriatic mechanisms are still poorly understood. In this study, we explored effects YXJD on angiogenesis and apoptosis microvessels PA, underlying HUVEC cells transfected by Survivin overexpression plasmid mouse model imiquimod-induced relationship between VEGF (vascular endothelial growth...
Abstract Background Myocardial fibrosis is a key pathological factor for the occurrence of ventricular arrhythmias in hypertrophic obstructive cardiomyopathy (HOCM). Case summary This case series reports on two patients diagnosed with HOCM who underwent 18F-fibroblast activation protein inhibitor (FAPI) positron-emission tomography/computed tomography imaging and Morrow myotomy procedure. The collected myocardial tissue was examined histopathologically. Both exhibited intense heterogeneous...
Objectives: Fractional flow reserve (FFR) accurately predicts the degree of stenosis and is now widely used to identify clinically significant severe coronary artery lesions. In current study, we utilized a similar indicator, fractional (FF), determine hemodynamic impact symptomatic intracranial atherosclerotic (ICAS) assess correlation FF with severity collateral circulation.Methods: Patients ICAS (70–99% stenosis) confirmed on digital subtraction angiography (DSA) were consecutively...
The aim of this study was to evaluate the accuracy a new blood pressure (BP) measurement method (Pulse method).This enrolled 45 patients for selective percutaneous coronary intervention (PCI) via right radial artery. A BP device using either oscillometric (Microlife 3AC1-1) or Pulse method(RG-BP11)was used. At beginning each PCI, intra-radial measured before Microlife as its own reference, respectively. end again with order and reversed. differences between (BPi-M) (BPi-P) on SBP, DBP mean...
To study the association of single nucleotide polymorphism (SNP) rs2076185 in chromosome 6p24.1 with premature coronary artery diseases (PCAD) Chinese Han population.A total 1382 patients were divided into PCAD group and control based on their arteriography (CAG) results. Their SNP analyzed by mass-spectrometry. allele genotype frequency Hardy-Weinberg equilibrium calculated for assessment. Logistic regression was employed to remove confounding factors correlate PCAD.The frequencies (P >...