A5038354501- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
Chinese University of Hong Kong
2023-2025
Background: Collateral circulation provides compensatory flow to ischemic brain regions in acute large vessel occlusion (LVO), which had been associated with better outcomes after endovascular treatment (EVT). Aims: We aimed reveal the pre-EVT collateral status and its associations EVT, patients LVO different etiologies. Methods: Based on a prospective, multicenter registry, we analyzed acute, intracranial anterior-circulation due artery atherosclerosis (LAA) cardioembolism (CE), who...
There may be different mechanisms underlying internal (IBZ) and cortical (CBZ) borderzone infarcts in intracranial atherosclerotic stenosis. In 84 patients with symptomatic, 50-99% stenosis of M1 middle cerebral artery (MCA-M1) acute diffusion-weighted imaging, we classified the infarct patterns as isolated IBZ (n = 37), CBZ 31), IBZ+CBZ 16) infarcts. CT angiography-based computational fluid dynamics models were constructed to quantify translesional, post-stenotic pre-stenotic pressure ratio...
Introduction: Cerebral small vessel disease (CSVD) commonly exists in patients with symptomatic intracranial atherosclerotic (sICAD). We aimed to investigate the associations of hemodynamic features sICAD lesions imaging markers and overall burden CSVD. Patients methods: anterior-circulation (50%–99% stenosis) were analyzed this cross-sectional study. Hemodynamic a lesion quantified by translesional pressure ratio (PR = Pressure post-stenotic /Pressure pre-stenotic ) wall shear stress (WSSR...
We investigated the association between cerebral small vessel disease (CSVD) and ipsilateral leptomeningeal collateral (LMC) status in patients with symptomatic intracranial atherosclerotic stenosis (sICAS). In 108 50–99% internal carotid artery or M1 middle stenosis, 4 CSVD imaging markers (lacunes, microbleeds, enlarged perivascular spaces [EPVSs], white matter hyperintensities [WMHs]) were assessed MRI. Score of 0 1 was assigned to each marker added up as a summary score (ranging 0–4)...