A5049838202- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Cerebral Venous Sinus Thrombosis
- Moyamoya disease diagnosis and treatment
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- CNS Lymphoma Diagnosis and Treatment
- MRI in cancer diagnosis
- Peripheral Artery Disease Management
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Complications and Syndromes
- Brain Tumor Detection and Classification
- Cardiac Imaging and Diagnostics
- Brain Metastases and Treatment
- Pituitary Gland Disorders and Treatments
- Medical Imaging and Analysis
- Protease and Inhibitor Mechanisms
- Neurological Disease Mechanisms and Treatments
- Spinal Fractures and Fixation Techniques
Capital Medical University
2018-2025
Beijing Tian Tan Hospital
2018-2025
National Clinical Research Center for Digestive Diseases
2018-2023
Chinese Institute for Brain Research
2018-2020
Background: Collateral circulation provides compensatory flow to ischemic brain regions in acute large vessel occlusion (LVO), which had been associated with better outcomes after endovascular treatment (EVT). Aims: We aimed reveal the pre-EVT collateral status and its associations EVT, patients LVO different etiologies. Methods: Based on a prospective, multicenter registry, we analyzed acute, intracranial anterior-circulation due artery atherosclerosis (LAA) cardioembolism (CE), who...
Background To investigate whether collateral status could modify the associations between post-thrombectomy blood pressure (BP) measures and outcomes. Methods Results Patients with anterior-circulation large-vessel-occlusion successfully recanalized in a multicenter endovascular thrombectomy registry were enrolled. Pretreatment was graded dichotomized (good/poor) angiography. Maximum, minimum, mean systolic BP (SBP) variability (assessed by SD, coefficient of variation) during initial 24...
To evaluate the diagnostic performance of T2 mapping in differentiating WHO grade II glioma from high-grade (HGG).We conducted a single-center, retrospective study. Confirmed diffuse (WHO II-IV) patients who underwent post-contrast T1-weighted imaging, T2-weighted and were included. All diagnoses based on histological molecular tests. Seventy-five percent cases subsampled to generate receiver operating characteristic (ROC) curves areas under curve (AUC), while remaining used test accuracy...
Background and Purpose: We aimed to evaluate the impact of cortical microinfarcts (CMIs) on functional outcome after endovascular treatment in patients with acute ischemic stroke. Methods: In a multicenter registration study for RESCUE-RE (a Critical Care Acute Ischemic Stroke After Recanalization), eligible large vessel occlusion stroke receiving treatment, who had undergone 3T magnetic resonance imaging admission or within 24 hours were analyzed. evaluated presence numbers CMIs assessment...
Background and purpose In-stent restenosis (ISR) is one of the long-term adverse outcomes endovascular angioplasty stenting for symptomatic intracranial arterial stenosis. In this study, we try to evaluate safety efficacy treatment ISR. Methods We retrospectively collected patients with ISR who underwent from June 2012 August 2019 at a high-volume stroke center. Successful recanalization was defined as ≤30% residual Stroke, myocardial infarction, death after within 30 days were used...
Background Identification of futile recanalisation following endovascular therapy (EVT) in patients with acute ischaemic stroke is both crucial and challenging. Here, we present a novel risk stratification system based on hybrid machine learning method for predicting recanalisation. Methods Hybrid models were developed to address six clinical scenarios within the EVT perioperative management workflow. These trained prospective database using feature selection technique predict EVT. The...
The recent randomized controlled trials studying intracranial atherosclerotic stenosis (ICAS) have used digital subtraction angiography (DSA) to quantify and enroll patients. However, some disadvantages of DSA such as invasive features, contrast agent overuse, X-ray radiation overexposure, were not considered in these studies. This study aimed explore whether computed tomography (CTA) with semi-automatic analysis could be an alternative method quantifying the absolute stenotic degree clinical trials.
Objective: To explore the cerebral hemodynamic changes after revascularization in patients with hemorrhagic moyamoya disease (MMD). Materials and Methods: We retrospectively included 57 MMD a high-volume stroke center from January 2016 to December 2018. All subjects were evaluated whole-brain CT perfusion (CTP) before surgical revascularization. Absolute relative CTP values regions of cortical middle artery territory (CMT) deep brain area (DBA) hemispheres measured. Differences between pre-...
Objective: This study aimed to investigate the association between cognitive impairment and cerebral haemodynamic changes in patients with chronic vertebra-basilar (VB) stenosis. Methods: Patients severe posterior circulation VB stenosis infarction or a history of for more than 2 weeks from January 2014 2015 were enrolled (n = 96). They divided into three groups, namely, computed tomography perfusion (CTP) normal group, CTP compensated decompensated group. Cognitive function was assessed...
Background and Purpose: Intraluminal thrombus (ILT) is an emerging imaging marker in acute ischemic stroke. We aimed to investigate the association of ILT with outcomes large vessel occlusion (LVO) patients receiving endovascular treatment. Methods: Acute LVO stroke who underwent treatment within 24 hours, a prospective, nationwide registry were enrolled. Pretreatment digital subtraction angiography was reviewed for presence ILT. The primary outcome 90-day functional dependence (modified...
Collateral flow is associated with clinical outcomes for patients Moyamoya disease and served as a parameter patient selection of therapeutic strategies. Therefore, we explored whether noninvasive imaging modality, computed tomography perfusion (CTP) source images (CTP-Sis), could be used to identify the presence intensity collateral using digital subtraction angiography (DSA) gold standard flow.CTP-Sis DSA were performed 24 unilateral disease. A grading system was developed based on...
Objective: We performed this study to evaluate the hemodynamic changes over time after successful endovascular recanalization in patients with symptomatic chronic intracranial artery occlusion (CIAO). Materials and Methods: included 20 CIAO a high-volume stroke center from June 2014 2019. All subjects were evaluated CT perfusion (CTP) studies before recanalization. The relative cerebral blood flows (rCBFs) perforating territory (PAT) cortical (CAT) of occluded arteries compared categorized...
The aim of this study was to find out the relationship between serum biomarkers and cerebral collateral status in acute ischemic stroke with large artery atherosclerosis.We enrolled patients due atherosclerosis within 7 days symptom onset, age 18-80 years, from August 2016 December 2017. Twelve representing different pathophysiological mechanisms were tested after admission. Whole-brain perfusion combined multiphase computed tomography angiography performed assess structure...
We investigated the relationship between basilar artery (BA) atherosclerotic stenosis features and vertebral (VA) explored whether BA are associated with perforator stroke after stenting.Patients who underwent HRMRI DSA were recruited. Patients divided into proximal middle-or-distal groups, then subgroup analyses performed based on they had VA stenosis. plaque evaluated by HRMRI. Artery was measured DSA. The incidence of stenting recorded, potential association analyzed.One hundred...
Introduction: Vertebrobasilar junction (VBJ) stenosis is a challenge in endovascular treatment due to structural variants and complexities. The role of high-resolution magnetic resonance imaging (HRMRI) for patients with severe VBJ uncertain. Case Report: Four symptomatic underwent HRMRI the vessel wall before treatment. In 3 patients, could not be visualized on luminal imaging. One them had hypoplastic artery 2 stenotic arteries HRMRI. showed an negative remodeling patient vertebral artery....
Objective To evaluate the correlation between cerebral blood flow perfusion and memory impairment in patients with severe stenosis of vertebral basilar artery(VBA). Methods 62 cases VBA diagnosed by digital subtraction angiography(DSA) Beijing Tiantan Hospital from September 2016 to March 2017 were enrolled.Mental State Examination (MMSE), Clinical Memory Scale(CMS) test CT perfusion(CTP) was performed.All divided into normal group(n=24, including 1 excellent case, 6 above cases, 14...
Objective To study the imaging features of lymphocytic hypophysitis in order to improve accuracy diagnosis disease. Methods Imaging findings 9 patients with admitted Neurosurgery Department Beijing Tiantan Hospital, Capital Medical University from January 2010 December 2016 were retrospectively reviewed. All underwent laboratory examinations related pituitary function. Except for 2 cases slight increase prolactin, levels other hormones normal. examined pre-contrast and post-contrast...
Objective To analyze the radiological features of idiopathic pediatric meningiomas and explore their relationships with pathological grading,misdiagnoses,and blood loss during surgery.Methods We retrospectively reviewed 29 cases pathologically confirmed pre-operative magnetic resonance imaging in Beijing Tiantan Hospital from November 2014 to July 2018.We assessed surgery. Results Among cases,7 intraparenchymal meningiomas,5 extraparenchymal meningiomas,4 ventricular meningiomas,and 1...