A5051461290- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Cerebral Venous Sinus Thrombosis
- Healthcare Systems and Practices
- Neurosurgical Procedures and Complications
- Spinal Hematomas and Complications
- EEG and Brain-Computer Interfaces
- Cardiovascular Health and Disease Prevention
- Peripheral Artery Disease Management
- Cerebrovascular and genetic disorders
- Atrial Fibrillation Management and Outcomes
- Optical Imaging and Spectroscopy Techniques
- Coronary Interventions and Diagnostics
Beijing Tian Tan Hospital
2015-2025
Capital Medical University
2015-2025
National Clinical Research Center for Digestive Diseases
2018-2025
National Clinical Research
2021
Chinese Institute for Brain Research
2018
China is one of the countries with highest burden stroke. Implementing multidimensional management guidelines will help clinicians practise evidence-based care, improve patient outcomes and alleviate societal burdens. This update 2019 edition provide latest comprehensive recommendations for diagnosis treatment ischaemic cerebrovascular diseases.
<b><i>Background:</i></b> Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) is a significant cause of morbidity and mortality. While it important to detect early signs DCI, patients with high risk DCI are difficult identify, the potential factors uncertain. This study aimed identify independent clarify their clinical impact on outcome disease course. <b><i>Methods:</i></b> For this nationwide, multicenter,...
Abstract Background Neurovascular coupling (NVC) refers to the process of aligning cerebral blood flow with neuronal metabolic demand. This study explores potential contralateral NVC—linking neural electrical activity on stroke side velocity (CBFV) contralesional side—as a marker physiological function brain. Our aim was examine association between NVC and neurological outcomes in patients ischemic following endovascular thrombectomy. Methods We concurrently recorded CBFVs middle arteries...
Background: Collateral circulation provides compensatory flow to ischemic brain regions in acute large vessel occlusion (LVO), which had been associated with better outcomes after endovascular treatment (EVT). Aims: We aimed reveal the pre-EVT collateral status and its associations EVT, patients LVO different etiologies. Methods: Based on a prospective, multicenter registry, we analyzed acute, intracranial anterior-circulation due artery atherosclerosis (LAA) cardioembolism (CE), who...
BACKGROUND: Endovascular therapy (EVT) has been proved to benefit patients with acute large vessel occlusion (LVO) infarcts, but it is unknown whether the isaffected by interhospital-transfer status. We investigated efficacy of EVT according status in such patients. METHODS: This was a secondary analysis ANGEL-ASPECT trial. Patients anterior-circulation LVO and defined ASPECTS 3-5 or infarct core volume 70-100mL, were enrolled from forty-six centers across China randomized (1:1) receive...
BACKGROUND: Endovascular therapy (EVT) has been proven effective for patients with acute ischemic stroke large infarcts. This study aimed to explore the impact of clinical severity on efficacy EVT in such patients. METHODS: was a post hoc analysis ANGEL-ASPECT trial (Endovascular Therapy Acute Anterior Circulation Large Vessel Occlusive Patients With Infarct Core), randomized controlled that enrolled from 46 centers across China between October 2, 2020, and May 18, 2022. These had infarcts...
Background The relationship between post-endovascular thrombectomy (EVT) blood pressure (BP) and outcomes in patients with acute ischemic stroke (AIS) remains contentious. We aimed to explore whether this association differs different cerebral perfusion statuses post-EVT. Methods In a multicenter observational study of AIS large vessel occlusion who underwent EVT, we enrolled those accepted CT (CTP) imaging within 24 hours recorded post-EVT systolic (SBP) diastolic BP. Patients were...
Intracranial atherosclerosis burden is an arising key index for the risk and prognosis Atherosclerosis Stenosis (ICAS). The present study estimated one-year patients of symptomatic ICAS with different degrees intracranial (ICASB) identified whether category multiple single acute infarction was associated burden. A total 2864 consecutive patients, from 22 hospitals across China, who experienced cerebral ischemia <7 days after onset symptoms were evaluated. All underwent magnetic resonance...
Background and Purpose: We aimed to evaluate the impact of cortical microinfarcts (CMIs) on functional outcome after endovascular treatment in patients with acute ischemic stroke. Methods: In a multicenter registration study for RESCUE-RE (a Critical Care Acute Ischemic Stroke After Recanalization), eligible large vessel occlusion stroke receiving treatment, who had undergone 3T magnetic resonance imaging admission or within 24 hours were analyzed. evaluated presence numbers CMIs assessment...
BackgroundEndovascular therapy (EVT) was demonstrated effective in acute large vessel occlusion (LVO) with infarction. Revealing subgroups of patients who would or not benefit from EVT will further inform patient selection for EVT.MethodsThis post-hoc analysis the ANGEL-ASPECT trial, a randomised controlled trial 456 adult anterior-circulation LVO and infarction, defined by ASPECTS 3–5 infarct core volume 70–100 mL, enrolled 46 centres across China, between October 2, 2020 May 18, 2022....
Intraplaque hemorrhage is a widely known factor facilitating plaque instability. Neovascularization of can be regarded as compensatory response to the blood supply in deep intimal and medial areas artery. Due physiological function, deformation carotid atherosclerotic would happen under action pressure flow. Neovessels are subject mechanical loading likely undergo deformation. The rupture neovessels may deteriorate instability plaque. This study focuses on local environments around...
The role of serum uric acid (SUA) in affecting outcomes after endovascular treatment (EVT) patients with ischemic stroke remains unclear. This study investigated the association SUA acute large vessel occlusion (LVO) who had received EVT.Patients LVO underwent EVT within 24 hours were enrolled from a prospective, nationwide registry study. Baseline characteristics and level collected. primary outcome was an excellent 90-day functional [modified Rankin Scale (mRS) score 0-1]. Secondary...
Leukoaraiosis (LA) is frequently found in ischemic stroke patients, especially when those patients have intracranial atherosclerosis (ICAS). However, previous studies regarding an association of LA with cerebral large artery showed conflicting results, and the relationship ICAS uncertain. This study aimed to explore between Chinese ischemia. Data were derived from Intracranial Atherosclerosis (CICAS) study. Patients diagnosed or transient attack (TIA) within 7 days symptom onset included....
The China Antihypertensive Trial in Acute Ischemic Stroke II (CATIS-2) suggests that early antihypertensive treatment did not reduce the risk of dependency or death acute ischemic stroke (AIS), compared with delayed treatment. Single subcortical infarction (SSI) is an important subtype, and association timing clinical outcomes unclear.
Background and Purpose: Intraluminal thrombus (ILT) is an emerging imaging marker in acute ischemic stroke. We aimed to investigate the association of ILT with outcomes large vessel occlusion (LVO) patients receiving endovascular treatment. Methods: Acute LVO stroke who underwent treatment within 24 hours, a prospective, nationwide registry were enrolled. Pretreatment digital subtraction angiography was reviewed for presence ILT. The primary outcome 90-day functional dependence (modified...
The association of preceding antithrombotic therapy with outcomes patients intracerebral hemorrhage (ICH) has not been well clarified. We investigated the characteristics and associations prior (oral anticoagulants, antiplatelet or both) in in-hospital ICH. Data were derived from Chinese Stroke Center Alliance (CSCA) database. Enrolled categorized by different types therapy: (APT), oral coagulants (OAs), both OAs APT use no-antithrombotic (no-ATT). Among 85705 enrolled, 4969 (5.8%), 720...
Background and Purpose: Quantitative electroencephalogram (QEEG) parameters have been previously utilized in prognosis following acute ischemic stroke (AIS). However, the use interpretation of QEEG remain scarce endovascular treatment (EVT) AIS.Methods: AIS patients were prospectively enrolled EVT, 24-hour EEG monitoring was conducted. Global delta/alpha ratio (DAR), (delta + theta)/(alpha beta) (DTABR), relative band power analyzed. Primary outcome a poor (modified Rankin Scale ≥4 at 90-day...
Personalized blood pressure (BP) management for patients with acute ischemic stroke after successful endovascular thrombectomy lacks evidence. We aimed to investigate whether the deviation of BP from cerebral autoregulation limits is associated worse outcomes.
Abstract Background Personalized blood pressure (BP) management for acute ischemic stroke patients after successful recanalization lacks evidence. Our study aimed to investigate whether the deviation of BP from cerebral autoregulation (CA) limits, either in duration or burden, is associated with worse outcomes. Methods We prospectively enrolled large anterior circulation artery occlusive who had achieved (mTICI 2b-3). CA was determined by measuring mean velocity index (Mx) using transcranial...
Background: Task-shifting rehabilitative care from rehabilitation therapists to physicians, nurses, and relatives may supplement the shortage of specialized personnel in China. However, it is unknown how this practice affects patient outcomes. This study examined association provider type with functional dependence mortality among patients acute ischemic stroke (AIS) Methods: Patients AIS hospitalized at participating China National Stroke Registry II hospitals were eligible if they had no...
Background and purpose: Spontaneous subarachnoid hemorrhage is a neurological emergency with high mortality disability. Hypertensive states are related to bad prognosis higher risk of rebleeding. However, the relationship between blood pressure onset time spontaneous its quite unknown.Methods: Data from Chinese Stroke Center Alliance database was reviewed. Patients were divided into 4 groups according status admission systolic pressure. Poor outcome regarded as in-hospital or withdrawal...