Zhiming Zhou
A5000546663- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinal and Optic Conditions
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Artery Disease Management
- Mitochondrial Function and Pathology
- Astronomy and Astrophysical Research
- MicroRNA in disease regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Diabetic Foot Ulcer Assessment and Management
- ATP Synthase and ATPases Research
- RNA modifications and cancer
- Nuclear Receptors and Signaling
- Chemokine receptors and signaling
- Coronary Interventions and Diagnostics
- T-cell and B-cell Immunology
- Enzyme Catalysis and Immobilization
- Neurogenesis and neuroplasticity mechanisms
Wannan Medical College
2016-2025
First Affiliated Hospital of Wannan Medical College
2016-2025
Guangdong Pharmaceutical University
2025
Nanjing University
2010-2024
Nanjing General Hospital of Nanjing Military Command
2010-2024
Huazhong University of Science and Technology
2005-2023
Macau University of Science and Technology
2018-2021
Zhejiang Institute of Freshwater Fisheries
2021
Central South University
2019
Third Xiangya Hospital
2019
The role of endovascular therapy for acute stroke with a large infarction has not been extensively studied in differing populations. Download PDF the Research Summary. We conducted multicenter, prospective, open-label, randomized trial China involving patients large-vessel occlusion anterior circulation and an Alberta Stroke Program Early Computed Tomography Score 3 to 5 (range, 0 10, lower values indicating larger infarction) or infarct-core volume 70 100 ml. Patients were randomly assigned...
<h3>Importance</h3> For patients with large vessel occlusion strokes, it is unknown whether endovascular treatment alone compared intravenous thrombolysis plus (standard treatment) can achieve similar functional outcomes. <h3>Objective</h3> To investigate thrombectomy noninferior to alteplase followed by for achieving independence at 90 days among stroke. <h3>Design, Setting, and Participants</h3> Multicenter, randomized, noninferiority trial conducted 33 stroke centers in China. Patients (n...
Data from trials investigating the effects and risks of endovascular thrombectomy for treatment stroke due to basilar-artery occlusion are limited.
<h3>Importance</h3> Several randomized clinical trials have recently established the safety and efficacy of endovascular treatment (EVT) acute ischemic stroke in anterior circulation. However, it remains uncertain whether patients with basilar artery occlusion (BAO) benefit from EVT. <h3>Objective</h3> To evaluate association between EVT outcomes BAO. <h3>Design, Setting, Participants</h3> This nonrandomized cohort study, for Acute Basilar Artery Occlusion Study (BASILAR) was a nationwide...
Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor, which reversibly inhibits platelet aggregation. It remains uncertain whether intravenous tirofiban effective to improve functional outcomes for patients with large vessel occlusion ischemic stroke undergoing endovascular thrombectomy.To assess the efficacy and adverse events before thrombectomy acute secondary occlusion.This investigator-initiated, randomized, double-blind, placebo-controlled trial was...
DL-3-n-butylphthalide (NBP) is a drug for treating acute ischemic stroke and may play neuroprotective role by acting on multiple active targets. The efficacy of NBP in patients with receiving reperfusion therapy remains unknown. To assess the safety intravenous thrombolysis and/or endovascular treatment. This multicenter, double-blind, placebo-controlled, parallel randomized clinical trial was conducted 59 centers China 90-day follow-up. Of 1236 stroke, 1216 18 years older diagnosed National...
Abstract Objective To assess whether intra-arterial tenecteplase administered after successful endovascular recanalisation improves outcomes in patients with acute arterial occlusion of the posterior circulation. Design Multicentre randomised controlled trial. Setting 31 hospitals China, 24 January 2023 to August 2023. Participants 208 (grade 2b50-3 on extended thrombolysis cerebral infarction scale) an V4 segment vertebral artery; proximal, middle, or distal basilar P1 artery: 104 were...
Background and Purpose: The benefit of endovascular treatment (EVT) for large vessel occlusion in clinical practice developing countries like China needs to be confirmed. aim the study was determine whether EVT acute ischemic stroke randomized trials could generalized Chinese population. Methods: We conducted a prospective registry at 111 centers China. Patients with caused by imaging-confirmed intracranial receiving were included. primary outcome functional independence 90 days defined as...
Nerve growth factor (NGF) has been proved with the potential of promoting neurogenesis in adult mammalians. This study was aimed to investigate effect intranasal (IN) NGF on striatal and functional recovery rats focal cerebral ischemia. Rats were subjected middle artery occlusion (MCAO) for 2 h, then reperfused. or vehicle intranasally administered 24 h after reperfusion, treatments continued 6 consecutive days there after. All animals injected 5-bromodeoxyuridine (BrdU) twice daily 5-7...
<b><i>Aims:</i></b> To evaluate the serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with Alzheimer's disease (AD), explore correlations between three cytokines relevant parameters. <b><i>Methods:</i></b> Serum concentrations IL-18, were measured by ELISA for 53 AD sex- age-matched healthy controls a community elderly individuals Shanghai suburb. <b><i>Results:</i></b> significantly higher than...
<b><i>Background and Objective:</i></b> Endovascular treatment (EVT) is proven to be safe effective for treating acute large vessel occlusion stroke (LVOS). The neutrophil-lymphocyte ratio (NLR) reflects systemic inflammation, which plays an important role in the process of ischemic stroke. This study aims explore relationship between NLR clinical outcomes LVOS patients undergoing EVT. <b><i>Methods:</i></b> Patients were selected from EVT...
Malignant brain edema (MBE) is a devastating complication in ischemic stroke. Data on MBE patients who have had mechanical thrombectomy (MT) are relatively scarce.To investigate the incidence, predictors, and clinical outcomes of after MT.We included 130 consecutive MT caused by anterior circulation large vessel occlusion stroke, treated with MT. was defined as midline shift ≥5 mm follow-up imaging within 72 hours Characteristics at admission details treatment were collected. The 90-day...
<b><i>Backgrounds and Purpose:</i></b> This study was aimed at investigating the outcomes predictors for poor functional outcome after endovascular treatment (EVT) in a large, mostly Asian population. <b><i>Methods:</i></b> Between January 2014 June 2016, acute stroke patients with anterior circulation occlusion EVT were retrospectively enrolled from 21 centers China. The main modified Rankin Scale (0-2 as independence, 3-6 poor) 90 days,...
Background and Purpose: A recent randomized controlled trial DIRECT-MT (Direct Intra-Arterial Thrombectomy to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals) compared the safety efficacy of mechanical thrombectomy (MT) versus combined intravenous thrombolysis (IVT) MT for acute large vessel occlusion. The current study utilized a prospective, nationwide registry validate results real-world practice setting. Methods: Subjects were selected...
Sex disparities in acute large vessel occlusion (LVO) following endovascular treatment (EVT) have been recently reported. However, there is uncertainty about the effect of sex differences on functional outcomes after EVT, particularly an Asian population. The present study aimed to compare clinical and safety between men women with anterior circulation LVO treated EVT.
<b><i>Background:</i></b> Hyperintense vessels (HVs) on fluid-attenuated inversion recovery (FLAIR) are frequently observed in acute ischemic stroke (AIS). The presence of HVs represents altered blood flow from collaterals distal to arterial occlusion or stenosis. This study aimed evaluate the prognostic value AIS. <b><i>Methods:</i></b> Fifty-four consecutive patients with middle cerebral artery were enrolled study. location and extent was...
In patients undergoing mechanical thrombectomy (MT), adjunctive antithrombotic might improve angiographic reperfusion, reduce the risk of distal emboli and reocclusion but possibly expose to a higher intracranial hemorrhage risk. This study evaluated safety efficacy combined MT plus eptifibatide for acute ischemic stroke. was propensity-matched analysis data from 2 prospective trials in Chinese populations: ANGEL-ACT trial (Endovascular Treatment Key Technique Emergency Workflow Improvement...
Aberrant alternative splicing and abnormal events (ASEs) in glioblastoma multiforme (GBM) remain largely elusive. The prognostic-associated ASEs GBM were identified summarized into 123 genes using LGG datasets from ASCancer Atlas TCGA. eleven (C2, COL3A1, CTSL, EIF3L, FKBP9, FN1, HPCAL1, HSPB1, IGFBP4, MANBA, PRKAR1B) screened to develop an prognostic risk score (ASRS) model through machine learning algorithms. was trained on the TCGA-GBM cohort validated with four external CGGA GEO,...
The outbreak of coronavirus disease 2019 (COVID-19) has presented serious threats to people's health and lives. Police officers are bravely fighting on the front lines epidemic. main purpose this study was assess prevalence severity psychological responses among police during COVID-19 pandemic find influencing factors in depression anxiety.A cross-sectional online questionnaire administered Wuhu through WeChat, data were collected between March 10 26, 2020. A total 3,561 questionnaires...
Two recently published JNIS commentaries 1 2 on eligibility criteria for the clinical trials patients with large core, acute ischemic stroke (AIS) vessel occlusion have caused some debate.Five were included. 1Our ongoing trial, ANGEL-ASPECT (NCT 04551664), which represents only core trial currently in Chinese population, was not included discussion.One issue of debate is addition CT perfusion (CTP)/ diffusion-weighted image magnetic resonance imaging (DWI-MRI) to inclusion criteria, SELECT-2...
BackgroundEndovascular therapy (EVT) was demonstrated effective in acute large vessel occlusion (LVO) with infarction. Revealing subgroups of patients who would or not benefit from EVT will further inform patient selection for EVT.MethodsThis post-hoc analysis the ANGEL-ASPECT trial, a randomised controlled trial 456 adult anterior-circulation LVO and infarction, defined by ASPECTS 3–5 infarct core volume 70–100 mL, enrolled 46 centres across China, between October 2, 2020 May 18, 2022....