A5100391707- Acute Ischemic Stroke Management
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Valve Diseases and Treatments
- Wnt/β-catenin signaling in development and cancer
- Stroke Rehabilitation and Recovery
- Advanced Glycation End Products research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cancer-related gene regulation
- Erythropoietin and Anemia Treatment
- Cardiac Arrest and Resuscitation
- Intracerebral and Subarachnoid Hemorrhage Research
- Trauma and Emergency Care Studies
- Infectious Aortic and Vascular Conditions
- Neuropeptides and Animal Physiology
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Barrier Structure and Function Studies
- Neonatal Respiratory Health Research
- Vascular Malformations Diagnosis and Treatment
Nanjing Medical University
2019-2025
Nanjing Brain Hospital
2025
Nanjing Chest Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Tongji Hospital
2007-2024
Huazhong University of Science and Technology
2009-2024
Guangzhou University of Chinese Medicine
2024
Lanzhou University Second Hospital
2019-2024
Lanzhou University
2019-2024
305 Hospital of People Liberation Army
2024
Background and Purpose— Symptomatic intracranial hemorrhage (SICH) pose a major safety concern for endovascular treatment of acute ischemic stroke. This study aimed to evaluate the risk related factors SICH after in real-world practice. Methods— Patients with stroke treated stent-like retrievers recanalizing blocked artery anterior circulation were enrolled from 21 centers China. Intracranial was classified as symptomatic asymptomatic ones according Heidelberg Bleeding Classification....
Abstract We propose a novel approach for predicting stress severity by measuring sleep phasic heart rate variability (HRV) using smart device. This device can potentially be applied self‐screening in large populations. Using Holter electrocardiogram (ECG) and Huawei device, we conducted 24‐h dual recordings of 159 medical workers working regular shifts. Based on photoplethysmography (PPG) accelerometer signals acquired the sorted episodes cyclic alternating pattern (CAP; unstable sleep),...
<b><i>Backgrounds and Purpose:</i></b> This study was aimed at investigating the outcomes predictors for poor functional outcome after endovascular treatment (EVT) in a large, mostly Asian population. <b><i>Methods:</i></b> Between January 2014 June 2016, acute stroke patients with anterior circulation occlusion EVT were retrospectively enrolled from 21 centers China. The main modified Rankin Scale (0-2 as independence, 3-6 poor) 90 days,...
Stroke remains the leading cause of death and disability worldwide.This fact highlights need to search for potential drug targets that can reduce stroke-related brain damage.We showed recently a glycogen synthase kinase-3β (GSK-3β) inhibitor attenuates tissue plasminogen activator-induced hemorrhagic transformation after permanent focal cerebral ischemia.Here, we examined whether GSK-3β inhibition mitigates early ischemia-reperfusion stroke injury investigated its mechanism action.We used...
Non-small cell lung cancer (NSCLC) predominantly affects older adults; these patients have significant comorbidities, making them unsuitable for chemotherapy. This study aimed to evaluate the efficacy and safety of immune checkpoint inhibitor (ICI) along with anlotinib combination therapy as a first-line treatment in NSCLC programmed death ligand-1(PD-L1) expression＜50%. We conducted retrospective observational including 73 advanced treated at Nanjing Brain Hospital. All were aged 75 years...
There has been increasing interest in the use of anticonvulsant agents treatment alcoholism. Anticonvulsant have mostly evaluated as an alternative to benzodiazepines alcohol withdrawal. Among advantages using this capacity is their purported lack interaction with (i.e., interactions that could increase psychomotor deficits, cognitive impairment, and intoxication). This particularly important withdrawal relapse prevention outpatients. Unfortunately, these untoward clinical between...
Subarachnoid hemorrhage (SAH) results in significant nerve dysfunction, such as hemiplegia, mood disorders, cognitive and memory impairment. Currently, no clear measures can reduce brain damage. The study of protection after SAH is great significance. We aim to evaluate the protective effects possible mechanism methazolamide C57BL/6J animal model vivo blood-induced primary cortical neuron (PCNs) cellular vitro. demonstrate that accelerates recovery neurological damage, effectively relieves...
This retrospective study aimed to investigate the predictive value of biomarkers for in-hospital mortality patients with Stanford type A acute aortic dissection (AAD).
Rationale: Prior approaches to measuring healthcare capacity strain have been constrained by using individual care units, limited metrics of strain, or general, rather than disease-specific, populations.Objectives: We sought develop a novel composite index and measure its association with intensive unit (ICU) admission decisions hospital outcomes.Methods: Using more 9.2 million acute encounters from 27 Kaiser Permanente Northern California Penn Medicine hospitals 2013 2018, we deployed...
Objective: The purpose of this study was to investigate whether routine blood tests on admission and clinical characteristics can predict prognosis in patients with traumatic brain injury (TBI) combined extracranial trauma. Methods: Clinical data 182 TBI trauma from April 2018 December 2019 were retrospectively collected analyzed. Based GOSE score one month after discharge, the divided into a favorable group (GOSE 1-4) unfavorable 5-8). Routine recorded. Results: Overall, there 48 (26.4%)...
Tissue plasminogen activator (tPA) is recommended by the FDA to dissolve intravascular clots after acute ischemic stroke (AIS). However, it may contribute hemorrhagic transformation (HT). The Wnt/β-catenin signaling pathway plays an important role in regulating blood-brain barrier (BBB) formation central nervous system. We explored whether glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (EX-4) reduces risk of HT rtPA treatment via using a rat transient middle cerebral artery...
Summary Aims Anxiety disorders are characterized by a deficient extinction of fear memory. Evidence is growing that leptin influences numerous neuronal functions. The aims this study were to investigate the effects and mechanism on extinction. Methods results Leptin (1 mg/kg, i.p) was applied evaluate anxiolytic effect in rat behavioral tests. Field potentials recording used changes synaptic transmission thalamic‐lateral amygadala ( LA ) pathway rat. We found produced strong under basal...
As negative regulators in Wnt signaling, Secreted Frizzled-Related Proteins (SFRPs) are downregulated a series of human cancers; and specifically, some matrix metalloproteinases (MMPs), including MMP-2, MMP-7, MMP-9 MT1-MMP, frequently overexpressed gastric cancer. The aim this study is to determine the expression status SFRP5 cancer explore correlation between both that these MMPs Expression SFRP5, MT1-MMP was determined by real-time PCR, RT-PCR or Western blotting. methylation detected...