A5100328040- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Amyotrophic Lateral Sclerosis Research
- Heart Rate Variability and Autonomic Control
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cell death mechanisms and regulation
- Neurogenetic and Muscular Disorders Research
- Autophagy in Disease and Therapy
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Obstructive Sleep Apnea Research
- Anesthesia and Neurotoxicity Research
- Genetic Neurodegenerative Diseases
- Esophageal Cancer Research and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Intracerebral and Subarachnoid Hemorrhage Research
Brigham and Women's Hospital
2013-2025
Harvard University
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Xinqiao Hospital
2025
Army Medical University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2018-2024
Chongqing Medical University
2018-2024
Shenzhen Children's Hospital
2023
Peking University
2022
The First Affiliated Hospital, Sun Yat-sen University
2022
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid cells from patients varying of COVID-19 and healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the severe COVID-9. Moderate cases presence highly clonally expanded CD8+ T cells. This atlas microenvironment suggests potential mechanisms underlying pathogenesis recovery...
Caspase-1 plays a key role in inflammatory pathways by processing pro-IL-1β into the active cytokine mature IL-1β. Given its sequence similarity with Caenorhabditis elegans cell death gene ced-3 ,it has long been speculated that caspase-1 may also play death. However, an unequivocal for questioned, and not definitively demonstrated. Furthermore, if does death, position apoptotic hierarchy clearly defined. Previous studies have shown knockout (KO) mice transgenic expressing dominant-negative...
Abstract The fact of melatonin as an important antioxidant in animals led plant researchers to speculate that also acts the similar manner plants. Although has significant effects on alleviating stress‐triggered reactive oxygen species ( ROS ), involvement direct oxidative stress and underlying physiological molecular mechanisms remain unclear In this study, we found exogenous significantly alleviated hydrogen peroxide (H 2 O )‐modulated growth, cell damage, accumulation Bermuda grass....
Release of mitochondrial cytochrome c resulting in downstream activation cell death pathways has been suggested to play a role neurologic diseases featuring death. However, the specific biologic importance release not demonstrated Huntington's disease (HD). To evaluate release, we screened drug library identify new inhibitors from mitochondria. Drugs effective at level purified mitochondria were evaluated cellular model HD. As proof principle, one was chosen for depth evaluation vitro and...
Abstract The function of melatonin as a protective agent against newborn hypoxic‐ischemic (H‐I) brain injury is not yet well studied, and the mechanisms by which causes neuroprotection in neurological diseases are still evolving. This study was designed to investigate whether expression MT 1 receptors reduced H‐I action alterations receptors. We demonstrated that there significant reduction ischemic mouse pups vivo following offers through upregulation role further supported observation...
Hypertension is a common outcome associated with obstructive sleep apnea (OSA), prevalent yet poorly treated cardiovascular disease. Recent studies showed oxytocin (OXT), released from hypothalamic paraventricular nucleus (PVN) neurons, activates cardiac vagal neurons in the dorsal motor of vagus (DMNX) and may blunt responses to stress. This study tests whether release OXT PVN fibers DMNX diminished chronic intermittent hypoxia-hypercapnia (CIH/H) exposure, an animal model OSA, activation...
MicroRNAs (miRNAs) are suspected to be a contributing factor in amyotrophic lateral sclerosis (ALS). Here, we assess the altered expression of miRNAs and effects miR-124 astrocytic differentiation neural stem cells ALS transgenic mice. Differentially expressed miRNA-positive (including miR-124, miR-181a, miR-22, miR-26b, miR-34a, miR-146a, miR-219, miR-21, miR-200a, miR-320) were detected by situ hybridization qRT-PCR spinal cord brainstem. Our results demonstrated that was down-regulated In...
Abstract Amyotrophic lateral sclerosis ( ALS ) is a neurodegenerative disease characterized by progressive motor neuron loss. Evidence suggests that mitochondrial dysfunction, apoptosis, oxidative stress, inflammation, glutamate excitotoxicity, and proteasomal dysfunction are all responsible for pathogenesis. N‐acetyl‐tryptophan has been identified as an inhibitor of cytochrome c release therefore potential neuroprotective agent. By quantifying cell death, we demonstrate N‐acetyl‐ l...
Purpose: We constructed a prediction model to predict 2-year locoregional recurrence based on the clinical features and radiomic extracted from machine learning method using computed tomography (CT) before definite chemoradiotherapy (dCRT) in locally advanced esophageal cancer. Patients methods: A total of 264 patients (156 Beijing, 87 Tianjin, 21 Jiangsu) were included this study. All those cancer received radiotherapy randomly divided into five subgroups with similar number training groups...
Abstract This study was to characterize the neuroprotective effects of nortriptyline, a tricyclic antidepressant, in mouse models chronic neurodegeneration [amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD)]. Nortriptyline originally selected from library screening 1040 FDA‐approved drugs by using isolated mitochondria. It emerged as strong inhibitor mitochondrial permeability transition (mPT). Our results showed that nortriptyline significantly delayed onset extended...
Objective: To investigate the effect of HSV-1 infection via TLR3 on transcriptional activity NF-kappaB and expression cytokines TNF-alpha IL-6 in astrocytes.Methods: HSV-1-infected primary astrocytes were cultured until third passage mRNA protein levels TLR3, NF-kappaB, TNF-alpha, assessed by immunofluorescence, RT-PCR, Western blot. The effects inhibitor pyrrolidine dithiocarbamate (PDTC) TLR3-neutralizing antibody investigated.Results: Uninfected expressed at levels. After with HSV-1,...
Subarachnoid hemorrhage (SAH) results in significant nerve dysfunction, such as hemiplegia, mood disorders, cognitive and memory impairment. Currently, no clear measures can reduce brain damage. The study of protection after SAH is great significance. We aim to evaluate the protective effects possible mechanism methazolamide C57BL/6J animal model vivo blood-induced primary cortical neuron (PCNs) cellular vitro. demonstrate that accelerates recovery neurological damage, effectively relieves...
The inflammatory receptor Toll-like receptors (TLRs) activation could induce endothelial responses, which plays an important role in the development of many diseases including atherosclerosis. We already found that TLR2 Peptidoglycan (PGN) stimulation increase intercellular adhesion molecule-1 (ICAM-1) expression HCAECs. Since anti-inflammatory cytokine interleukin (IL)-37 exhibits intra- and extracellular properties for suppressing innate inflammation, we want to investigate whether IL-37...