A5076439829- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Nanoplatforms for cancer theranostics
- Supercapacitor Materials and Fabrication
- Vascular Malformations Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Brain Metastases and Treatment
- Luminescence Properties of Advanced Materials
- RNA modifications and cancer
- Neurofibromatosis and Schwannoma Cases
- Guidance and Control Systems
- Cancer, Hypoxia, and Metabolism
- Parasites and Host Interactions
- Cancer Mechanisms and Therapy
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Ferroptosis and cancer prognosis
- Cerebrospinal fluid and hydrocephalus
- Computational Fluid Dynamics and Aerodynamics
- Circular RNAs in diseases
- RNA Research and Splicing
- Bone Tissue Engineering Materials
Jilin University
2016-2025
First Hospital of Jilin University
2016-2025
Qilu Hospital of Shandong University
2025
Beijing University of Chinese Medicine
2018-2024
First Bethune Hospital of Jilin University
2011-2024
Shenzhen Pingle Orthopedic Hospital
2024
Sun Yat-sen University
2022-2024
Children's Hospital of Fudan University
2023-2024
Nanjing Normal University
2022-2023
Zhongshan Ophthalmic Center, Sun Yat-sen University
2023
The trivalent lanthanides have been broadly utilized as emitting centers in persistent luminescence (PersL) materials due to their wide spectral range, which thus attract considerable attention over decades. However, the origin of lanthanides' PersL is still an open question, hindering development excellent phosphors and broad applications. Here, 12 kinds with exception La3+, Lu3+, Pm3+ reported, a mechanism bandgap hosts proposed. According mechanism, excitons transfer recombination energy...
The prognosis of leptomeningeal metastasis (LM) from solid tumors is extremely poor, especially for patients with adverse prognostic factors. In this phase II clinical trial, we evaluated the efficacy and safety intrathecal chemotherapy (IC) combined concomitant involved‐field radiotherapy (IF‐RT) treating LM Fifty‐nine various were enrolled between May 2010 December 2014. Concurrent therapy consisted IC (methotrexate 12.5–15 mg dexamethasone 5 mg, weekly) IF‐RT (whole brain and/or spinal...
The occurrence of remote epidural hematoma as a postoperative complication after intracranial tumor resection is rare. This study reviewed experiences treating these hematomas and speculated on the causes this disease. treatment experience 14 such cases. patients included 10 males 4 females, with an age range 19 to 65 years old. Six cases tumors occurred in sellar region, two lateral ventricle, one case fourth cerebellar hemisphere, four other sites. Among them, five were complicated...
// Zhiyun Yu 1 , Gang Zhao Guifang Xie 2 Liyan 3 Yong Chen Hongquan Zhonghua Zhang Cai Li 4 Yunqian Department of Neurosurgery, First Hospital Jilin University, Changchun, China Obstetrics and Gynecology, Clinical Laboratory, Second Experimental Pharmacology Toxicology, School Pharmacy, Correspondence to: Li, e-mail: 664857729@qq.com Keywords: AMPK, AKT-mTOR, glioma stem cell, metformin, temozolomide Received: May 20, 2015 Accepted: September 14, Published: 26, ABSTRACT Glioblastoma (GBM) is...
Nonalcoholic fatty liver disease (NAFLD) has become one of the most prominent causes chronic diseases and malignancies. However, few therapy been approved. Radix Bupleuri (RB) is frequently used herbal medicine for treatment diseases. In current study, we aim to systemically evaluate therapeutic effects saikosaponin A (SSa) D (SSd), major bioactive monomers in RB, against NAFLD investigate underlying mechanisms. Our results demonstrated that both SSa SSd improved diet-induced NAFLD....
Glioblastoma (GBM) is a highly infiltrative brain tumor. The treatment of GBM challenging due to the existence blood barrier, its invasive nature, and heterogeneity. Given limitations conventional therapies, this Perspective explores development trajectory implantable devices, highlighting advantages current models. With progression in research, these devices certainly hold promising potential for therapy.
// Guangtong Zhou 1 , Xinrui Liu Yunqian Li Songbai Xu Chengyuan Ma Xinmin Wu Ye Cheng Zhiyun Yu Gang Zhao Yong Chen Department of Neurosurgery, First Hospital Jilin University, Changchun, China Correspondence to: Chen, e-mail: cy_9201982@aliyun.com Zhao, zhao_gangjlu@aliyun.com Keywords: telomere, G-quadruplex, telomerase, DNA damage, T-loop Received: August 19, 2015     Accepted: January 29, 2016     Published: February 18, 2016 ABSTRACT Interference...
Gliomas are the most common type of all central nervous system tumors. Almost patients diagnosed with these tumors have a poor prognostic outcome. We aimed to identify novel glioma prognosis-associated candidate genes.We applied WebArrayDB software span platform integrate and analyze microarray datasets. focused on subset significantly up-regulated genes, minichromosome maintenance (MCM) family. used frozen samples predict relationship between expression MCMs outcome by qPCR western blot.We...
Background Dyslipidemia and lipotoxicity-induced insulin resistance, inflammation oxidative stress are the key pathogeneses of renal damage in type 2 diabetes. Increasing evidence shows that whole-body low dose radiation (LDR) plays a critical role attenuating stress. Objective The aims present study were to investigate whether LDR can prevent diabetes-induced underlying mechanisms. Methods Mice fed with high-fat diet (HFD, 40% calories from fat) for 12 weeks induce obesity followed by...
Glioblastoma (GBM) is the most common and malignant intracranial tumor in adults. Despite continuous improvements diagnosis therapeutic method, prognosis still far away from expectations. The invasive phenotype of GBM main reason for poor prognosis. Epithelial-mesenchymal transition (EMT) recognized as a participator this phenotype. Resveratrol, natural plant-derived compound, reported to be able regulate EMT. In present study, we used TGF-β1 induce EMT aimed evaluate effect resveratrol on...
AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I II clinical trials for treatment of several cancers. However, mechanisms by which targets kills glioma cells tissues remain unclear. Here we report that induces cell apoptosis cycle arrest, inhibits viability up-regulation p53 down-regulation Bcl-2 Akt1 in human cells. NCL was overexpressed both nucleus cytoplasm U87, U251 SHG44 compared normal astrocytes (NHA). bound inhibited proliferation but not...
Aging slows down the mechanisms behind skeletal muscle weakening and mobility. Increases in inflammation brought on by aging may contribute to some characteristics of sarcopenia. As a result population worldwide, sarcopenia, an age‐related disease, has become huge burden both individuals society as whole. The study morbidity mechanism available sarcopenia treatments received more attention. inflammatory response be one most important methods pathophysiology aged, according background study....
Abstract Background SIRPB1 expression is upregulated in various tumor types, including gliomas, and known to contribute progression; nevertheless, its function the immune milieu of gliomas still mainly unknown. Methods This study, we analyzed 1152 normal samples from GTEx database 670 glioma TCGA investigate relationship between clinicopathological features. Moreover, gene knockout THP-1 cell lines were constructed using CRISPR/Cas9 induced into a co-culture macrophages cells vitro learn...
A novel "dissolution-capture" method for the fabrication of nitrogen-doped hollow mesoporous spherical carbon capsules (N-HMSCCs) with high capability supercapacitor is developed. The process performed by depositing silica on surface polyacrylonitrile nanospheres, followed a dissolution-capture occurring in core and shell. dissolved dimethylformamide treatment to form cavity. Then, captured into mesochannel silica. After carbonization etching silica, N-HMSCCs uniform mesopore size are...
Glioblastoma is the most common and aggressive brain tumor in adults. The introduction of temozolomide (TMZ) has advanced chemotherapy for malignant gliomas, but it not curative. difficulties treating glioblastoma may be as a result presence glioma stem cells (GSCs), which are source relapse chemoresistance. Another reason that endogenous Akt kinase activity activated response to clinically relevant concentrations TMZ. activation correlated with increased tumorigenicity, invasiveness...