A5114949349- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- COVID-19 Clinical Research Studies
- Bone and Joint Diseases
- Bone fractures and treatments
- Long-Term Effects of COVID-19
- Infection Control and Ventilation
- Reconstructive Surgery and Microvascular Techniques
- Hip disorders and treatments
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Meningioma and schwannoma management
- Peroxisome Proliferator-Activated Receptors
- COVID-19 epidemiological studies
- Orthopedic Infections and Treatments
- Hip and Femur Fractures
- Sarcoma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Rheumatoid Arthritis Research and Therapies
- Protein Degradation and Inhibitors
- Vascular Procedures and Complications
Guangzhou Medical University
2023-2025
Huizhou University
2023-2025
Shandong First Medical University
2014-2024
Wuhan University
2010-2024
Xi’an Children’s Hospital
2024
Zhongnan Hospital of Wuhan University
2010-2024
Shenzhen University
2022-2024
Weifang Medical University
2024
Shanghai Maritime University
2024
Third Affiliated Hospital of Guangzhou Medical University
2023
In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named "2019 novel coronavirus (2019-nCoV)" by the World Health Organization (WHO) on 12 January 2020. For it is never been experienced respiratory disease before with infection ability widely quickly, attracted world's attention but without treatment control manual. request from frontline clinicians public health professionals of 2019-nCoV infected management, an evidence-based guideline urgently...
ObjectivesPrevious studies on the pneumonia outbreak caused by 2019 novel coronavirus disease (COVID-19) were based information from general population. However, limited data was available for severe acute respiratory syndrome 2 (SARS-CoV-2) reactivation. This study aimed to evaluate clinical characteristics of SARS-CoV-2 reactivation.MethodsClinical records, laboratory results, and chest CT scans retrospectively reviewed 55 patients with laboratory-confirmed COVID-19 (i.e., throat swab...
The prognosis of leptomeningeal metastasis (LM) from solid tumors is extremely poor, especially for patients with adverse prognostic factors. In this phase II clinical trial, we evaluated the efficacy and safety intrathecal chemotherapy (IC) combined concomitant involved‐field radiotherapy (IF‐RT) treating LM Fifty‐nine various were enrolled between May 2010 December 2014. Concurrent therapy consisted IC (methotrexate 12.5–15 mg dexamethasone 5 mg, weekly) IF‐RT (whole brain and/or spinal...
Abstract Importance A large number of healthcare workers (HCWs) were infected by SARS-CoV-2 during the ongoing outbreak COVID-19 in Wuhan, China. Hospitals are significant epicenters for human-to-human transmission HCWs, patients, and visitors. No data has been reported on details hospital environmental contamination status epicenter Wuhan. Objective To investigate extent to which contaminates settings, including identify function zones with highest levels most contaminated objects, personal...
In this study, we examined the characteristics and aimed to increase knowledge of clinical features leptomeningeal metastasis (LM). The data, including initial diagnosis treatment primary tumor, manifestations, neuroimaging findings, cerebrospinal fluid (CSF) examination, were analyzed. For patients with adenocarcinoma/breast cancer, incidence cranial lesions nerve paralysis was obviously higher than small cell lung cancer. Whereas, involvement intravertebral canal lower that Patients cancer...
Abstract Background The imbalance of osteogenic/adipogenic differentiation bone marrow mesenchymal stem cells (BMSCs) is closely related to steroid-induced avascular necrosis the femoral head (SANFH). We aimed investigate epigenetic mechanism intramedullary fat accumulation and continuous osteonecrosis after glucocorticoid (GC) withdrawal in SANFH. Methods An SANFH model was established SD rats, which received an intermittent high GC dose for first 4 weeks followed by additional without GC....
ABSTRACT Metastasis remains a leading cause of cancer‐related deaths, defined by complex, multi‐step process in which tumor cells spread and form secondary growths distant tissues. Despite substantial progress understanding metastasis, the molecular mechanisms driving this development effective therapies remain incompletely understood. Elucidating pathways governing metastasis is essential for discovery innovative therapeutic targets. The rapid advancements sequencing technologies expansion...
This study examined the hospital-wide effect of a mandatory 8-hour preceptor workshop on preceptors and orientees.A mixed-methods approach (QUAN + qual) with quasi-experimental design was used to test nurse preceptors' self-reported confidence comfort (pre- postworkshop) in five specific roles addition frequency coaching critical thinking providing formal feedback. Additionally, survey items compared cross-sectional cohorts orientees pre- postworkshop. Orientee retention rates were for 1...
A phase I/II study of intrathecal pemetrexed (IP) combined with involved-field radiotherapy (IFRT) was performed to determine feasibility, safety, and antitumor activity for leptomeningeal metastases (LM) from solid tumors.Participants first received induction IP administration, followed by concomitant within 3 days. The regimen consisted (pemetrexed 10 mg, dexamethasone 5 once per week, 4 times in weeks) IFRT (40 Gy 20 fractions). Six participants were recruited assess feasibility I, then...
Abstract 2019-nCoV had caused pneumonia outbreak in Wuhan. Existing evidence have confirmed the human-to-human transmission of 2019-nCoV. We retrospectively collected infection data from 2 January to 22 at six departments Zhongnan Hospital Wuhan University. In our study, we found N95 respirators, disinfection and hand washing can help reduce risk medical staffs. Our results call for re-emphasizing strict occupational protection code battling this novel contagious disease. The was higher open...
Increasing evidence indicates the important roles of M(3) muscarinic acetylcholine receptors (M(3) mAChR) in regulation and maintenance cardiac function heart disease. In present study, we investigated whether mAChR mediates cardioprotection against ischaemia-induced arrhythmias mechanisms involved. Myocardial ischaemia was established Wistar rats by occlusion left anterior descending coronary artery. Rats were treated with choline chloride (an agonist; 10 mg/kg, i.v.) min before occlusion....
Surgical resection serves an important role in the multidisciplinary treatment of cerebral metastases (CMs). Conventional white-light, microsurgical, and circumferential stripping CMs is standard neurosurgical procedure, but associated with a high recurrence rate. Based on this outcome, there urgent need for new surgical strategy, such as fluorescence-guided resection, CMs, order to achieve total removal.A retrospective study was carried out 38 patients clinically pathologically diagnosed...
We aimed to investigate clinical symptoms and epidemiologic features of emergency surgery patients infected with the 2019 novel coronavirus disease (COVID-19). More than 5 million people worldwide have been diagnosed COVID-19 since December time this publication. Thousands operations carried out 2019. To date, however, no literature has focused on pneumonia.We conducted a retrospective cohort study 164 or without pneumonia in Zhongnan Hospital Wuhan University Wuhan, China, from January 1,...
Abstract Background To the best of our knowledge, muscle soreness is a common manifestation for coronavirus disease-19 (COVID-19) patients, but mechanism severe acute respiratory syndrome 2 (SARS-CoV-2) injury to skeletal remains unclear, there has been no publication focused on involvement in COVID-19 patients. Case presentation We present case two Chinese men with COVID-19, whose symptoms were fatigue and soreness. They went through different treatments, patient 1, 81-year-old, eventually...
Bioinspired strontium magnesium phosphate cements for bone tissue engineering were prepared using a new, facile, environmentally friendly and high yielding (98.5%) precursor method. The bioinspired SMPCs have uniform particle distributions, excellent mechanical strengths biocompatibilities. in vitro responses of marrow stromal cells to the SMPCs, including viability, osteogenic differentiation alkaline phosphatase activity, evaluated. results show that SMPC containing 0.5 mol (referred as...
Abstract In this study, we investigated the clinical outcome of treatment displaced femoral neck fractures with vascularized great trochanter periosteal flap transposition in children. There were 23 children fractures. Using Delbet classification, there 2 type I (transepiphyseal), 12 II (transcervical), and 9 III (cervicotrochanteric). All treatments carried out transposition, fixed by Kirschner needle or hollow screws. Both methods achieved healing patients followed from months to 5 years,...
The object of this study was to compare the outcomes vacuum assisted closure (VAC) therapy and conventional wound care with dressing change for treatment complex wounds in patients replantation amputated upper lower extremities. Data 43 extremities from May 2004 December 2011 were reviewed. There 18 replantation, which treated by 26 25 VAC therapy. evaluated survival rate replanted extremities, growth granulation tissue, interval between secondary procedure eventual coverage methods....
The aim of the present study was to investigate association between glucocorticoid receptors and steroid‑induced avascular necrosis femoral head (SANFH). Healthy New Zealand rabbits were randomly divided into 3 groups (n=16/group); normal (no treatment), control (horse serum injections) treatment methylprednisolone groups. Methylprednisolone horse injections used establish a SANFH model in rabbits; magnetic resonance imaging (MRI) histopathological analysis evaluate rabbit model. Total...
Background: Leptomeningeal metastasis (LM) has frequently been observed in patients with lung adenocarcinoma. So far, its diagnosis and disease course monitoring are still extremely difficult. Moreover, there is no effective treatment regimen for LM due to a lack knowledge on the molecular mechanism of LM. This study aimed identify LM-related cerebrospinal fluid (CSF) miRNAs, which have potential value diagnosing exploring mechanism. Methods: CSF miRNAs were screened verified by microarray...