A5101479571- Reconstructive Surgery and Microvascular Techniques
- Bone fractures and treatments
- Surgical site infection prevention
- Wound Healing and Treatments
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- COVID-19 and healthcare impacts
- Nerve injury and regeneration
- Cancer, Hypoxia, and Metabolism
- Hip and Femur Fractures
- RNA Research and Splicing
- Photoacoustic and Ultrasonic Imaging
- Trauma and Emergency Care Studies
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- Sarcoma Diagnosis and Treatment
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Hip disorders and treatments
- Bone Tissue Engineering Materials
- Healthcare Systems and Public Health
- Optical Imaging and Spectroscopy Techniques
- Peripheral Nerve Disorders
- Protease and Inhibitor Mechanisms
Wuhan University
2014-2025
Zhongnan Hospital of Wuhan University
2014-2025
Southern Medical University
2020
Nanfang Hospital
2020
Compared with imaging in the visible (400–650 nm) and near‐infrared window I (NIR‐I, 650–900 regions, II (NIR‐II, 1000–1700 is a highly promising vivo modality improved resolution deeper tissue penetration. Here, small molecule NIR‐II dye,5,5′‐(1H,5H‐benzo[1,2‐c:4,5‐c′] bis[1,2,5]thiadiazole)‐4,8‐diyl)bis( N , ‐bis(4‐(3‐((tert‐butyldimethylsilyl)oxy)propyl)phenyl) thiophen‐2‐amine), successfully encapsulated into phospholipid vesicles to prepare probe CQS1000. The novel studied for...
Recently, various second near-infrared window (NIR-II, 1000-1700 nm) fluorophores have been synthesized for in vivo imaging with nonradiation, high resolution, and low autofluorescence. However, most of the NIR-II fluorophores, especially inorganic nanoprobes, are mainly retained reticuloendothelial system (RES) such as liver spleen, leading to long-term safety concerns. Herein, a type lanthanide-based excretable nanoparticle, RENPs@Lips, which can be quickly cleared out body after...
Abstract The dysfunction of the circulatory system leads to various pathological processes with high morbidity. Recently, fluorescence imaging in near‐infrared II (NIR‐II) window (1000–1700 nm) has attracted immense attention many biological processes. rapid metabolism and low toxicity some NIR‐II organic small molecules indicate their feasibility for use visualizing system. However, most reported presently encounter such dilemmas as complicated synthetic procedures quantum yields (QY). To...
Abstract A critical challenge of existing cancer vaccines is to orchestrate the demands antigen‐enriched furnishment and optimal antigen‐presentation functionality within antigen‐presenting cells (APCs). Here, a complementary immunotherapeutic strategy developed using dendritic cell (DC)‐tumor hybrid cell‐derived chimeric exosomes loaded with stimulator interferon genes (STING) agonists (DT‐Exo‐STING) for maximized tumor‐specific T‐cell immunity. These carriers are furnished broad‐spectrum...
Negative pressure wound therapy (NPWT) has been observed to accelerate the healing process in humans through promoting angiogenesis. However, potential biological effect and relevant molecular mechanisms, including microvessel destabilization, regression endothelial cell proliferation early stage (1-3 days), neovascular stabilization maturation later (7-15 have yet be fully elucidated. The current study aimed research of NPWT on angiogenesis vessel maturation, investigate association between...
Diabetes mellitus is a metabolic disorder that increases fracture risk and interferes with bone formation impairs healing. Genomic studies on diabetes healing are lacking. We used weighted co-expression network analysis (WGCNA) method to identify susceptibility modules hub genes associated T2DM First, we downloaded the GSE95849, GSE93213, GSE93215, GSE142786 data from Gene Expression Omnibus (GEO) website, analyzed differential expression constructed WGCNA network. Second, screened out 30...
Vacuum‐assisted closure (VAC) device is widely used to treat infected wounds in clinical work. Although the effect of VAC with different negative pressure values well established, whether pressures could result varying modulation wound relative cytokines was not clear. We hypothesise that instead highest value suitable for one which most effective on regulating cytokines. Infected created pigs' back were investigate effects devices. Wounds treated or moist gauze, set as control. The foam,...
Abstract Systematic administration of antibiotics to treat infections often leads the rapid evolution and spread multidrug‐resistant bacteria. Here, an in situ‐formed biotherapeutic gel that controls bacterial accelerates wound healing is reported. This constructed by incorporating stable microbial communities (kombucha) capable producing antimicrobial substances organic acids into thermosensitive Pluronic F127 (polyethylene‐polypropylene glycol) solutions. Furthermore, it found...
Severe traumatic wounds are challenging to manage during surgery. The introduction of vacuum-assisted closure (VAC) is a breakthrough in wound management. aim the present study was investigate effect VAC on cytokines management severe following initial debridement. and conventional care (CWC) were independently applied pigs. expression levels intercellular adhesion molecule-1 (ICAM-1), migration inhibitory factor (MIF), vascular endothelial growth (VEGF), basic fibroblast factor, collagen I...
Poor viability of engrafted bone marrow mesenchymal stem cells (BMSCs) often hinders their application for wound healing, and the strategy how to take full advantage angiogenic capacity within wounds still remains unclear. Negative pressure therapy (NPWT) has been demonstrated be effective enhancing especially promotion angiogenesis wounds. Here we utilized combinatory using transplantation BMSCs NPWT investigate whether this could accelerate in In vitro, after 9-day culture, proliferation...
Vacuum-assisted closure (VAC) negative pressure wound therapy (NPWT) has been proven to be an effective therapeutic method for the treatment of recalcitrant wounds. However, its role in bone healing remains unclear. Here, we investigated effects NPWT on rat periosteum-derived mesenchymal stem cells (P-MSCs) proliferation and osteoblastic differentiation a 3D fibrin matrix. P-MSCs underwent primary culture three passages before being used construct cell clots. The clots were incubated with...
Since December 2019, many patients in Wuhan sustained pneumonia with unknown causes.[1,2] A part of severe developed acute respiratory distress syndrome or septic shock, and even death. On January 7, 2020, Chinese researchers have for the first time detected a new coronavirus. 20, National Health Commission issued Announcement No. 1 which included coronavirus as Class B infectious disease, conducted epidemic prevention control according to disease. This kind has been named disease 2019...
Neuroma formation after peripheral nerve transection often leads to severe neuropathic pain. Regenerative interface has been shown reduce painful neuroma in the clinic. However, no reports have investigated underlying mechanisms, and comparative animal studies on regenerative other means of prevention conducted date. In this study, we established a rat model left sciatic transfection, subsequently interfered with using or proximal stump implantation inside fully innervated muscle. Results...
Bioinspired strontium magnesium phosphate cements for bone tissue engineering were prepared using a new, facile, environmentally friendly and high yielding (98.5%) precursor method. The bioinspired SMPCs have uniform particle distributions, excellent mechanical strengths biocompatibilities. in vitro responses of marrow stromal cells to the SMPCs, including viability, osteogenic differentiation alkaline phosphatase activity, evaluated. results show that SMPC containing 0.5 mol (referred as...
Tumor recurrence and unfavorable bacterial biofilm formation on implants after bone tumor resection remain challenging in clinical settings. However, this dilemma also provides inspiration for the development of bioactive a new route management tumors through formation. Here, based characteristic that bacteria prefer to adhere implants, 3D-printing bioceramic scaffolds modified with probiotic biofilms are designed augment antitumor immunity. In comparison Akkermansia muciniphila,...
Abstract In this study, we investigated the clinical outcome of treatment displaced femoral neck fractures with vascularized great trochanter periosteal flap transposition in children. There were 23 children fractures. Using Delbet classification, there 2 type I (transepiphyseal), 12 II (transcervical), and 9 III (cervicotrochanteric). All treatments carried out transposition, fixed by Kirschner needle or hollow screws. Both methods achieved healing patients followed from months to 5 years,...
Aims and background Hypoxia is a fundamental microenvironmental component of osteosarcoma which induces activation the hypoxia-inducible factor-1 (HIF-1) pathway. Overexpression HIF-1α has been linked to tumor resistance radio- or chemotherapy. However, little known about effects inhibition on hypoxic radioresistance human cells. Here, we investigated cell survival radiosensitivity in MG-63 line. Methods was achieved by small interfering RNA (siRNA) targeting via chetomin. Inhibition HIF-1...
The object of this study was to compare the outcomes vacuum assisted closure (VAC) therapy and conventional wound care with dressing change for treatment complex wounds in patients replantation amputated upper lower extremities. Data 43 extremities from May 2004 December 2011 were reviewed. There 18 replantation, which treated by 26 25 VAC therapy. evaluated survival rate replanted extremities, growth granulation tissue, interval between secondary procedure eventual coverage methods....