A5073166534- Nanoplatforms for cancer theranostics
- Topic Modeling
- Complex Network Analysis Techniques
- Advanced Text Analysis Techniques
- Opinion Dynamics and Social Influence
- Luminescence and Fluorescent Materials
- Biomedical Text Mining and Ontologies
- Data Quality and Management
- Advanced Graph Neural Networks
- Recommender Systems and Techniques
- Sentiment Analysis and Opinion Mining
- Stock Market Forecasting Methods
- Photoacoustic and Ultrasonic Imaging
- Semantic Web and Ontologies
- Conferences and Exhibitions Management
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Digital Marketing and Social Media
- Forecasting Techniques and Applications
- Time Series Analysis and Forecasting
- Photodynamic Therapy Research Studies
- Natural Language Processing Techniques
- Misinformation and Its Impacts
- scientometrics and bibliometrics research
- Radiopharmaceutical Chemistry and Applications
First Affiliated Hospital of Zhengzhou University
2016-2025
Sun Yat-sen University
2018-2025
Zhongnan Hospital of Wuhan University
2019-2022
Wuhan University
2019-2022
Stanford University
2019-2021
Tsinghua University
2012-2016
Shanghai University of Finance and Economics
2010-2011
Indiana University
2010
Hunan Normal University
2009
Shanghai University
2009
As a newly noninvasive emerging modality, NIR-II fluorescence imaging (1000-1700 nm) has many advantages over conventional visible and NIR-I (700-900 nm). Unfortunately, only few fluorophores are suitable for bone imaging. Here, we report an fluorophore based on DSPE-mPEG encapsulated rare earth doped nanoparticles (RENPs@DSPE-mPEG), which shows inherent affinity to without linking any targeting ligands, thus, it provides alternative nonradiation strategy skeletal system mapping disease...
PubMed
Abstract Gene therapy holds great promise as a biomedicine for treating cancer, viral infection, and recessive gene disorders, while genetic detection has been used disease diagnosis prevention. The appropriate carrier is crucial to improve the delivery efficiency of nucleic acids. Although nonviral vectors have developed, their poor acid loading efficiency, off‐target toxicity, immunogenicity significantly hamper use. Metal‐organic frameworks (MOFs) attracted lot attention owing high...
Recently, various second near-infrared window (NIR-II, 1000-1700 nm) fluorophores have been synthesized for in vivo imaging with nonradiation, high resolution, and low autofluorescence. However, most of the NIR-II fluorophores, especially inorganic nanoprobes, are mainly retained reticuloendothelial system (RES) such as liver spleen, leading to long-term safety concerns. Herein, a type lanthanide-based excretable nanoparticle, RENPs@Lips, which can be quickly cleared out body after...
Abstract The dysfunction of the circulatory system leads to various pathological processes with high morbidity. Recently, fluorescence imaging in near‐infrared II (NIR‐II) window (1000–1700 nm) has attracted immense attention many biological processes. rapid metabolism and low toxicity some NIR‐II organic small molecules indicate their feasibility for use visualizing system. However, most reported presently encounter such dilemmas as complicated synthetic procedures quantum yields (QY). To...
To improve bone metastases treatment efficacy, current strategies are focused on the integration of chemotherapy with phototheranostic. However, success phototheranostic approaches is hampered by limited tissue penetration depth near-infrared-I (NIR-I) light (700-900 nm). In this study, a NIR-II (1000-1700 nm) excitation (BTZ/Fe2+ @BTF/ALD) presented for fluorescence imaging and photoacoustic imaging-guided photothermal therapy (PTT), chemotherapy, chemodynamic (CDT) breast cancer...
The overall survival rate of osteosarcoma (OS) patients has not been improved for 30 years, and the diagnosis treatment OS is still a critical issue. To improve prognosis, novel kinds theranostic modalities are required. Molecular optical imaging phototherapy, including photothermal therapy (PTT) photodynamic (PDT), promising strategies cancer theranostics that exhibit high sensitivity as well favorable therapeutic efficacy with minimal side effect. In this study, semiconducting polymer...
Bacterial infections pose a significant threat to global public health; therefore, the development of novel therapeutics is urgently needed. Herein, controllable antibacterial nanoplatform utilizing cyclodextrin metal-organic frameworks (CD-MOFs) as template synthesize ultrafine silver nanoparticles (Ag NPs) in their porous structure constructed. Subsequently, polydopamine (PDA) encapsulated on CD-MOFs' surface via dopamine polymerization enhance water stability and enable hyperthermia...
This work identifies changes in dominant topics library and information science (LIS) over time, by analyzing the 3,121 doctoral dissertations completed between 1930 2009 at North American Library Information Science programs. The authors utilize latent Dirichlet allocation (LDA) to identify diachronically representative of those topics. findings indicate that main LIS have changed substantially from initial period (1930–1969) present (2000–2009). However, some themes occurred multiple...
Abstract Multidrug resistance to clinical chemotherapeutic drugs severely limits antitumor efficacy and patient survival. The integration of chemotherapy with photothermal therapy (PTT) reactive nitrogen species has become a major strategy enhance cancer treatment efficacy. Herein, multifunctional peroxynitrite (ONOO − ) nanogenerator (PBT/NO/Pt) for NIR‐II fluorescence (NIR‐II FL)/NIR‐II photoacoustic PA) imaging‐guided chemo/NIR‐II PTT/ONOO combination is reported. multifunction developed...
Purpose: Session-based recommendation using graph neural networks (GNN) is a popular approach to model users? behaviors and attributes of items from the perspective user-item interaction sequence. However, current researches seldom incorporate unique delve into comprehensive analysis user behaviors. In addition, GNN faces three problems when encounting complex modeling scenarios: long-range dependencies, order information loss, data sparsity, which are essential long-tail items. Methods: We...
Abstract Implant‐associated infections (IAIs) are refractory to elimination, and the local immunosuppressive microenvironment (IME) exacerbates therapeutic difficulties, ultimately causing persistence relapse. Therefore, exploring immunostrengthening treatments holds great promise for reversing IME thoroughly eradicating chronic or repetitive infections. Bacterial outer membrane vesicles (OMVs) have emerged as potential immunostimulatory candidates; however, they lack active targeting...
Exploring community is fundamental for uncovering the connections between structure and function of complex networks practical applications in many disciplines such as biology sociology. In this paper, we propose a TTR-LDA-Community model which combines Latent Dirichlet Allocation (LDA) Girvan-Newman detection algorithm with an inference mechanism. The then applied to data from Delicious, popular social tagging system, over time period 2005-2008. Our results show that 1) users same tend be...
Scientific novelty drives the efforts to invent new vaccines and solutions during pandemic. First-time collaboration international are two pivotal channels expand teams' search activities for a broader scope of resources required address global challenge, which might facilitate generation novel ideas. Our analysis 98,981 coronavirus papers suggests that scientific measured by BioBERT model is pretrained on 29 million PubMed articles, first-time increased after outbreak COVID-19, witnessed...
Information from microblogs is gaining increasing attention researchers interested in analyzing fluctuations stock markets. Behavioral financial theory draws on social psychology to explain some of the irrational behaviors associated with decisions help fluctuations. In this study we argue that media users who demonstrate an interest finance can offer insights into ways which may affect a market. To test this, analyzed all data collected over 3‐month period 2011 Tencent Weibo (one largest...
Abstract Synergistic chemotherapy and photothermal therapy (PTT) have emerged as a promising anticancer paradigm to achieve expected therapeutic effects while mitigating side effects. However, the chemo/PTT combination suffers from limited penetration depth, thermoresistance performance of tumor cells, low drug bioavailability. Herein, multifunctional nanoparticles (BTP/DOX/2DG NPs) coloaded with near‐infrared region II (NIR‐II) light excitation donor–acceptor–donor (D–A–D) small molecules,...
Photothermal immunotherapy is regarded as the ideal cancer therapeutic modality to against malignant solid tumors; however, its benefits are often modest and require improvement. In this study, a thermoresponsive nanoparticle (BTN@LND) composed of photothermal agent (PTA) pyroptosis inducer (lonidamine) were developed enhance applications. Specifically, our "two-step" donor engineering strategy produced strong NIR-II-absorbing organic small-molecule PTA (BTN) that exhibited high NIR-II performance (ε
This paper proposes a Topic-Level Opinion Influence Model (TOIM) that simultaneously incorporates topic factor, user opinions and social influence in unified probabilistic model with two stages learning processes. In the first stage, factor are integrated to generate users' influential relationship based on different topics; second historical messages interaction records leveraged by TOIM construct their neighbors' opinion through statistical process, which can be further utilized predict...