A5100709276- Radiopharmaceutical Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Photoacoustic and Ultrasonic Imaging
- HER2/EGFR in Cancer Research
- Optical Imaging and Spectroscopy Techniques
- Biochemical and Structural Characterization
- Glycosylation and Glycoproteins Research
- bioluminescence and chemiluminescence research
- Click Chemistry and Applications
- Photodynamic Therapy Research Studies
- Chemical Synthesis and Analysis
- Advanced Biosensing Techniques and Applications
- Extracellular vesicles in disease
- Nanocluster Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Prostate Cancer Treatment and Research
- Protease and Inhibitor Mechanisms
- Advanced Nanomaterials in Catalysis
- Luminescence Properties of Advanced Materials
- Luminescence and Fluorescent Materials
Union Hospital
2024
Huazhong University of Science and Technology
2024
Heilongjiang University of Technology
2024
Northeastern University
2013-2023
Zhengzhou University of Science and Technology
2022
Universidad del Noreste
2018-2021
Nantong University
2015-2019
Taizhou People's Hospital
2019
Stanford University
2009-2018
Stanford Medicine
2010-2013
Background Optical imaging (OI) techniques such as bioluminescence and fluorescence have been widely used to track diseases in a non-invasive manner within living subjects. These generally require bioluminescent fluorescent probes. Here we demonstrate the feasibility of using radioactive probes for vivo molecular OI. Methodology/Principal Findings By taking advantages low energy window light (1.2–3.1 eV, 400–1000 nm) resulting from radiation, radionuclides that emit charged particles β+ β−...
Anisotropic colloidal hybrid nanoparticles exhibit superior optical and physical properties compared to their counterparts with regular architectures. We herein developed a controlled, stepwise strategy build novel, anisotropic, branched, gold nanoarchitectures (Au-tripods) predetermined composition morphology for bioimaging. The resultant Au-tripods size less than 20 nm showed great promise as contrast agents in vivo photoacoustic imaging (PAI). further identified two possible...
Amino-functionalized fluorescent carbon dots have been prepared by hydrothermal treatment of glucosamine with excess pyrophosphate. The produced showed stabilized green emission fluorescence at various excitation wavelengths and pH environments. Herein, we demonstrate the surface energy transfer between amino-functionalized negatively charged hyaluronate gold nanoparticles. Hyaluronidase can degrade break down nanoparticles to inhibit transfer. developed dot/gold nanoparticle system be...
Abstract Development of reporter genes for multimodality molecular imaging is highly important. In contrast to the conventional strategies which have focused on fusing several together serve as multimodal reporters, human tyrosinase (TYR) – key enzyme in melanin production was evaluated this study a stand-alone gene vitro and vivo photoacoustic (PAI), magnetic resonance (MRI) positron emission tomography (PET). Human breast cancer cells MCF-7 transfected with plasmid that encodes TYR (named...
Cerenkov luminescence imaging (CLI) is an emerging new molecular modality that relatively inexpensive, easy to use, and has high throughput. CLI can image clinically available PET SPECT probes using optical instrumentation. endoscopy (CLE) one of the most intriguing applications promise potential clinical translation. We developed a prototype customized fiberscopic system investigate in guiding minimally invasive surgical resection. <b>Methods:</b> All experiments were performed dark...
Abstract Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900 nm) as irradiation source. However, second (NIR-II; 1000–1700 especially NIR-IIa (1300–1400 is considered much more promising diagnosis superiority penetration depth maximum permissible exposure over NIR-I window. Hereby, we...
Endoscopy is a clinical gold standard to exam the interior of hollow organ or body cavity. For first time, this study presents design and construction fluorescent endoscopic system that harnesses power second near-infrared window II (NIR-II) fluorescence imaging. An NIR-II molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev-ICG) targets vascular endothelial growth factor (VEGF), successfully synthesized evaluated along with endoscopy imaging system. Simultaneous white-light...
Human copper transporter 1 (CTR1) is overexpressed in a variety of cancers. This study aimed to evaluate the use <sup>64</sup>CuCl<sub>2</sub> as theranostic agent for PET and radionuclide therapy malignant melanoma. <b>Methods:</b> CTR1 expression levels were detected by Western blot analysis group tumor cell lines. Two melanoma lines (B16F10 A375M) that highly expressed then selected uptake efflux <sup>64</sup>CuCl<sub>2</sub>. Mice bearing B16F10 or A375M tumors (<i>n</i> = 4 each group)...
Fibroblast activation protein-alpha (FAPα) is a cell surface glycoprotein which selectively expressed by tumor-associated fibroblasts in malignant tumors but rarely on normal tissues. FAPα has also been reported to promote tumor growth and invasion therefore of increasing interest as promising target for designing tumor-targeted drugs imaging agents. Although medicinal study inhibitors led the discovery many FAPα-targeting including drug candidate phase II clinical trial, development probes...
Cerenkov luminescence imaging (CLI) has emerged as a less expensive, easier-to-use, and higher-throughput alternative to other nuclear modalities such PET. It is expected that CLI will find many applications in biomedical research cancer detection, probe development, drug screening, therapy monitoring. In this study, we explored the possibility of using monitor efficacy by comparisons against To assess performance both monitoring, 2 murine tumor models (large cell lung line H460 prostate...
Near-infrared window IIb (NIR-IIb, 1500–1700 nm) fluorescence imaging demonstrates attractive properties including low scattering, absorption, and deep tissue penetration, photothermal therapy (PTT) is also a promising modality for cancer treatment. However, until now, there no report on theranostic systems based small organic molecules combining in the NIR-IIb PTT, highlighting challenge strong need development of such agents. Herein, we novel molecule dye IT-TQF with D–A–D structure, which...
Epidermal growth factor receptor (EGFR) has become an attractive target for cancer molecular imaging and therapy. Affibody proteins against EGFR have been reported, thus, we were interested in evaluating their potential positron emission tomography (PET) of positive cancer. An analogue (Ac-Cys-Z(EGFR:1907)) binding to was made through conventional solid phase peptide synthesis. The purified protein site-specifically coupled with the...
Radiolabeled bombesin (BBN) analogs that bind to the gastrin-releasing peptide receptor (GRPR) represent a topic of active investigation for development molecular probes PET or SPECT prostate cancer (PCa). RM1 and AMBA have been identified as 2 most promising BBN peptides GRPR-targeted imaging therapy. In this study, develop clinically translatable BBN-based probe, we synthesized evaluated <sup>18</sup>F-AlF- (aluminum-fluoride) <sup>64</sup>Cu-radiolabeled their potential application in...
Epidermal growth factor receptor (EGFR) is often overexpressed in a variety of human cancers, and its expression associated with poor prognosis for many cancer types. However, an accurate technique to noninvasively image EGFR vivo not available the clinical setting. In this research, Affibody analog, anti-EGFR Ac-Cys-Z<sub>EGFR:1907</sub>, was successfully site-specifically <sup>18</sup>F-labeled PET expression. <b>Methods:</b> The prosthetic group...
In microsurgery, it is always difficult to accurately identify the blood supply with ease, such as vascular anastomosis, digit replantation, skin avulsion reconstruction and flap transplantation. Near-infrared window I (NIR-I, 700-900 nm) imaging has many clinical applications, whereas near-infrared II (NIR-II, 1,000-1700 emerged a highly promising novel optical modality used in few fields recently, especially its penetration distance noninvasive characteristics coincide needs of...
Abstract Nanozymes with multienzyme‐mimicking activities have shown great potential in cancer therapy due to their ability modulate the complex tumor microenvironment (TME). Herein, a second near‐infrared (NIR‐II) photothermal‐nanocatalyst by decorating Bi 2 Te 3 nanosheets ultrasmall Au/Pd bimetallic nanoparticles (Bi ‐Au/Pd) reverse immunosuppressive TME is developed. The peroxidase (POD)‐like and catalase (CAT)‐like activities, glutathione (GSH) consumption capacity of modulates...
Dialkylamino-alkyl-benzamides possess an affinity for melanin, suggesting that labeling of such benzamides with <sup>18</sup>F could potentially produce melanin-targeted PET probes able to identify melanotic melanoma metastases in vivo high sensitivity and specificity. <b>Methods:</b> In this study, <i>N</i>-[2-(diethylamino)ethyl]-4-<sup>18</sup>F-fluorobenzamide (<sup>18</sup>F-FBZA) was synthesized via a 1-step conjugation reaction. The σ-receptor binding <sup>19</sup>F-FBZA determined...