A5062244244- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Laser-Plasma Interactions and Diagnostics
- Nanocluster Synthesis and Applications
- Mesoporous Materials and Catalysis
- Nuclear Physics and Applications
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Nuclear reactor physics and engineering
- Laser-Matter Interactions and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Crystallography and Radiation Phenomena
- Particle Accelerators and Free-Electron Lasers
- Mass Spectrometry Techniques and Applications
- Magnetic confinement fusion research
- Numerical methods in inverse problems
- Radiative Heat Transfer Studies
- Dendrimers and Hyperbranched Polymers
- Hydrogels: synthesis, properties, applications
- Advanced Polymer Synthesis and Characterization
- Laser-induced spectroscopy and plasma
- Photoacoustic and Ultrasonic Imaging
- Polymer Surface Interaction Studies
- Advanced Numerical Methods in Computational Mathematics
Wuhan University of Technology
2014-2025
Lawrence Livermore National Laboratory
1993-2024
Stanford University
2019-2023
Fudan University
2010-2018
General Atomics (United States)
2017
State Key Laboratory of Polymer Physics and Chemistry
2013
Space (Italy)
1985
HRL Laboratories (United States)
1977
We have measured the ion yields for helium ionized by 120 fs, 614 nm laser pulses intensities near ${10}^{16}$ W/${\mathrm{cm}}^{2}$. found that these ultrashort ${\mathrm{He}}^{+2}$ data exhibit a feature which saturates in parallel with ${\mathrm{He}}^{+}$ signal indicating ionization may proceed nonsequentially. propose new mechanism, can exist only tunneling regime, such nonsequential ionization.
Abstract Obtaining a burning plasma is critical step towards self-sustaining fusion energy 1 . A one in which the reactions themselves are primary source of heating plasma, necessary to sustain and propagate burn, enabling high gain. After decades research, here we achieve burning-plasma state laboratory. These experiments were conducted at US National Ignition Facility, laser facility delivering up 1.9 megajoules pulses with peak powers 500 terawatts. We use lasers generate X-rays radiation...
In this paper, a kind of core–shell composite microsphere was prepared based on poly(N-isopropylacrylamide-co-methacrylic acid) (P(NIPAM-co-MAA)) coated magnetic mesoporous silica nanoparticles (M-MSN) via precipitation polymerization. The presented thermo/pH-coupling sensitivity and the volume phase transition could be precisely regulated by molar ratio MAA to NIPAM or concentration NaCl. At physiological conditions (37 °C, 0.15 M NaCl), P(NIPAM-co-MAA) shell underwent distinct from swollen...
Abstract In a burning plasma state 1–7 , alpha particles from deuterium–tritium fusion reactions redeposit their energy and are the dominant source of heating. This has recently been achieved at US National Ignition Facility 8 using indirect-drive inertial-confinement fusion. Our experiments use laser-generated radiation-filled cavity (a hohlraum) to spherically implode capsules containing deuterium tritium fuel in central hot spot where occur. We have developed more efficient hohlraums...
The design of bioresponsive controlled drug delivery systems is a promising approach in cancer therapy, but it still major challenge capable optimum therapeutic efficacy, i.e. no premature leakage blood circulation while having rapid and complete release tumor tissues. In this work, kind PEGylated core/shell structured composite nanoparticle was developed via precipitation polymerization, where disulfide-cross-linked poly(N-vinylcaprolactam-co-methacrylic acid) (P(VCL-s-s-MAA)) polymer shell...
Poly(vinylcaprolactam) (PVCL)-based biodegradable microgels were prepared for the biomedical application as drug delivery system via precipitation polymerization, where N,N-bis(acryloyl) cystamine (BAC) served cross-linker, methacrylic acid (MAA) and polyethylene glycol (PEG) methyl ether methacrylate acted comonomers. The with excellent stability had distinct temperature sensitivity largely observed in case of PVCL-based particles their volume phase transition (VPTT) shifted to higher...
The modified sol–gel approach to the synthesis of well-structured magnetic mesoporous silica nanoparticles (M-MSNs) was described, which comprised resided within nanoparticles. A diversity surface modification subjected systematic investigation using organic silanes, eventually resulting in decoration with carboxyl (–COOH), methyl phosphonate (–PO3−), amino (–NH2) and phenyl (–Ph) groups on M-MSNs. careful characterizations demonstrated that M-MSNs displayed specifically charged surfaces...
Recently, various second near-infrared window (NIR-II, 1000-1700 nm) fluorophores have been synthesized for in vivo imaging with nonradiation, high resolution, and low autofluorescence. However, most of the NIR-II fluorophores, especially inorganic nanoprobes, are mainly retained reticuloendothelial system (RES) such as liver spleen, leading to long-term safety concerns. Herein, a type lanthanide-based excretable nanoparticle, RENPs@Lips, which can be quickly cleared out body after...
Abstract The dysfunction of the circulatory system leads to various pathological processes with high morbidity. Recently, fluorescence imaging in near‐infrared II (NIR‐II) window (1000–1700 nm) has attracted immense attention many biological processes. rapid metabolism and low toxicity some NIR‐II organic small molecules indicate their feasibility for use visualizing system. However, most reported presently encounter such dilemmas as complicated synthetic procedures quantum yields (QY). To...
Abstract Despite multifunctional theranostics hold vast potential in deep tissue bioimaging and tumor therapy, activatable nanomedicine with integration of precise diagnosis effective treatment is usually achieved at the cost complicated synthesis chemistries. Here, a facile way to design bioresponsive Ag 2 S‐Ag Janus probes coated by polyethylene glycol (PEG) (denoted as AAP) showed, active second near‐infrared window (NIR‐II, 1000–1700 nm). In microenvironment, part can yield hydroxyl...
Abstract Indirect Drive Inertial Confinement Fusion Experiments on the National Ignition Facility (NIF) have achieved a burning plasma state with neutron yields exceeding 170 kJ, roughly 3 times prior record and necessary stage for igniting plasmas. The results are despite multiple sources of degradations that lead to high variability in performance. Results shown here, first time, include an empirical correction factor mode-2 asymmetry regime addition previously determined corrections...
We report on the polarization dependence of ionization helium and neon by 120-fs pulses at 614 nm. For linearly polarized data for ${\mathrm{He}}^{2+}$ ${\mathrm{Ne}}^{2+}$ show enhancements over sequential tunneling. circularly no distinct enhancements. Dynamic resonances, which produce similar in multiphoton regime, do not explain tunneling regime. Two direct-ionization models are considered: a shake-off model, semiclassical model rescattering an electron ion core. The exhibited yield...
By employing poly (tert-butylacrylate) (PTBA) nanospheres as the dissolvable core templates, we develop a new method to synthesize hollow mesoporous silica nanoparticles (HMSN). Both PTBA and structure-directing surfactant, cetyltrimethylammonium bromide (CTAB), can be easily synchronously removed through solvent extraction in ethanol, which ensures complete structure ideal dispersibility of products compared with previous template synthesis that often needs calcination remove templates....
Novel composite nanoparticles based on poly(N-isopropylacrylamide-co-N-hydroxymethyl acrylamide) (P(NIPAM-co-NHMA)) layer coated gold nanorod@mesoporous silica (GNR@mSiO2) has been successfully synthesized by precipitation polymerization. The exhibited a thermo/near-infrared (NIR) light sensitivity. volume phase transition temperature (VPTT) could be precisely regulated the content of NHMA in monomers and an excellent photothermal conversion effect was expressed due to surface plasmon...
Abstract A controlled drug‐delivery system has been developed based on mesoporous silica nanoparticles that deliver anticancer drugs into cancer cells with minimized side effects. The copolymer of two oligo(ethylene glycol) macromonomers cross‐linked by the disulfide linker N , ′‐bis(acryloyl)cystamine is used to cap hollow (HMSNs) form a core/shell structure. HMSN core applied as drug storage unit for its high loading capability, whereas polymer shell employed switch owing redox/temperature...
Abstract Emerging stimuli‐responsive composite probes active in the second near‐infrared window (NIR‐II, 1000–1700 nm) hold vast potential for improving vivo imaging performance with minimized noise interference. The interactions among external irradiation, shell species, and emissive core are key factors design of smart structures. irradiation provides energy species to generate intense NIR‐II fluorescence signals, while transfer process hinders emission inner structure probes. However, if...
The thin membrane that holds the capsule in-place in hohlraum is recognized as one of most significant contributors to reduced performance indirect drive inertial confinement fusion (ICF) experiments on National Ignition Facility. This membrane, known “tent,” seeds a perturbation amplified by Rayleigh-Taylor and can rupture capsule. A less damaging support mechanism under development. Possible alternatives include micron-scale rods spanning width supporting either or stiffening fill-tube,...