A5101705828- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Photoacoustic and Ultrasonic Imaging
- Luminescence Properties of Advanced Materials
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Analytical Chemistry and Sensors
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Imaging and Spectroscopy Techniques
- Graphene research and applications
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Gas Sensing Nanomaterials and Sensors
- Quantum Dots Synthesis And Properties
- Carbon and Quantum Dots Applications
- Advanced biosensing and bioanalysis techniques
- Carbon Nanotubes in Composites
- Fiber-reinforced polymer composites
- Radio Wave Propagation Studies
- Extracellular vesicles in disease
- Corneal Surgery and Treatments
- Photoreceptor and optogenetics research
- Polydiacetylene-based materials and applications
Stanford University
2018-2025
Shenzhen Technology University
2021-2025
Shenzhen Bay Laboratory
2022-2025
Singapore University of Technology and Design
2016-2024
Southern University of Science and Technology
2019-2020
Shenzhen University
2018-2019
Institute of Coal Chemistry
2011-2016
Max Planck Institute for Polymer Research
2014-2015
Max Planck Society
2015
University of Applied Sciences Mainz
2014
Fluorescence probes in the NIR-IIa region show drastically improved imaging owing to reduced photon scattering and autofluorescence biological tissues. Now, polymer dots (Pdots) are developed with a dual fluorescence enhancement mechanism. First, aggregation induced emission of phenothiazine was used reduce nonradiative decay pathways polymers condensed states. Second, quenching minimized by different levels steric hindrance further boost fluorescence. The resulting Pdots displayed QY ca....
As a newly noninvasive emerging modality, NIR-II fluorescence imaging (1000-1700 nm) has many advantages over conventional visible and NIR-I (700-900 nm). Unfortunately, only few fluorophores are suitable for bone imaging. Here, we report an fluorophore based on DSPE-mPEG encapsulated rare earth doped nanoparticles (RENPs@DSPE-mPEG), which shows inherent affinity to without linking any targeting ligands, thus, it provides alternative nonradiation strategy skeletal system mapping disease...
Here, we describe a fluorination strategy for semiconducting polymers the development of highly bright second near-infrared region (NIR-II) probes. Tetrafluorination yielded fluorescence QY 3.2 % polymer dots (Pdots), over 3-fold enhancement compared to non-fluorinated counterparts. The was attributable nanoscale fluorous effect in Pdots that maintained molecular planarity and minimized structure distortion between excited state ground state, thus reducing nonradiative relaxations. By...
Mesoporous silica coated upconverting nanoparticles are loaded with the anticancer drug doxorubicin and grafted ruthenium complexes as photoactive molecular valves. Drug release was triggered by 974 nm light 0.35 W cm(-2). Such low intensity minimized overheating problems prevented photodamage to biological samples.
Photon upconversion lithography is demonstrated for the patterning of proteins using near-infrared light. Proteins and an upconverting-nanoparticle-decorated substrate are linked via blue-light-cleavable Ru complexes. The irradiated light with a photomask. In exposed areas, upconverting nanoparticles convert into blue light, which induces cleavage complexes release proteins. Photolithography photopatterning technique widely used in industry academia. photolithography, transfers patterns from...
Anion exchange membranes (AEMs) based on 1,2,3-triazolium (TAM) were prepared from commercial poly(2,6-dimethyl phenylene oxide) (PPO) via "click chemistry" and subsequent N-alkylation. Flexible tough with various ion capacities (IECs) obtained by casting the polymers NMP solutions. Although resulting TAM-functionalized PPOs (PPO-TAM) exhibited incomplete in 1 M NaOH or NaHCO3 for 24 h even at elevated temperature, highest hydroxide conductivities of above 20 mS/cm room which is comparable...
Recently, various second near-infrared window (NIR-II, 1000-1700 nm) fluorophores have been synthesized for in vivo imaging with nonradiation, high resolution, and low autofluorescence. However, most of the NIR-II fluorophores, especially inorganic nanoprobes, are mainly retained reticuloendothelial system (RES) such as liver spleen, leading to long-term safety concerns. Herein, a type lanthanide-based excretable nanoparticle, RENPs@Lips, which can be quickly cleared out body after...
Abstract The dysfunction of the circulatory system leads to various pathological processes with high morbidity. Recently, fluorescence imaging in near‐infrared II (NIR‐II) window (1000–1700 nm) has attracted immense attention many biological processes. rapid metabolism and low toxicity some NIR‐II organic small molecules indicate their feasibility for use visualizing system. However, most reported presently encounter such dilemmas as complicated synthetic procedures quantum yields (QY). To...
Abstract Exhaled breath‐based disease diagnosis is an ancient technique, and the application of this technique rapidly developing for quick testing, such as viral infection, asthma, chronic kidney disease, so on. Among diagnostic tools, exhaled test has demonstrated merits being non‐invasive, convenient, quick, comfortable. In review, breath via gaseous part major focus. First, summary state‐of‐art studies based on gas detection described. Second, typical disease‐related their measurements...
The concept that systemically administered nanoparticles are highly accumulated into the liver, spleen and kidney is a central paradigm in field of nanomedicine. Here, we report bone an important organ for retention small polymer using vivo fluorescence imaging second near-infrared (NIR-II) window. We prepared different sized with both visible NIR-II fluorescence. reveals behavior nanoparticle distribution was largely dependent on particle size. Small ∼15 nm diameter showed fast accumulation...
Abstract Recently, much attention has been focused on the development of second near‐infrared window (NIR‐II, 1000–1700 nm) fluorescence imaging because its reduced scattering, minimal absorption, and negligible autofluorescence. NIR‐II bioimaging allows visualization deep anatomical features with an unprecedented degree clarity. In addition to construction a variety new fluorophores, using tail emission greater than 1000 nm for conventional NIR‐I dyes represents promising strategy...
We developed a dual-modality nanoprobe that can serve as negative contrast agent for both MRI and NIR-II imaging of hepatocellular carcinoma.
Tumor recurrence and wound repair are two major challenges following cancer surgical resection that can be addressed through precision nanomedicine. Herein, palladium nanoparticles (Pd NPs) with photothermal photodynamic therapy (PTT/PDT) capacity were successfully synthesized. The Pd NPs loaded chemotherapeutic doxorubicin (DOX) to form hydrogels (Pd/DOX@hydrogel) as a smart anti-tumor platform. composed of clinically approved agarose chitosan, excellent biocompatibility healing ability....
We present an overview on the design of rare earth doped nanomaterials with controlled size, morphology, heterostructure and surface chemistry to create brightly emitting particles monolithic nanostructured optically active polymeric composites for infrared-based applications.
Lanthanide complexes are firstly applied for <italic>in vivo</italic> NIR-II high resolution whole body bioimaging.
ABSTRACT Copper sulfide nanoparticles (CuS NPs) is a promising and efficient photothermal agent, which widely utilized for cancer therapy. Thus, hyperstable CuS NPs with strong absorbance in second near infrared (NIR‐II) biowindow were prepared by solvent thermal method, demonstrated good stability biocompatibility, deeper tissue penetration of NIR‐II light therapy comparison to that first (NIR‐I) biowindow. Subsequently, CuS@Hydrogel was constructed incorporation Ca 2+ ions crosslinked...
Cerebral collateral circulation and blood-brain barrier (BBB) are critically required to maintain the normal brain functions, a fact stressing need for accurate in vivo diagnostic tools that can afford valuable pathophysiological insight into functioning of neurovascular unit space time. Currently, understanding perfusion BBB evolution under both physiological pathological conditions remains sparse, largely owing limitations methods recording diminutive route cerebral blood flow. Here, it is...