A5039358267- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Photoacoustic and Ultrasonic Imaging
- Ecology and Vegetation Dynamics Studies
- Advanced Fluorescence Microscopy Techniques
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Photochromic and Fluorescence Chemistry
- Molecular Sensors and Ion Detection
- Polydiacetylene-based materials and applications
- Plant Ecology and Soil Science
- Photodynamic Therapy Research Studies
- Carbon and Quantum Dots Applications
- Ultrasound and Hyperthermia Applications
- Forest Ecology and Biodiversity Studies
- Covalent Organic Framework Applications
- Agriculture, Soil, Plant Science
- Advanced Biosensing Techniques and Applications
- Forest ecology and management
- Fire effects on ecosystems
- RNA Interference and Gene Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Soil Carbon and Nitrogen Dynamics
Southern University of Science and Technology
2017-2025
Shenzhen University
2024
Hebei GEO University
2008-2023
State Key Laboratory of Food Science and Technology
2022-2023
Nanchang University
2022-2023
Weifang People's Hospital
2022-2023
Donghua University
2022
Harbin Medical University
2020
First Affiliated Hospital of Harbin Medical University
2020
Jilin University
2013-2019
Fluorescence probes in the NIR-IIa region show drastically improved imaging owing to reduced photon scattering and autofluorescence biological tissues. Now, polymer dots (Pdots) are developed with a dual fluorescence enhancement mechanism. First, aggregation induced emission of phenothiazine was used reduce nonradiative decay pathways polymers condensed states. Second, quenching minimized by different levels steric hindrance further boost fluorescence. The resulting Pdots displayed QY ca....
Light has been widely used for cancer therapeutics such as photodynamic therapy (PDT) and photothermal therapy. This paper describes a strategy called enzyme-enhanced phototherapy (EEPT) treatment. We constructed nanoparticle platform by covalent conjugation of glucose oxidase (GOx) to small polymer dots, which could be persistently immobilized into tumor. While the malignant tumors have high uptake, GOx efficiently catalyzes oxidation with simultaneous generation H2O2. Under light...
Two methoxy-substituted tetraphenylethylene (TPE) derivatives, tetra(4-methoxyphenyl)ethylene (TMOE) and tetra(3,4-dimethoxyphenyl)ethylene (TDMOE), were synthesized by McMurry reaction in high yields. The nearly centrosymmetric natural propeller shape of TMOE TDMOE excluded intermolecular effects, such as H or J-aggregation π–π stacking, on their AIE (AIEE) mechanofluorochromic performance. crystal structures TDMOE, theoretical calculations proved that emission colours are determined single...
Optical nanomaterials with intense absorption in near-infrared (NIR) region hold great promise for biomedical applications such as photothermal therapy (PTT) and photoacoustic imaging (PAI). In this work, we report mesoporous carbon nanospheres (Meso-CNs) broadband the UV-Vis-NIR (300-1400 nm) explore their potential a multifunctional platform chemo-photothermal therapy.
The photosensitizers used in photodynamic therapy are mainly based on porphyrin derivatives. However, clinical applications encounter several limitations regarding such as their low absorption coefficients, poor water-solubility, and leaching from delivery carriers. Here, we describe covalent incorporation of conjugated polymer backbone for development efficient polymer-dot photosensitizer. Spectroscopic characterizations revealed that the light-harvesting dominantly transfer excitation...
Photochromic probes with reversible fluorescence have revolutionized the fields of single molecule spectroscopy and super-resolution microscopy, but lack sufficient chemical specificity. In contrast, Raman stimulated scattering (SRS) microscopy provides superb resolution for super-multiplexed imaging, are relatively inert. Here we report vibrational photochromism by engineering alkyne tagged diarylethene to realize photo-switchable SRS imaging. The narrow peak group shifts reversibly upon...
Abstract The ultralow concentration of nucleic acids in complex biological samples requires fluorescence probes with high specificity and sensitivity. Herein, a new kind spherical (SNAs) is developed by using fluorescent π‐conjugated polymers (FCPs) as light‐harvesting antenna to enhance the signal transduction acid detection. Specifically, amphiphilic DNA‐grafted FCPs are synthesized self‐assemble into FCP‐SNA structures. Tuning hydrophobicity graft copolymer can adjust size capability...
Fingerprint imaging and recognition represent the most important approach in personal identification. Here we designed synthesized oxetane-functionalized semiconductor polymer dots (Ox-Pdots) for covalent patterning rapid visualization of latent fingerprints. The high fluorescence brightness, large Stokes shift, excellent surface properties Ox-Pdots lead to fingerprint with sensitivity resolution. ridge structures first, second, third levels details were clearly developed within minutes....
Control of stereochemistry plays a key role in medicinal chemistry, material and life science. As prominent AIE luminogen, tetraphenylethene (TPE) derivatives have E/Z isomers which are challenging to separate even by HPLC. Herein, we designed oxetane-substituted TPE (TPE-2OXE) separated pure simple column chromatography with high yields, as confirmed mass spectrometry, IR NMR spectroscopy. The isomerization the two can occur photo- thermo-activation. Importantly, (Z)-TPE-2OXE isomer solid...
The concept that systemically administered nanoparticles are highly accumulated into the liver, spleen and kidney is a central paradigm in field of nanomedicine. Here, we report bone an important organ for retention small polymer using vivo fluorescence imaging second near-infrared (NIR-II) window. We prepared different sized with both visible NIR-II fluorescence. reveals behavior nanoparticle distribution was largely dependent on particle size. Small ∼15 nm diameter showed fast accumulation...
Single-arm extended tetraphenylethylene derivatives exhibit full-color tunable mechanofluorochromism and excitation-dependent emissions.
Multicolor organic electrochromic materials are important for the generation of full-color devices. However, achieving multiple colors using a single-molecule material has proved challenging. In this study, multicolor prototype device is generated by integrating medium engineering/in situ 'electro base'/laminated electrode technologies with simple flying fish-shaped methyl ketone TM1. This (green, blue and magenta) durable high coloration efficiency (350 cm2 C−1), fast switching time (50 ms)...
Abstract Aggregation induced emission (AIE) has attracted considerable interest for the development of fluorescence probes. However, controlling bioconjugation and cellular labeling AIE dots is a challenging problem. Here, this study reports general approach preparing small bioconjugated specific targets. The strategy based on synthesis oxetane‐substituted AIEgens to generate compact ultrastable via photo‐crosslinking. A amount polymer enriched with oxetane groups cocondensed most...
Abstract Semiconducting polymers are attractive optical materials in optoelectronic devices and biomedical applications because of their superior properties remarkable versatility. Optical imaging the second near‐infrared window (NIR‐II) has become increasingly popular owing to merits large penetration depth high signal noise ratio, leading a great deal interest exploration development probes NIR‐II region. In this review, recent advances semiconducting polymer nanoparticles (SPNs) region...
Fluorescence imaging in the second near-infrared (NIR-II) window has attracted considerable interest investigations of vascular structure and angiogenesis, providing valuable information for precise diagnosis early stage diseases. However, it remains challenging to image small blood vessels deep tissues because strong photon scattering low fluorescence brightness fluorophores. Here, we describe our combined efforts both fluorescent probe design algorithm development high-contrast turbid such...
Abstract We describe small heterojunction polymer dots (Pdots) with deep‐red light catalyzed H 2 generation for diabetic skin wound healing. The Pdots donor/acceptor heterojunctions showed remarkably enhanced photocatalytic activity as compared to the donor or acceptor nanoparticles alone. encapsulate and ascorbic acid into liposomes form Lipo‐Pdots nanoreactors, which selectively scavenge ⋅OH radicals in live cells tissues under 650 nm illumination. antioxidant capacity of is ~10 times...
A new multi-responsive tetraphenylethene functionalized oxazoline molecular switch (TPE-OX) was synthesized, which not only preserves isomerization and AIE properties, but also demonstrates synergistic effects, showing tunable multi-emission both in solution solid states.
Abstract Fluorescence probes in the NIR‐IIa region show drastically improved imaging owing to reduced photon scattering and autofluorescence biological tissues. Now, polymer dots (Pdots) are developed with a dual fluorescence enhancement mechanism. First, aggregation induced emission of phenothiazine was used reduce nonradiative decay pathways polymers condensed states. Second, quenching minimized by different levels steric hindrance further boost fluorescence. The resulting Pdots displayed...