A5038617650- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Lanthanide and Transition Metal Complexes
- Molecular Sensors and Ion Detection
- Metal-Catalyzed Oxygenation Mechanisms
- Nanoplatforms for cancer theranostics
- Crystallography and molecular interactions
- Luminescence and Fluorescent Materials
- Porphyrin and Phthalocyanine Chemistry
- Sulfur Compounds in Biology
- Metalloenzymes and iron-sulfur proteins
- Nitric Oxide and Endothelin Effects
- Enzyme Catalysis and Immobilization
- Metal complexes synthesis and properties
- Radioactive element chemistry and processing
- Photochemistry and Electron Transfer Studies
- Biochemical and Molecular Research
- Biofuel production and bioconversion
- Synthesis and Properties of Aromatic Compounds
- Microbial Metabolic Engineering and Bioproduction
- Porphyrin Metabolism and Disorders
- Electrocatalysts for Energy Conversion
- Trace Elements in Health
- Luminescence Properties of Advanced Materials
- Magnetism in coordination complexes
The University of Texas at Austin
2023-2024
University of Illinois Urbana-Champaign
2021-2023
Beijing National Laboratory for Molecular Sciences
2016-2020
Peking University
2016-2020
State Key Laboratory of Rare Earth Materials Chemistry and Application
2016-2019
We report three synthetic methods to prepare biocompatible Yb<sup>3+</sup>complexes, which displayed high NIR luminescence with quantum yields up 13% in aqueous media. This renders β-fluorinated Yb<sup>3+</sup>porphyrinoids a new class of probes for living cell imaging including time-resolved fluorescence lifetime imaging.
Time-resolved fluorescence lifetime imaging (FLIM) in the near-infrared region of 900-1700 nm not only allows a deep tissue penetration depth but also offers unique benefit quantitative visualization molecular events vivo and is independent local luminescence intensity fluorophore concentration. Herein, we report design wide-range pH sensitive probe based on Yb3+ porphyrinate. The shows increasing NIR emission with pK values ca. 6.6 from 9.0 5.0 displays an elongated 135 to 170 μs at lower...
Diagnostics and therapeutics are generally separate entities in medicine. Theranostics, agents that provide for both modalities, being developed. However, they often require complex syntheses so as to incorporate within one molecular structure diagnostic therapeutic elements. Moreover, their use is complicated by the disparate dosage requirements diagnosis therapy. Herein, we report closely related porphyrinoid regioisomers produced from same 1,3-dipolar cycloaddition reaction give rise...
The design of near-infrared (NIR) emissive lanthanide (Ln) complexes sensitive to external stimulus is fundamentally important for the practical application Ln materials. Because NIR emission from extremely X-H (X = C, N and O) bond vibration, we herein report harness secondary coordination sphere luminescent sensors. Toward this goal, designed synthesized two isomeric [(η5-C5H5)Co{(D3CO)2P O}3]-Yb(III)-7,8,12,13,17,18-hexafluoro-5,10,15,20-tetrakis(pentafluorophenyl)porpholactol emitters,...
Lanthanide complexes are firstly applied for <italic>in vivo</italic> NIR-II high resolution whole body bioimaging.
"Configurational isomerism" is an important approach found in naturally occurring chlorophylls to modulate light harvesting function without significant structural changes; however, this feature has been seldom applied design of antenna ligands for lanthanide (Ln) sensitization. In work, we introduced a bioinspired by orientation β-dilactone moieties on porphyrinates, namely cis-/trans-porphodilactones, the energy transfer process from lowest triplet excited state ligand (T1) emitting level...
Maximizing the regioisomeric effect of β-substituents on photophysical properties porphyrinoids through disruption TT-conjugation and reducing aromaticity.
The “Histidine-brace” (His-brace) copper-binding site, composed of Cu(His) 2 with a backbone amine, is found in metalloproteins diverse functions. A primary example lytic polysaccharide monooxygenase (LPMO), class enzymes that catalyze the oxidative depolymerization polysaccharides, providing not only an energy source for native microorganisms but also route to more effective industrial biomass conversion. Despite its importance, how Cu His-brace site performs this unique and challenging...
In order to investigate the effects of secondary coordination sphere in fine-tuning redox potentials (E°') type 1 blue copper (T1Cu) cupredoxins, we have introduced M13F, M44F, and G116F mutations both individually combination T1Cu center azurin (Az) from Pseudomonas aeruginosa. These variants were found differentially influence E°' T1Cu, with M13F Az decreasing E°', M44F increasing showing a negligible effect. addition, combining increases by 26 mV relative WT-Az, which is very close...
Synthesis of two trans-dihydroxy platinum(IV) porphyrins (TPP, tetraphenylporphyrin and F[Formula: see text]TPP, tetrakispentafluorophenylporphyrin) by dimethyl dioxirane (DMD) oxidation their Pt[Formula: text] porphyrin precursors have been described. The state Pt cation in such complexes was assessed X-ray photoelectron spectroscopy shown to be [Formula: text]4. More importantly, proton found promote the formation stabilization porphyrins, as revealed UV-vis spectroscopic results single...