A5085810240- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Nanoplatforms for cancer theranostics
- Lanthanide and Transition Metal Complexes
- Porphyrin and Phthalocyanine Chemistry
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Endoplasmic Reticulum Stress and Disease
- Biochemical and Molecular Research
- Advanced Nanomaterials in Catalysis
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Radioactive element chemistry and processing
- Ammonia Synthesis and Nitrogen Reduction
- RNA Interference and Gene Delivery
- Metal complexes synthesis and properties
- Electromagnetic Fields and Biological Effects
- Photoreceptor and optogenetics research
- Fluorine in Organic Chemistry
- CO2 Reduction Techniques and Catalysts
- Advanced Photocatalysis Techniques
Beijing National Laboratory for Molecular Sciences
2014-2024
Peking University
2014-2024
State Key Laboratory of Rare Earth Materials Chemistry and Application
2014-2024
Earth-abundant metal-based theranostics, agents that integrate diagnostic and therapeutic functions within the same molecule, may hold key to development of low-cost personalized medicines. Here, we report a set O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic organonickel(II) complexes, Ni-1–4, containing strong σ-donating M–C bonds. Complexes Ni-1–4 are characterized by square-planar coordination geometry as inferred from structural studies Ni-1. They photothermal therapy,...
Abstract Photodynamic therapy (PDT) is a non‐invasive treatment modality against range of cancers and nonmalignant diseases, however one must be aware the risk causing phototoxic reactions after treatment. We herein report bioinspired design next‐generation photosensitizers (PSs) that not only effectively produce ROS but undergo fast metabolism to overcome undesirable side effects. constructed series β‐pyrrolic ring‐opening seco ‐chlorins, termed beidaphyrin ( BP ), beidapholactone BPL their...
The gallium ion (Ga3+ ) has long been believed to disrupt ferric homeostasis in the body by competing with iron cofactors metalloproteins, ultimately leading cell death. This study revealed that through an indirect pathway, can trigger ferroptosis, a type of non-apoptotic death regulated iron. is exemplified complex salen ligand (Ga-1); we found Ga-1 acts as effective anion transporter affect pH gradient and change membrane permeability, mitochondrial dysfunction release ferrous from...
Diagnostics and therapeutics are generally separate entities in medicine. Theranostics, agents that provide for both modalities, being developed. However, they often require complex syntheses so as to incorporate within one molecular structure diagnostic therapeutic elements. Moreover, their use is complicated by the disparate dosage requirements diagnosis therapy. Herein, we report closely related porphyrinoid regioisomers produced from same 1,3-dipolar cycloaddition reaction give rise...
Abstract Construction of Gd III photosensitizers is important for designing theranostic agents owing to the unique properties arising from seven unpaired f electrons 3+ ion. Combining these with advantages porpholactones tunable NIR absorption, we herein report synthesis complexes Gd‐1 – 4 ( 1 , porphyrin; 2 porpholactone; 3 and cis ‐ trans ‐porphodilactone, respectively) investigated their function as singlet oxygen O ) photosensitizers. These displayed quantum yields Φ Δ s) 0.64–0.99 order...
We report here porphodilactol derivatives and their corresponding metal complexes as “all-in-one” phototheranostics by controlling the relationship between intersystem crossing (ISC) photothermal conversion efficiency following photoexcitation.
Gallium(III)-based drugs have gained momentum in cancer therapy due to their iron-dependent anticancer activity. Judicious choice of ligands is critical for improved oral bioavailability, antitumor efficacy, and distinct mechanisms from simple GaIII salts. We describe complexes with planar tetradentate salen [salen=2,3-bis[(4-dialkylamino-2-hydroxybenzylidene)amino]but-2-enedinitrile)] labile axial solvent ligands, which display tumor growth inhibition vitro vivo comparable cisplatin....
Although magnetism undoubtedly influences life on Earth, the science behind biological magnetic sensing is largely a mystery, and it has proved challenging, especially in sciences, to harness interactions of fields (MFs) with matter achieve specific ends. Using well-established radical pair (RP) mechanism, we here demonstrate bottom-up strategy for exploitation MF effects living cells by translating knowledge from studies RP reactions performed
Abstract The conversion of CO 2 into fuels or commodity chemicals by electrochemical photochemical reduction is a promising strategy to relieve the ongoing energy crisis and increasing environmental pollution. Inspired naturally occurring bimetalloenzymes, we have designed hetero–bimetallic catalysts ( FeM ) that involve linking an iron tetraphenylporphyrin FeP with tripyridylamine (TPA) moiety, which provides distal chelating site for Cu 2+ Zn . We found introduction greatly enhances its...
We described the first application of lanthanide porphyrinoids, exemplified by lutetium, as efficient photosensitizers in photon upconversion based on TTA.
NIR fluorescent palladium(<sc>ii</sc>) complexes were firstly achieved by the formation of M–C bonds and reducing π-conjugation macrocyclic ligands. The capability <italic>in vitro</italic> vivo</italic> bioimaging has been demonstrated.
Synthesis of two bimodal imaging agents consist a hydrophobic zinc(II) tetrapentafluorophenylporpholactol core and β-substituted hydrophilic Gd ( III ) DO3A (ZnLGd 539 or DOTA 595 like moiety has been described (DO3A = 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). Through β-conjugation approach, the absorption at deep red region increases compared to traditional conjugation methods meso-position. More importantly, these new...
We describe the synthesis of β-fluorinated porpholactones by oxidation fluorinated CC bond pyrrolic subunit in porphyrin using “RuCl<sub>3</sub> + Oxone®” protocol.
The hypoxic microenvironment is considered the preponderant initiator to trigger a cascade of progression and metastasis tumors, also being major obstacle for oxygen consumption therapeutics, including photodynamic therapy (PDT). In this work, we report programmable strategy at molecular level modulate reciprocal interplay between tumor hypoxia, angiogenesis, PDT outcomes by reinforcing synergistic action H2O2 scavenger, O2 generator photosensitizer. modular combination catalase biomimetic...
Abstract The gallium ion (Ga 3+ ) has long been believed to disrupt ferric homeostasis in the body by competing with iron cofactors metalloproteins, ultimately leading cell death. This study revealed that through an indirect pathway, can trigger ferroptosis, a type of non‐apoptotic death regulated iron. is exemplified complex salen ligand ( Ga‐1 ); we found acts as effective anion transporter affect pH gradient and change membrane permeability, mitochondrial dysfunction release ferrous from...
Molecular phototheranostics as an emerging field of modern precision medicine has recently attracted increasing research attention owing to non-invasiveness, high precision, and controllable nature light. In this work, we reported promising gadolinium (Gd3+ ) porphyrinoids phototheranostic agents for magnetic resonance imaging (MRI) photodynamic therapy (PDT). The synthesized Gd-1-4-Glu featured with meso-glycosylation β-lactonization endow good biocompatibility improved photophysical...
Abstract Photodynamic therapy (PDT) is a non‐invasive treatment modality against range of cancers and nonmalignant diseases, however one must be aware the risk causing phototoxic reactions after treatment. We herein report bioinspired design next‐generation photosensitizers (PSs) that not only effectively produce ROS but undergo fast metabolism to overcome undesirable side effects. constructed series β‐pyrrolic ring‐opening seco ‐chlorins, termed beidaphyrin ( BP ), beidapholactone BPL their...
Cell senescence is defined as irreversible cell cycle arrest, which can be triggered by telomere shortening or various types of genotoxic stress. Induction emerging a new strategy for the treatment cancer, especially when sequentially combined with second senolytic drug capable killing resulting senescent cells, however severely suffering from undesired off-target side effects drugs. Here, we prepare bimetalic platinum-aluminum salen complex (Alumiplatin) cancer therapy-a combination...
Abstract Gallium(III)‐based drugs have gained momentum in cancer therapy due to their iron‐dependent anticancer activity. Judicious choice of ligands is critical for improved oral bioavailability, antitumor efficacy, and distinct mechanisms from simple Ga III salts. We describe complexes with planar tetradentate salen [salen=2,3‐bis[(4‐dialkylamino‐2‐hydroxybenzylidene)amino]but‐2‐enedinitrile)] labile axial solvent ligands, which display tumor growth inhibition vitro vivo comparable...