A5005542954- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- X-ray Diffraction in Crystallography
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- Lanthanide and Transition Metal Complexes
- Porphyrin and Phthalocyanine Chemistry
- Metal complexes synthesis and properties
- Photodynamic Therapy Research Studies
- Radiopharmaceutical Chemistry and Applications
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Adrenal and Paraganglionic Tumors
- Radioactive element chemistry and processing
- Hormonal Regulation and Hypertension
- Peptidase Inhibition and Analysis
- Endoplasmic Reticulum Stress and Disease
- DNA and Nucleic Acid Chemistry
- Luminescence Properties of Advanced Materials
- Mitochondrial Function and Pathology
- Geochemistry and Elemental Analysis
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
Peking University
2020-2025
Beijing National Laboratory for Molecular Sciences
2020-2025
State Key Laboratory of Rare Earth Materials Chemistry and Application
2020-2024
Central Hospital of Wuhan
2022-2024
Huazhong University of Science and Technology
2022-2024
Hubei University of Chinese Medicine
2019-2022
Guangxi Medical University
2022
Exosomal microRNAs are essential in intercellular communications and disease progression, yet it remains challenging to quantify the expression level due their small size low abundance blood. Here, we report a "sandwich" electrochemical exosomal microRNA sensor (SEEmiR) detect target with high sensitivity specificity. In SEEmiR, neutrally charged peptide nucleic acid (PNA) enables kinetically favorable hybridization relative negatively DNA, particularly short sequence (10 nt). More...
Abstract Photodynamic therapy (PDT) is a non‐invasive treatment modality against range of cancers and nonmalignant diseases, however one must be aware the risk causing phototoxic reactions after treatment. We herein report bioinspired design next‐generation photosensitizers (PSs) that not only effectively produce ROS but undergo fast metabolism to overcome undesirable side effects. constructed series β‐pyrrolic ring‐opening seco ‐chlorins, termed beidaphyrin ( BP ), beidapholactone BPL their...
The gallium ion (Ga3+ ) has long been believed to disrupt ferric homeostasis in the body by competing with iron cofactors metalloproteins, ultimately leading cell death. This study revealed that through an indirect pathway, can trigger ferroptosis, a type of non-apoptotic death regulated iron. is exemplified complex salen ligand (Ga-1); we found Ga-1 acts as effective anion transporter affect pH gradient and change membrane permeability, mitochondrial dysfunction release ferrous from...
Protein disulfide isomerase (PDI), a family of thiol‐disulfide oxidoreductases, is one the most abundant soluble proteins in endoplasmic reticulum (ER) and responsible for protein folding. Increasing evidence suggests that PDI overexpressed multiple types cancer, positioning it as promising target tumor therapy. We have designed synthesized series gallium complex‐based proteolysis targeting chimeras (PROTACs), which exhibited effective degradation vitro. After analyzing relationship between...
Exosome-associated liquid biopsies are hampered by challenges in the exosomal quantification and phenotyping. Here, we present a bioinspired exosome-activated DNA molecular machine (ExoADM) with multivalent cyclic amplification that enables highly sensitive detection phenotyping of circulating exosomes. ExoADM harbors two (an exposed hidden) toehold domains actuate sequential branch migration recycling response to surface markers. Importantly, this self-powered achieves high sensitivity (33...
Abstract Gallium, the group 13 metal, has been found to be potentially useful in fighting against cancers since last century. The trivalent Ga(III) shares most chemical properties except redox activity with Fe(III), so that it acts as a competitive inhibitor of Fe(III) vitro and vivo, which contributes its antineoplastic activity. As an mimic, can uptaken into cells through transferrin stored ferritin. Furthermore, disrupts Fe‐dependent processes, for example, by inhibiting ribonucleotide...
MicroRNA (MiRNA)-based noninvasive diagnostics are hampered by the challenge in quantification of circulating miRNAs using a general strategy. Here, we present base-stacking effect-mediated ultrasensitive electrochemical miRNA sensor (BSee-miR) with universal sandwich configuration. In BSee-miR, short DNA probe (10 nucleotides) self-assembled on gold electrode surface could effectively capture target synergizing another sequence based coaxial base-stacking, which rivals fully complementary...
Abstract The gallium ion (Ga 3+ ) has long been believed to disrupt ferric homeostasis in the body by competing with iron cofactors metalloproteins, ultimately leading cell death. This study revealed that through an indirect pathway, can trigger ferroptosis, a type of non‐apoptotic death regulated iron. is exemplified complex salen ligand ( Ga‐1 ); we found acts as effective anion transporter affect pH gradient and change membrane permeability, mitochondrial dysfunction release ferrous from...
Abstract Photodynamic therapy (PDT) is a non‐invasive treatment modality against range of cancers and nonmalignant diseases, however one must be aware the risk causing phototoxic reactions after treatment. We herein report bioinspired design next‐generation photosensitizers (PSs) that not only effectively produce ROS but undergo fast metabolism to overcome undesirable side effects. constructed series β‐pyrrolic ring‐opening seco ‐chlorins, termed beidaphyrin ( BP ), beidapholactone BPL their...
Cell senescence is defined as irreversible cell cycle arrest, which can be triggered by telomere shortening or various types of genotoxic stress. Induction emerging a new strategy for the treatment cancer, especially when sequentially combined with second senolytic drug capable killing resulting senescent cells, however severely suffering from undesired off-target side effects drugs. Here, we prepare bimetalic platinum-aluminum salen complex (Alumiplatin) cancer therapy-a combination...