A5103157065- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- RNA Interference and Gene Delivery
- Metal and Thin Film Mechanics
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Analytical Chemistry and Sensors
- RNA modifications and cancer
- Nanopore and Nanochannel Transport Studies
- Extracellular vesicles in disease
- Advanced materials and composites
- Advanced ceramic materials synthesis
- Neuroscience and Neural Engineering
- Conducting polymers and applications
- MicroRNA in disease regulation
- Endometrial and Cervical Cancer Treatments
- Biosensors and Analytical Detection
- DNA and Nucleic Acid Chemistry
- Oxidative Organic Chemistry Reactions
- Advanced Sensor and Energy Harvesting Materials
- Colorectal Cancer Treatments and Studies
- Sarcoma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
Chinese Academy of Sciences
2025
Institute of Urban Environment
2025
Nantong University
2025
University of South China
2024
Hubei University of Chinese Medicine
2015-2024
Fujian Provincial Cancer Hospital
2014-2024
Fujian Medical University
2023-2024
Chongqing University
2024
People's Liberation Army No. 150 Hospital
2024
Chinese People's Liberation Army
2024
Propagation rate coefficients, kp, of N-vinyl pyrrolidone (NVP) radical polymerization in aqueous solution have been measured via the pulsed-laser - size exclusion chromatography method (PLP−SEC) over an extended concentration range from 1.8 to 100 wt % NVP at temperatures between 2 and 60 °C. The SEC analyses carried out by a modified procedure using dimethyl acetamide as eluent. An about 20-fold increase kp is observed passing bulk reaction dilute solution. As with nonionized methacrylic...
Here, we demonstrate a phosphorodiamidate morpholino oligos (PMO)-functionalized nanochannel biosensor for label-free detection of microRNAs (miRNAs) with ultrasensitivity and high sequence specificity. PMO, as capture probe, was covalently anchored on the surface. Because neutral character sequence-specific affinity hybridization efficiency between PMO miRNAs enhanced, thus largely decreasing background signals highly improving specificity sensitivity. The realized through observing change...
The path toward field-effect transistor (FET) application from laboratory to clinic has delivered a compelling push in the biomedical domain, yet ultrasensitive and timely pathogen identification without PCR remains long-lasting challenge. Herein, we create generic check station termed "CRISPR-FET", first incorporating CRISPR/Cas13a system within FET modality, for accelerated unamplified detection of viral RNA. Unlike conventional FETs bearing target-specific receptors, this sensor holds...
A concise and efficient approach to the syntheses of coumestan analogues has been developed. The underpinning strategy involves a FeCl3-mediated direct intramolecular oxidative annellation 4-hydroxy-3-phenyl-2H-chromen-2-one derivatives. Utilizing this synthetic protocol, variety derivatives were conveniently obtained from readily available reagents.
DNA detection based on peptide nucleic acid (PNA)–DNA hybridization is emerging as an important method in the area of microarrays and biosensors because PNA shows remarkable properties. In this work, we provide a novel, simple, sensitive, selective strategy PNA–graphene oxide (GO) assembled biosensor for fluorescence turn-on DNA, which new nanomaterial GO was used scaffold quencher fluorophore. The PNA–GO capable distinguishing sequence specificity including complementary, one-base...
MoS<sub>2</sub>/Pt nanocomposites functionalized acupuncture needle for real-time monitoring of H<sub>2</sub>O<sub>2</sub>release from living cells.
Abstract This study reports an acupuncture needle modified with iron-porphyrin functionalized graphene composite (FGPC) for real-time monitoring of nitric oxide (NO) release in acupoints rats. A gold film was first deposited to the surface enhance conductivity. The FGPC prepared via hydrothermal synthesis, and subsequently applied tip by electrochemical deposition method. enabled a specific sensitive detection NO based on favorably catalytic properties excellent conductivity graphene....
PM2.5 pollution poses significant health risks in urban areas, yet the specific cardiovascular impacts of its hazardous components, especially transition metals, remain insufficiently understood. This study evaluated associations components on acute myocardial infarction (AMI) and aortic dissections (AAD) emergency hospitalizations (n = 9985) using a time-stratified case-crossover between 2017 2023 Xiamen, China. We collected comprehensive data daily air pollutants, (water-soluble ions,...
To fabricate recyclable catalytic materials with high activity, Se4+@TiO2 photocatalytic were synthesized by the sol–gel method. By introducing free radicals on surface of polyester (PET) fabrics through plasma technology, Se4+@TiO2/PET composite activity prepared. The morphology, crystal structure, chemical composition, and performance characterized scanning electron microscopy (SEM), X-ray diffraction (XRD), photoelectron spectroscopy (XPS), ultraviolet–visible absorption (UV–Vis),...
Abstract We report a unique nanosensing platform by combining modern nanotechnology with traditional acupuncture needle to prepare graphene-modified (G-AN) and using it for sensitive detection of neurotransmitters via electrochemistry. An electrochemical deposition method was employed deposit Au nanoparticles (AuNPs) on the tip surface needle, while other part coated insulation paste. Subsequently, G-AN obtained cyclic voltammetry reduction graphene oxide solution AuNPs. To investigate...
Abstract Acupuncture treatment is amazing but controversial. Up to now, the mechanism of treating diseases by acupuncture and moxibustion still unclear, especially occurrence molecular events in local acupoints. Herein, we report an extremely stable microsensor modifying carbon nanotube (CNT) tip surface needle applying this CNT-modified for real time monitoring serotonin (5-HT) vivo . To stabilize CNT modification on surface, poly(3,4-ethylenedioxythiophene)(PEDOT) was employed as glue...
The mechanism of estrogen receptor alpha (ERα)-positive breast cancer-associated bone metastasis is poorly understood. In this article, we report that nuclear p21-activated kinase 4 (nPAK4) a novel repressor ERα-mediated transactivation in 17β-estradiol (E2)-dependent manner and promotes PAK4–ERα axis-mediated by targeting leukemia inhibitory factor (LIFR) ERα-positive cancer. An evaluation clinical cancer samples revealed nPAK4 linked to ERα expression appears be associated with poor...
Glutamate, one of the most important central excitatory neurotransmitters, plays crucial roles in nerve signal transduction and is implicated several neurological disorders. However, no effective means has been developed for specific detection glutamate released from primary cultured neurons. Here we present a reduced graphene oxide (RGO)-based field effect transistor (FET) biosensor functionalized with synthesized receptor real-time monitoring release rat hippocampus Metabotropic receptors...
Abstract Chemical communication via neurotransmitters is central to brain functions. Nevertheless, in vivo real‐time monitoring of released the brain, especially electrochemically inactive molecules, remains a great challenge. In this work, novel needle field‐effect transistor (FET) microsensor based on an acupuncture proposed, which demonstrated be capable dopamine molecules as well neuropeptide Y vivo. The FET microstructure fabricated by successively wrapping insulating layer and gold top...