A5101937141- Angiogenesis and VEGF in Cancer
- Ovarian function and disorders
- Cell Adhesion Molecules Research
- Reproductive Biology and Fertility
- Sarcoma Diagnosis and Treatment
- Chemokine receptors and signaling
- Prion Diseases and Protein Misfolding
- Retinoids in leukemia and cellular processes
- MicroRNA in disease regulation
- Retinopathy of Prematurity Studies
- Retinal Diseases and Treatments
- RNA modifications and cancer
- Management of metastatic bone disease
- RNA Interference and Gene Delivery
- Medical Imaging Techniques and Applications
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Kruppel-like factors research
- Cancer-related gene regulation
- Medical Imaging and Analysis
- Acute Myeloid Leukemia Research
- Cancer Research and Treatments
- Neutropenia and Cancer Infections
- Ocular and Laser Science Research
Exelixis (United States)
2025
Shanghai Jiao Tong University
2009-2022
Shanghai Sixth People's Hospital
2019-2020
Affiliated Hospital of Nantong University
2020
Nantong University
2020
University of Electronic Science and Technology of China
2017
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2017
Harbin Medical University
2012-2014
First Affiliated Hospital of Harbin Medical University
2012-2014
Shanghai First People's Hospital
2008-2014
Tumor-targeting drug delivery systems are being the ideal carrier for systemic administration of antiproliferative drugs. RGD peptide (arginine-glycine-aspartic acid) modified liposomes containing paclitaxel (RGD-SSL-PTX). The arginine-glycine-aspartic acid tripeptide (RGD) sterically stabilized (SSL) (PTX) (RGD-SSL-PTX), which could increase targeting to tumor by binding with integrin receptors overexpressed on cells. encapsulation efficiency was more than 90% and mean particle size 120 nm...
Many angiogenesis inhibitors are derived from large plasma proteins. Previous studies showed that the Kringle5-like domain (termed KV) in human apolipoprotein (a) is a potential antiangiogenic factor. However, its active region and underling molecular mechanism remain elusive. Here, we identified an 11-amino acid peptide (named KV11) as key for function of KV (a). We demonstrate KV11 inhibits vitro by suppressing umbilical vein endothelial cell migration microtubule formation. chicken...
The prognosis of acute promyelocytic leukemia (APL) in the elderly is poorer than that younger patients after treatment with all-trans retinoic acid plus chemotherapy, which current standard therapy for APL. A significantly higher mortality during consolidation was found, mainly due to deaths from sepsis following chemotherapy-induced myelosuppression.A total 33 aged 60 years or older de novo APL were treated single-agent arsenic trioxide (ATO) remission induction and postremission therapy....
Purpose.: Hyperglycemia-induced mitochondrial reactive oxygen species (ROS) production plays an important role in the development of complications diabetes such as retinopathy. However, whether pigment epithelium–derived factor (PEDF) can decrease ROS remains uncertain. The aim this study was to clarify PEDF mitochondria-derived generation and subsequently downregulate vascular endothelial growth (VEGF) expression; authors also investigated involvement Janus kinase 2/signal transducer...
Abstract Background: Tissue factor (TF) is a transmembrane glycoprotein that plays an important role in the extrinsic coagulation cascade. TF aberrantly expressed various cancers, and its expression generally associated with poor disease outcomes. XB371 anti-TF antibody-drug conjugate, developed using SMARTag® platform, designed to deliver cytotoxic payload TF-expressing tumors while minimizing adverse events related disruption of function, notably bleeding. composed tandem-cleavage...
A keratinolytic alkaline proteae (NAPase) from Nocardiopsis sp. TOA-1 degraded a scrapie prion without any chemical or physical treatment. Optimal temperature and pH were 60 °C above 10.0. The was completely within 3 min under optimal conditions.
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine diseases of fertile women and a major cause infertility. The regulatory effects DNA methylation on gene transcription downstream lipid metabolism have not been explored in PCOS. In this study, MBD‐seq RNA‐seq were performed ovarian granulosa cells PCOS patients controls, specific PCR quantitative polymerase chain reaction used to validate results. Then lipidomic profiling was conducted serum controls using UPLC‐MS. We...
Polycystic ovary syndrome (PCOS) is a prevalent heterogeneous endocrine and metabolic disorder in women of reproductive age. Epigenetic mechanisms contribute to the development PCOS. Nevertheless, role DNA methylation PCOS remains unclear. To investigate molecular underlying hyperandrogenic phenotype PCOS, dihydrotestosterone (DHT)-induced prenatally androgenized (PNA) mice were used mimic this phenotype. Ovarian samples from PNA control subjected methyl-CpG-binding domain (MBD)-seq RNA-seq,...
Background: Polycystic ovary syndrome (PCOS) is a common multifactorial metabolic and endocrine disorder in women of reproductive age. Increasingly, evidence indicates that the microRNA (miRNA)-mRNA axis contributes to development PCOS.
Purpose.: To evaluate the effect of KV11, a novel 11-mer peptide from human apolipoprotein(a), against retinal neovascularization and to study its penetration possible toxicity retina. Methods.: Wound-healing, modified Boyden chamber, MTS assays were used KV11 on migration proliferation bovine capillary endothelial cells (BRCECs) induced by vascular growth factor (VEGF) in vitro. The antiangiogenic was also studied with mouse model oxygen-induced retinopathy. Then, FITC-labeled injected into...
Wnt family member 5a (Wnt5a) is a noncanonical of the that highly expressed in atherosclerosis. Studies have shown Wnt5a/receptor tyrosine kinase‑like orphan receptors 2 (Ror2) signaling can participate formation foam cells; however, role Ror2 vascular endothelial cells during atherosclerotic injury unknown. Therefore, present study aimed to investigate tumor necrosis factor (TNF)‑α‑induced cell and whether it could be regulated by Wnt5a. Human umbilical vein were transfected with short...
Aberration in microRNA (miRNA) expression or DNA methylation is a causal factor for polycystic ovarian syndrome (PCOS), common endocrine disorder and leading cause of infertility. However, the epigenetic interactions between miRNA remain unexplored PCOS. In this study, we conducted an integrated analysis RNA-seq, miRNA-seq MBD-seq on granulosa cells PCOS control groups to reveal involved pathogenesis Firstly, identified 830 genes 30 miRNAs that were expressed differently PCOS, seven found...
Purpose: We evaluated the imaging and clinical features for discriminating possibility of metastasis among FDG-avid bone lesions in 18F-FDG PET/CT patients who have received biopsy.Methods: The retrospective study included underwent both 18 F-FDG biopsy lesions.Bone maximum standardized uptake value (SUVmax), CT findings, alongside with common were analyzed.Results: From 338 enrolled final study, all them biopsy.Biopsies confirm 256 cases (75.74%) benign tissue 82 (24.26%).Metastasis group...
Purpose: The aim of this study was to evaluate the antiangiogenic activity AU6, a novel 6-amino acid peptide derived from Kringle V human apolipoprotein (a). Methods: RF/6A rhesus macaque choroid endothelial cells were used for in vitro studies. MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt] assays and modified Boyden chamber Matrigel inhibitory effect AU6 on vascular growth factor (VEGF)-stimulated cell functions, including...
Lung cancer is one of the most commonly diagnosed worldwide. As liquid biopsy analytes, alternations in cell-free DNA (cfDNA) methylation could function as promising biomarkers for lung detection. In this study, differential analysis was performed to identify candidate markers, and lasso regression with 10-fold cross-validation (CV) used establish diagnostic marker panel. The performance binary classifier evaluated using receiver operating characteristic (ROC) curve precision-recall (PR)...