The purpose of this study was to explore the potential molecular mechanisms excess homocysteine in relation autophagic activity ovarian tissue polycystic syndrome (PCOS) with hyperandrogenism.A PCOS model constructed using ICR mice. ELISA used detect Hcy levels serum and tissues model. expression level key enzymes (Methionine synthase Betaine-homocysteine methyltransferase, MTR BHMT) metabolism autophagy-related proteins were detected mouse granulosa cells (mGCs) that treated homocysteine,...

With the increasing diversification of customers' demand and purchasing behaviors, more manufacturers have focused their attention on warranty service contracts design. The maintenance duration sold product, which plays an important role in normal production operation process user, is frequently taken into consideration contracts. In this study, we design different with various combinations availability requirements. manufacturer commits to compensate for each overdue repair or failing...

Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine diseases of fertile women and a major cause infertility. The regulatory effects DNA methylation on gene transcription downstream lipid metabolism have not been explored in PCOS. In this study, MBD‐seq RNA‐seq were performed ovarian granulosa cells PCOS patients controls, specific PCR quantitative polymerase chain reaction used to validate results. Then lipidomic profiling was conducted serum controls using UPLC‐MS. We...

Abstract With the continuous development of China’s information technology, “Internet Things plus” era, under background knowledge society, city gradually evolved into an open innovation model, in order to adapt times, smart cities came being. In addition, regional industry is mainly specific area city, distribution economic relations between urban areas reflect. Therefore, this paper expounds concept Plus” and related technical analysis, introduces application new applications, puts forward...

This paper presents a discrete-time multi-bit Delta–Sigma modulator employing successive approximation (SA)-quantizers for bio-signal acquisitions. In the proposed [Formula: see text] modulator, input signal is separately quantized and summation performed in digital domain to avoid power hungry analog adder. Two SA-quantizers are used this modulator. One dedicated quantize other of integrators’ outputs. Dynamic Element Matching (DEM) technique mitigate mismatch among digital-to-analog...

With the development of urbanization, power consumption in cities is increased, and distribution equipment load also more concentrated. However, city grids normally suffer from uneven flow high short-circuit current level. In cases peak periods, some substation transformers may encounter overload conditions while nearby are only lightly loaded. Such a dilemma be solved by use electronics devices based on voltage source converters (VSC) technologies. VSC technologies capable optimizing system...

Heat pumps can enhance the utilization of low-grade thermal energy. Setting heat correctly in a exchanger network reduce consumption cold and hot utilities, achieving energy saving pollution reduction. Therefore, targeting optimal placement is great interest both academia industry. Focusing on vapour compression pump, this work proposes simulation-optimization method to identify energy-optimal networks. Based powerful fluid property database, pump system first modelled Aspen HYSYS V10. Next,...

Quality of coverage is the key to affect quality and index mobile communication, so it very important solve problem coverage. From perspective improving 5G wireless network, this paper studies common weak over problems in analyzes causes, processing ideas analysis methods daily centralized optimization, as guide related network optimization work.

With the intensive outfeed of large-capacity high voltage direct current (HVDC) transmission links, grid pattern, operational paradigm, and stability characteristics sending-end have undergone profound changes. In this paper, an evaluation index system is proposed to evaluate adaptability expansion planning schemes power with multiple HVDC links. The constructed comprehensively takes into account four aspects: economic development, generation mix, strength, as well security stability....

Abstract Based on the rapid development of green finance and panel data 30 provinces in China (excluding Tibet, Taiwan, Hong Kong Macao) from 2007 to 2020, deeply discuss relationship between financial (FD), technological innovation environmental pollution (EP) control is centre this article by using fixed-effect intermediary effect model. The influence FD EP tested building a benchmark regression In addition, model adopted explore how affects through mechanism. conclusions show that China’s...

Current intersection signal control studies mainly consider the passage of motor vehicles, with too little consideration given to pedestrians and non-motorized factors. This has led many unsafe hazards in slow-moving traffic at intersections, such as travel conflicts caused by right-turning vehicles being released same time; red light comes on while vulnerable groups elderly do not finish crossing street, etc. The resulting accident disputes are common. project introduces computer vision...

With the rapid development of world economy, energy security and environmental issues become increasingly prominent. And smart grid turns into common choice for global power industry to respond future challenges grid. Combining with experience research results at home abroad, paper discusses driving force, connotation related technical area from three levels government, enterprise users, a new perspective try answer questions: "Why should we develop grid", "What is "how grid".

Objective To investigate the qpplication of letrozole (LE) combined with human menopausal stimulating gonadotropin (HMG) in ovulation guidance intercourse and related factors HMG dosage. Methods Eighty-three patients met study criteria for selection were selected from March 2014 to February 2015. According whether or not polycystic ovary syndrome (PCOS), they divided into PCOS group (n=43) non (n=40). LE was given two groups. The monitoring indicators (HMG dosage, number dominant...

Taking account of time dependent electricity prices, this paper proposes discrete-time Resource Task Network (RTN) formulations to deal with collaborative scheduling steel production and energy in steelmaking continuous casting (SCC) problem. Due complexity difficulty a large-scale SCC problem, novel two stage method different units is proposed solve the model faster more effective. The numeric experiments show that two-stage very efficient practical realistic iron enterprises.