A5022055126- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Cancer, Hypoxia, and Metabolism
- Aluminum Alloys Composites Properties
- Microstructure and mechanical properties
- Aluminum Alloy Microstructure Properties
- Metabolism, Diabetes, and Cancer
- Force Microscopy Techniques and Applications
- Mechanical and Optical Resonators
- Electrochemical Analysis and Applications
- Gas Sensing Nanomaterials and Sensors
- Integrated Circuits and Semiconductor Failure Analysis
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Optical Imaging Technologies
- Phytoplasmas and Hemiptera pathogens
- Toxin Mechanisms and Immunotoxins
- Advanced biosensing and bioanalysis techniques
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- E-commerce and Technology Innovations
- Photorefractive and Nonlinear Optics
- Electrowetting and Microfluidic Technologies
- Advanced Research in Systems and Signal Processing
- Zebrafish Biomedical Research Applications
- Ginseng Biological Effects and Applications
Shanghai Institute of Materia Medica
2025
Chinese Academy of Sciences
2022-2025
Central South University
2018-2024
Institute of Oceanology
2022-2024
Laoshan Laboratory
2024
University of Chinese Academy of Sciences
2024
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
Guangzhou Electronic Technology (China)
2024
Zhongnan Hospital of Wuhan University
2023
The OmicShare tools platform is a user-friendly online resource for data analysis and visualization, encompassing 161 bioinformatic tools. Users can easily track the progress of projects in real-time through an overview interface. has powerful interactive graphics engine that allows custom-tailored modification charts generated from analyses. visually appealing produced by improve interpretability meet requirements publication. It been acknowledged over 4000 publications available...
An ultrasensitive and highly efficient assay for real-time monitoring of nitric oxide (NO) at single-cell level based on a reduced graphene (RGO) iron-porphyrin-functionalized (FGPCs) field-effect transistor (FET) biosensor is reported. A layer-to-layer assembly RGO FGPCs prefabricated FET sensor surface through π-π stacking interaction allowed superior electrical conductivity caused by RGO, catalytic specificity induced metalloporphyrin, ensuring the specific detection NO. The results...
Abstract Interactions between osteolineage cells and myeloid play important roles in maintaining skeletal homeostasis. Herein, we find that transfer mitochondria to cells. Impairment of the by deleting MIRO1 leads increased cell commitment toward osteoclastic lineage promotes bone resorption. In detail, impaired mitochondrial from alters glutathione metabolism protects ferroptosis, thus promoting osteoclast activities. Furthermore, is involved regulation glucocorticoid-induced osteoporosis,...
Nutrient competition with indigenous microbes or pathogens presents a significant challenge for oral probiotic efficacy. To address this issue, we develop an ameba-inspired food-carrying strategy (AIFS) by prebinding ginger-derived exosome-like nanoparticles (GELNs) onto probiotics as food depots. AIFS enables to efficiently and exclusively consume GELNs in situ, even the presence of competing bacteria. This results up 21 times higher uptake efficiency compared unengineered probiotics,...
Glutamate, one of the most important central excitatory neurotransmitters, plays crucial roles in nerve signal transduction and is implicated several neurological disorders. However, no effective means has been developed for specific detection glutamate released from primary cultured neurons. Here we present a reduced graphene oxide (RGO)-based field effect transistor (FET) biosensor functionalized with synthesized receptor real-time monitoring release rat hippocampus Metabotropic receptors...
MoS₂ nanomaterial has unique properties, including innate affinity with ss-DNA and quenching ability for fluorescence dyes. Here, we present the development of a simple biosensor based on water-soluble nanosheets restriction endonuclease BstUI methylation analysis p16 promoter. The biosensing platform exhibited excellent sensitivity in detecting DNA linear range 100 pM~20 nM detection limit 140 pM. More importantly, our method could distinguish as low 1% difference level. Compared previous...
Background The majority of breast cancers (BCs) expressing estrogen receptor (ER) have shown endocrine resistance. Our previous study demonstrated that ferredoxin reductase (FDXR) promoted mitochondrial function and ER+ tumorigenesis. But the underlying mechanism is not clear. Methods Liquid chromatography (LC) tandem mass spectrometry (MS/MS)-based metabolite profiling was utilized to reveal metabolites regulated by FDXR. RNA microarray determine potential downstream targets Seahorse XF24...
This paper presents the development of an easy-to-handle and disposable clinical diagnostic lab-on-a-chip using fully integrated plastic microfluidic components, which has sampling/identifying capability to make fast reliable measurements metabolic parameters from human whole blood. A smart functional cartridge, incorporates a full on-chip auto-calibration function for in field applications, been developed, then characterized portable analyzer (3 (1/4)''x 5''x 1'') with multi-analyte...
Mitochondria play essential roles in cancer cell adaptation to hypoxia, but the underlying mechanisms remain elusive. Through mitochondrial proteomic profiling, we here find that prolyl hydroxylase EglN1 (PHD2) accumulates on mitochondria under hypoxia. substrate-binding region β2β3 loop is responsible for its translocation and contributes breast tumor growth. Furthermore, identify AMP-activated protein kinase alpha (AMPKα) as an substrate mitochondria. The EglN1-AMPKα interaction their...
In this paper, the on-chip generated mercury microelectrode for heavy metal ion detection has been presented. A droplet (∼150 μm in diameter) is to form a through microfluidics control. The used electrochemically detect ions. sample solutions with different concentration of ions (Pb2+ and Cd2+) have successfully detected on using square wave stripping voltammetry.
This paper presents a fully integrated biosensor array, which includes an oxygen sensor and glucose sensor, for measurement of metabolic parameters in human blood. Partial concentration blood were successfully detected less than one minute using the developed array. Total design is based on low melting point gel-based solid electrolyte that simplified fabrication process. Most are relative to performance calibrated compared optimize design. Such include membrane material, thickness layer,...
Up to now, there has been no report on target molecules detection by a piezoresistive microcantilever aptasensor. In order evaluate the test performance and investigate response dynamic characteristics of aptasensor, novel method for ricin kinetic analysis based aptasensor was proposed, where aptamer immobilised surface biotin-avidin binding system. Results showed that limit 0.04μg L−1 (S/N ≥ 3). A linear relationship between voltage concentration in range 0.2μg L−1-40μg obtained, with...
The brake system of a mine hoist is the key component and last barrier to ensure safe operation in mine. Based on vibration sound signals test system, this paper studied characteristics relationship between both tries propose new fault diagnosis method for system. First, set-up under different braking conditions at disc rotation speeds were collected. Then, filtered reduced by wavelet packet, reconstructed signal eigenvalues extracted. results showed that state normal can be drawn. It shows...
Chemodynamic therapy (CDT) is novel and promising for cancer treatment, however, the potential systematic toxicity of used nanoparticles still a big concern. In this work biocompatible hypocrellin A-Fe(III) (HA-Fe(III) NPs) were synthesized studied. The CDT effect HA-Fe(III) NPs in dark negligible but can be photo-activated upon red light irradiation, which meaningful to realize precise treatment by selective irradiation. Moreover, also generate O2˙-, may converted into H2O2 further enhance...
In this paper, a fully disposable polymer field effect transistor (polymer-FET) for pH measurement has been proposed, fabricated and characterized. A well-defined poly (3-hexylthiophene) (P3HT) is adopted as the semi-conducting material used active layer. The FET on plastic substrate shows I-V characteristics that are comparable to those of Si-based (Si-FET). sensor integrated with microfluidic channel tested sensor, which good linearity in source-drain current versus concentration. This...